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Embolization Materials, Catheters, and Intra-arterial Ports

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Locoregional Tumor Therapy

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Abstract

Catheter-directed embolization therapies for oncologic indications are increasingly gaining importance. Basically, these minimally invasive therapies include locoregional, tumoricidal therapies, pre-, or postoperative adjunctive treatments as well as palliative management options. Although different materials are used depending on the indications, the interventional approach is in most of the cases similar: a diagnostic catheter is placed in the feeding, large artery, and through this guiding catheter, a coaxial “microcatheter” is placed with its tip as close as possible to the target tumoral implants. Once the microcatheter is correctly positioned, chemotherapeutic agents can be carefully injected in order to obtain very high drug concentrations within the tumor and low(er) drug concentrations within the peripheral blood, resulting in high response rates and low(er) systemic toxicity rates. Additionally, occluding microparticles can be injected during or immediately after the chemotherapeutic infusion in order to add an ischemic effect or to create a slower washout phenomenon of the injected cytostatic agents. In case of emergency conditions of bleeding tumors, transcatheter injection of embolics without chemotherapeutic agents may be sufficient to stabilize the patient’s condition.

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Authors and Affiliations

  1. Department of Radiology, University Hospitals Leuven, Leuven, Belgium

    Geert A. Maleux

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  1. Geert A. Maleux
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Correspondence to Geert A. Maleux .

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Editors and Affiliations

  1. Department of Oncology, University Hospital Gasthuisberg Leuven Cancer Institute, Leuven, Belgium

    Eric Van Cutsem

  2. Department of Diagostic Radiology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

    Thomas J. Vogl

  3. Department of Radiology, European Institute of Oncology, Milano, Italy

    Franco Orsi

  4. Department of Medical Oncology, IRCCS Ospedale San Martino IST, Genova, Italy

    Alberto Sobrero

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Maleux, G.A. (2015). Embolization Materials, Catheters, and Intra-arterial Ports. In: Van Cutsem, E., Vogl, T., Orsi, F., Sobrero, A. (eds) Locoregional Tumor Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36572-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-36572-0_3

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