Abstract
The aim of a safe and efficient drug therapy is to direct the agent as near as possible to its target where it generates its maximum pharmacological effect while keeping side effects at a minimum.
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References
Czejka MJ, Georgopoulos A. Pharmakokinetik. In: AKH Consilium der Medizinischen Universität Wien. Universimed Media Verlag, Wien. e-Book; 2006.
Austria Codex. Product information of drugs. 2006. http://www3.apoverlag.at/.
Ritschel W, Kearns G. Handbook of basic pharmacokinetics, including clinical application. 6th ed. Washington, American Pharmacists Association. DC: APHA; 2004.
Collins JM. Pharmacologic rationale for regional drug delivery. J Clin Oncol. 1984;2:498–504.
Czejka MJ, Schüller J, Micksche M. In vitro interaction of interferon-alpha-2b with microspheres particles. Pharmazie. 1992;47:387.
Andersson M, Aronsen KF, Balch C, Domellöf L, Eksborg S, Hafström LO, Howell SB, Kåresen R, Midander J, Teder H. Pharmacokinetics of intra-arterial mitomycin C with or without degradable starch microspheres (DSM) in the treatment of non-resectable liver cancer. Acta Oncol. 1989;28:219–22.
Ensminger WD, Gyves JW, Stetson P, Walker-Andrews S. Phase I study of hepatic arterial degradable starch microspheres and mitomycin. Cancer Res. 1985;45:4464–7.
Koike S, Fujimoto S, Guhji M, Shrestha RD, Kokubun M, Kobayashi K, Kiuchi S, Konno C, Okui K. Effect of degradable starch microspheres (DSM) on hepatic hemodynamics. Gan To Kagaku Ryoho. 1989;16:2818–21.
Gyves JW, Ensminger WD, VanHarken D, Niederhuber J, Stetson P, Walker S. Improved regional selectivity of hepatic arterial mitomycin by starch microspheres. Clin Pharmacol Ther. 1983;34:259–65.
Pfeifle CE, Howell SB, Ashburn WL, Barone RM, Bookstein JJ. Pharmacologic studies of intra-hepatic artery chemotherapy with degradable starch microspheres. Cancer Drug Deliv. 1986;3:1–14.
Czejka M, Jäger W, Schüller J, Schernthaner G. Pharmakokinetik und lokale Verfügbarkeit von Mitomycin. Einfluss von Vasokonstriktion und Chemoembolisation. Arzneimittelforschung. 1991;41:260–3.
Domellöf L, Andersson M, Eksborg S. Hepatic arterial chemotherapy and embolisation with degradable starch microspheres. In: Cancer chemotherapy: challenges for the future. Oxford: Elsevier Science Publishers B.V; 1989.
Teder H, Nilsson B, Jonsson K. Hepatic arterial administration of doxorubicin (Adriamycin) with or without degradable starch microspheres: a pharmacokinetic study in man. In: Antracyclines and cancer therapy. Amsterdam: Excerpta Medica; 1983.
Dakhil S, Ensminger W, Cho K, Niederhuber J, Doan K, Wheeler R. Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer. 1982;50:631–5.
Bleiberg H, Pector J, Frühling J, Parmentier N, Gerard B, Gordon B, Ings R, Solere P, Lucas C. Hepatic intra-arterial fotemustine combined with degradable starch microspheres: pharmacokinetics in a phase I-II trial. Reg Cancer Treat. 1992;4:237–43.
Czejka MJ, Schüller J, Jäger W, Fogl U, Weiss C, Schernthaner G. Improvement of the local bioavailability of 5-fluorouracil; I: application of biodegradable microspheres and clinical pharmacokinetics. Int J Exp Clin Chemother. 1991:4(3):161.
Civalleri D, Esposito M, Fulco RA, Vannozzi M, Balletto N, DeCian F, Percivale PL, Merlo F. Liver and tumor uptake and plasma pharmacokinetic of arterial cisplatin administered with and without starch microspheres in patients with liver metastases. Cancer. 1991;68:988–94.
Tegeder I, Bräutigam L, Seegel M, Al-Dam A, Turowski B, Geisslinger G, Kovács AF. Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer. Clin Pharmacol Ther. 2003;73:417–26.
Morise Z, Sugioka A, Kato R, Fujita J, Hoshimoto S, Kato T. Transarterial chemoembolization with degradable starch microspheres, irinotecan, and mitomycin-C in patients with liver metastases. J Gastrointest Surg. 2006;10:249–58.
Rump AFE, Woschée U, Theisohn M, Fischbach R, Heindel W, Lackner K, Klaus W. Pharmacokinetics of intra-arterial mitomycin C in the chemoembolization treatment of liver metastases with polyvinylalcohol or degradable starch microspheres. Eur J Clin Pharmacol. 2002;58:459–65.
Pohlen U, Reszka R, Schneider P, Buhr HJ, Berger G. Stealth liposomal 5-fluorouracil with or without degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases. An animal study in VX-2 liver tumor-bearing rabbits. Anticancer Res. 2004;24:1699–704.
Pohlen U, Reszka R, Buhr HJ, Berger G. Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. An animal study in CC-531 liver tumor-bearing rats. Anticancer Res. 2011;31:147–52.
Teder H, Johansson CJ. The effect of different dosages of degradable starch microspheres (Spherex) on the distribution of doxorubicin regionally administered to the rat. Anticancer Res. 1993;13:2161–4.
Sigurdson ER, Ridge JA, Daly JM. Intra-arterial infusion of doxorubicin with degradable starch microspheres. Improvement of hepatic tumor drug uptake. Arch Surg. 1986;121:1277–81.
Thom AK, Zhang SZ, Deveney C, Daly JM. Effects of verapamil and degradable starch microspheres during hepatic artery infusion of doxorubicin. Surgery. 1990;107:552–9.
Teder H, Johansson CJ, d’Argy R, Lundin N, Gunnarsson PO. The effect of different dose levels of degradable starch microspheres (Spherex) on the distribution of a cytotoxic drug after regional administration to tumour-bearing rats. Eur J Cancer. 1995;31:1701–5.
Pohlen U, Berger G, Binnenhei M, Reszka R, Buhr HJ. Increased carboplatin concentration in liver tumors through temporary flow retardation with starch microspheres (Spherex) and gelatin powder (Gelfoam): an experimental study in liver tumor-bearing rabbits. J Surg Res. 2000;92:165–70.
Pohlen U, Rieger H, Meyer BT, Loddenkemper C, Buhr HJ, Heitland P, Koester HD, Schneider P. Chemoembolization of lung metastases–pharmacokinetic behaviour of carboplatin in a rat model. Anticancer Res. 2007;27:809–15.
Pohlen U, Buhr HJ, Berger G. Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: a study in CC-531 liver tumor-bearing WAG RIJ rats. Anticancer Res. 2011;31:153–9.
Thom AK, Sigurdson ER, Bitar M, Daly JM. Regional hepatic arterial infusion of degradable starch microspheres increases fluorodeoxyuridine (FUdR) tumor uptake. Surgery. 1989;105:383–92.
Hong K, Kobeiter H, Georgiades CS, Torbenson MS, Geschwind J-FH. Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer. J Vasc Interv Radiol. 2005;16:1711–7.
Hong K, Khwaja A, Liapi E, Torbenson MS, Georgiades CS, Geschwind J-FH. New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res. 2006;12:2563–7.
Gupta S, Wright KC, Ensor J, van Pelt CS, Dixon KA, Kundra V. Hepatic arterial embolization with doxorubicin-loaded superabsorbent polymer microspheres in a rabbit liver tumor model. Cardiovasc Intervent Radiol. 2011;34:1021–30.
Baylatry M-T, Pelage J-P, Wassef M, Ghegediban H, Joly A-C, Lewis A, Lacombe P, Fernandez C, Laurent A. Pulmonary artery chemoembolization in a sheep model: evaluation of performance and safety of irinotecan eluting beads (DEB-IRI). J Biomed Mater Res B Appl Biomater. 2011;98:351–9.
Rao PP, Pascale F, Seck A, Auperin A, Drouard-Troalen L, Deschamps F, Teriitheau C, Paci A, Denys A, Bize P, de Baere T. Irinotecan loaded in eluting beads: preclinical assessment in a rabbit VX2 liver tumor model. Cardiovasc Intervent Radiol. 2012;35(6):1448–59.
Lee K-H, Liapi EA, Cornell C, Reb P, Buijs M, Vossen JA, Ventura VP, Geschwind J-FH. Doxorubicin-loaded QuadraSphere microspheres: plasma pharmacokinetics and intratumoral drug concentration in an animal model of liver cancer. Cardiovasc Intervent Radiol. 2010;33:576–82.
Varela M, Real MI, Burrel M, Forner A, Sala M, Brunet M, Ayuso C, Castells L, Montañá X, Llovet JM, Bruix J. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol. 2007;46:474–81.
van Malenstein H, Maleux G, Vandecaveye V, Heye S, Laleman W, van Pelt J, Vaninbroukx J, Nevens F, Verslype C. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie. 2011;34:368–76.
Poggi G, Amatu A, Montagna B, Quaretti P, Minoia C, Sottani C, Villani L, Tagliaferri B, Sottotetti F, Rossi O, Pozzi E, Zappoli F, Riccardi A, Bernardo G. OEM-TACE: a new therapeutic approach in unresectable intrahepatic cholangiocarcinoma. Cardiovasc Intervent Radiol. 2009;32:1187–92.
Namur J, Citron SJ, Sellers MT, Dupuis MH, Wassef M, Manfait M, Laurent A. Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants. J Hepatol. 2011;55(6):1332–8.
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Czejka, M., Schüller, K. (2015). Pharmacokinetic Aspects of Regional Tumor Therapy. In: Van Cutsem, E., Vogl, T., Orsi, F., Sobrero, A. (eds) Locoregional Tumor Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36572-0_2
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