Abstract
Very similar to high-dose-rate (HDR) brachytherapy, pulsed-dose-rate (PDR) brachytherapy is delivered as an afterloading technique using a temporary implant. Several catheters or needles are implanted into the prostate according to a pretreatment plan. PDR brachytherapy is given as a boost to external beam radiotherapy. Treatment usually lasts about 48 h. Because catheters/needles can move during treatment, careful attention should be paid. Anchoring catheters in the prostate with specially designed anchoring catheters can be useful for this purpose. Because the treatment is delivered without the rectal ultrasound probe in, it is advisable to perform definitive treatment planning on CT scan or MRI.
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References
Brenner DJ, Hall EJ (1999) Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43:1095–1101
Brenner DJ, Martinez AA, Edmundson GK, Mitchell C, Thames HD, Armour EP (2002) Direct evidence that prostate tumors show high sensitivity to fractionation (low α/β ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys 52:6–13
Damore SJ, Syed N, Puthawala AA, Sharma A (2000) Needle displacement during HDR brachytherapy in the treatment of prostate cancer. Int J Radiat Oncol Biol Phys 46:1205–1211
Fowler J, Chapell R, Ritter M (2001) Is α/β for prostate tumors really low? Int J Radiat Oncol Biol Phys 50:1021–1031
Galalae RM, Kovács G, Schultze J et al (2002) Long-term outcome after elective irradiation of the pelvic lymphatics and local dose escalation using high-dose-rate brachytherapy for locally advanced prostate cancer. Int J Radiat Oncol Biol Phys 52:81–90
Geiger MH, Lotter M, Seeger AR, Sauer R, Strnad V (2008) Die alleinige interstitielle Pulse-Dose-Rate Brachytherapie in der Therapie des lokal begrenzten Prostatakarzinoms. Erfahungen hinsichtlich Durchführbarkeit und Toxizität. Strahlenther Onkol 184(Suppl 1):172
Lettmaier S, Lotter M, Kreppner S, Strnad A, Fietkau R, Strnad V (2012) Long term results of a prospective dose escalation phase-II trial: interstitial pulsed-dose-rate brachytherapy as a boost for intermediate- and high-risk prostate cancer. Radiother Oncol 104:181–186
Martinez AA, Pataki I, Edmundson G, Sebastian E, Brabbins D, Gustafson G (2001) Phase II prospective study of the use of conformal high-dose-rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: a feasibility report. Int J Radiat Oncol Biol Phys 49:61–69
Mullokandov E, Gejerman G (2004) Analysis of serial CT scans to assess template and catheter movement in prostate HDR brachytherapy. Int J Radiat Oncol Biol Phys 58:1063–1071
Nahum AE, Movsas B, Horwitz EM, Stobbe CC, Chapman JD (2003) Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the a/b ratio. Int J Radiat Oncol Biol Phys 57:391–401
Pieters BR, van der Grient JN, Blank LE, Koedooder K, de Hulshof MC, Reijke TM (2006) Minimal displacement of novel self-anchoring catheters suitable for temporary prostate implants. Radiother Oncol 80:69–72
Pieters BR, van de Kamer JB, van Herten YRJ et al (2008) Comparison of biologically equivalent dose–volume parameters for the treatment of prostate cancer with concomitant boost IMRT versus IMRT combined with brachytherapy. Radiother Oncol 88:46–52
Pieters BR, Rezaie E, Geijsen ED et al (2011) Development of late toxicity and IPSS resolution after external beam radiotherapy combined with PDR brachytherapy for prostate cancer. Int J Radiat Oncol Biol Phys 81:758–764
Pieters BR, Geijsen ED, Koedooder K et al (2011) Treatment results of PDR brachytherapy combined with external beam radiotherapy in 106 patients with intermediate- to high-risk prostate cancer. Int J Radiat Oncol Biol Phys 79:1037–1042
Valdagni R, Italia C, Montanaro P et al (2005) Is the alpha-beta ratio for prostate cancer really low? A prospective, non randomized trial comparing standard and hypofractionated conformal Âradiation therapy. Radiother Oncol 75:74–82
van Kal HB, Gellekom MPR (2003) How low is the α/β ratio for prostate cancer? Int J Radiat Oncol Biol Phys 57:1116–1121
Wang JZ, Guerrero M, Allen Li X (2003) How low is the α/β ratio for prostate cancer? Int J Radiat Oncol Biol Phys 55:194–203
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Pieters, B.R. (2013). Pulsed-Dose Rate Brachytherapy in Prostate Cancer. In: Kovács, G., Hoskin, P. (eds) Interstitial Prostate Brachytherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36499-0_8
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DOI: https://doi.org/10.1007/978-3-642-36499-0_8
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