Nomenclature
EC number
2.1.1.184
Systematic name
S-adenosyl-l-methionine:23S rRNA (adenine2085-N6)-dimethyltransferase
Recommended name
23S rRNA (adenine2085-N6)-dimethyltransferase
Synonyms
ErmC 23S rRNA methyltransferase <1> [7]
ErmC methyltransferase <1> [6]
ErmC’ <1> (<1> a naturally occuring variant of ErmC [3]) [3,4,6]
ErmC’ MTase <1> [6]
ErmC’ methyltransferase <1> [5,9]
ermC 23 S rRNA methyltransferase <1> [2]
ermC methylase <1> [2]
rRNA methyltransferase ErmC’ <1> [10]
rRNA:m6A methyltransferase ErmC’ <1> [4]
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References
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Denoya, C.D.; Bechhofer, D.H.; Dubnau, D.: Translational autoregulation of ermC 23S rRNA methyltransferase expression in Bacillus subtilis. J. Bacteriol., 168, 1133-1141 (1986)
Kadam, S.K.: Induction of ermC methylase in the absence of macrolide antibiotics and by pseudomonic acid A. J. Bacteriol., 171, 4518-4520 (1989)
Zhong, P.; Pratt, S.D.; Edalji, R.P.; Walter, K.A.; Holzman, T.F.; Shivakumar, A.G.; Katz, L.: Substrate requirements for ErmC’ methyltransferase activity. J. Bacteriol., 177, 4327-4332 (1995)
Schluckebier, G.; Zhong, P.; Stewart, K.D.: Kavanaugh, T.J.; Abad-Zapatero, C.: The 2.2 A structure of the rRNA methyltransferase ErmC’ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. J. Mol. Biol., 289, 277-291 (1999)
Maravic, G.; Bujnicki, J.M.; Feder, M.; Pongor, S.; Flögel, M.: Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC’ redefines the substrate-binding site and suggests a model for protein-RNA interactions. Nucleic Acids Res., 31, 4941-4949 (2003)
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Schomburg, D., Schomburg, I. (2013). 23S rRNA (adenine2085-N6)-dimethyltransferase 2.1.1.184. In: Schomburg, D., Schomburg, I. (eds) Class 2–3.2 Transferases, Hydrolases. Springer Handbook of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36240-8_22
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