Nomenclature
EC number
2.1.1.183
Systematic name
S-adenosyl-l-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
Recommended name
18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
Synonyms
18S rRNA dimethylase Dim1p <1> [1,4]
DIM1 <1> (<1> gene name [2]) [2]
Dim1p <1> [1,4]
KIDIM1 <2> [6]
ScDim1 <1> [3,5]
m2(6)A dimethylase <2> [6]
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References
Lafontaine, D.; Vandenhaute, J.; Tollervey, D.: The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. Genes Dev., 9, 2470-2481 (1995)
Lafontaine, D.; Delcour, J.; Glasser, A.L.; Desgres, J.; Vandenhaute, J.: The DIM1 gene responsible for the conserved \(\rm m^{6}_{2}Am^{6}_{2}A \) dimethylation in the 3’-terminal loop of 18 S rRNA is essential in yeast. J. Mol. Biol., 241, 492-497 (1994)
Pulicherla, N.; Pogorzala, L.A.; Xu, Z.; O’Farrell, H.C.; Musayev, F.N.; Scarsdale, J.N.; Sia, E.A.; Culver, G.M.; Rife, J.P.: Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. J. Mol. Biol., 391, 884-893 (2009)
Lafontaine, D.L.; Preiss, T.; Tollervey, D.: Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?. Mol. Cell. Biol., 18, 2360-2370 (1998)
O’Farrell, H.C.; Pulicherla, N.; Desai, P.M.; Rife, J.P.: Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. RNA, 12, 725-733 (2006)
Housen, I.; Demonte, D.; Lafontaine, D.; Vandenhaute, J.: Cloning and characterization of the KlDIM1 gene from Kluyveromyces lactis encoding the m2(6)A dimethylase of the 18S rRNA. Yeast, 13, 777-781 (1997)
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Schomburg, D., Schomburg, I. (2013). 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase 2.1.1.183. In: Schomburg, D., Schomburg, I. (eds) Class 2–3.2 Transferases, Hydrolases. Springer Handbook of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36240-8_21
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