Abstract
The majority of pharmacological agents used in clinical practice acts to alter the processes responsible for transmission, by facilitating or inhibiting: (1) release, (2) enzymatic degradation of the neurotransmitter or modulator, (3) function of specific postsynaptic receptors, (4) second messenger system, or (5) intracellular regulatory pathways. For example, N-type calcium ion channel blockers—derivatives of ω-conopeptides—interfere with the dynamics of cytosolic Ca 2+ i in the presynaptic nerve terminal. The decreased Ca 2+ i concentration prevents activation of calmodulin protein and movement of vesicles containing neurotransmitters toward to presynaptic membrane. Chemical agents that facilitate cholinergic and adrenergic neurotransmission can inhibit true and pseudo-acetylcholinesterase, monoamine oxidase, and catechol-O-methyltransferase enzymes in the synaptic cleft.
If (an experimentalist) had a needle to find in a haystack, he would proceed at once with the diligence of the bee to examine straw after straw until he found the object of his search…. A little theory and calculation would have saved him ninety per cent of his labor.
N. Tesla.
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Miftahof, R.N., Nam, H.G. (2013). Pharmacology of Detrusor Activity. In: Biomechanics of the Human Urinary Bladder. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36146-3_9
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DOI: https://doi.org/10.1007/978-3-642-36146-3_9
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