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Selenium Atom-Specific Mutagenesis (SAM) for Crystallography, DNA Nanostructure Design, and Other Applications

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Abstract

Since oxygen and selenium are in the same elemental family, the replacement of oxygen in nucleic acids with selenium does not significantly change the local as well as overall structures, which preserves the nucleic acid structures in a predictable manner. Furthermore, the valuable differences in chemical and electronic properties enable various functions and applications, including crystallization, phase determination, and high-resolution structure determination in X-ray crystallography, base-pair high fidelity, nanotechnology, and molecular imaging. This chapter briefly introduces the selenium-modified nucleic acids (SeNA), the selenium atom-specific mutagenesis (SAM), and their potentials in DNA nanotechnology.

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Acknowledgment

This work was financially supported by the Georgia Cancer Coalition (GCC) Distinguished Cancer Clinicians and Scientists and NIH (NIGMS-R01GM095881).

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  1. Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA

    Sibo Jiang, Huiyan Sun & Zhen Huang

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  1. Sibo Jiang
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Correspondence to Zhen Huang .

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  1. , Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China, People's Republic

    Chunhai Fan

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Jiang, S., Sun, H., Huang, Z. (2013). Selenium Atom-Specific Mutagenesis (SAM) for Crystallography, DNA Nanostructure Design, and Other Applications. In: Fan, C. (eds) DNA Nanotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36077-0_3

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