Abstract
A special case of our master equation, specialized for microsatellite mutations, was derived to study influence of bottlenecks in modern human history. Jorde and co-workers analyzed allele frequency distributions at 60 tetranucleotide loci in a worldwide survey of human populations. Kimmel and co-workers investigated whether there is imbalance between allele size variances and heterozygosity observed in these data, as analyzed by an imbalance index they introduced. Three major groups of population, Asians, Africans, and Europeans, were considered for this purpose. The analysis shows that the data are consistent with a population bottleneck in modern humanity history and gradual settling of Europe and Asia.
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Bobrowski, A., Kimmel, M. (2015). Motivating Example: Population Bottlenecks in the History of Modern Humans, Use of the Imbalance Index. In: An Operator Semigroup in Mathematical Genetics. SpringerBriefs in Applied Sciences and Technology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35958-3_3
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DOI: https://doi.org/10.1007/978-3-642-35958-3_3
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