Abstract
Organ morphogenesis requires coordinated communications between and within different populations of progenitors. Development of the mammalian asymmetric aortic arch artery tree is an excellent model system to study genes and mechanisms orchestrating complex inter-tissue interactions during organ morphogenesis. In this system, the initially symmetric vascular tree connecting the heart to the embryonic circulation undergoes asymmetric remodeling in a highly stereotyped manner. This morphogenetic process is essential for the separation of arterial and venous circulations and requires coordinated communication between cells of mesoderm, endoderm, surface ectoderm, and the neural crest. While a number of key signals have been identified, the means by which these signals are integrated to drive this morphogenetic process is not well understood. One possible means by which signaling by various growth factors can be integrated into precise developmental programs is via the extracellular matrix. This review will examine roles of extracellular matrix proteins in mediating growth factor signaling between neural crest cells and the surrounding tissues during development of the cardiac outflow tract and aortic arch arteries.
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Acknowledgments
I would like to thank Glenn Radice, Anne Moon, Jim Weston, and Dongying Chen for their critical comments and helpful suggestions. Studies in my lab are supported by the AHA Scientist Development grant, AHA Innovative Research grant, W.W. Smith Charitable foundation, and NIH NHLBI #5R01HL103920.
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Astrof, S. (2013). Interactions Between Neural Crest-Derived Cells and Extracellular Microenvironment During Cardiovascular Development. In: DeSimone, D., Mecham, R. (eds) Extracellular Matrix in Development. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35935-4_5
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