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Other Malignant Tumors of the Liver

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Part of the book series: Radiology Illustrated ((RADILL))

Abstract

Intrahepatic cholangiocarcinoma is the most common primary liver cancer except hepatocellular carcinoma. Intrahepatic cholangiocarcinomas can be classified into three types by morphology: mass-forming type, periductal infiltrative type, and intraductal papillary growth type. Mass-forming type is the most common and periductal infiltrative type is known to show the worst prognosis. Imaging findings of mass-forming-type intrahepatic cholangiocarcinoma overlap those of metastases of adenocarcinoma from gastrointestinal tract. Therefore, careful evaluation for the primary tumors other than liver cancer should be performed to diagnose cholangiocarcinoma. Biliary cystadenocarcinoma, epithelioid hemangioendothelioma, and sarcomas are rare malignant tumors of the liver. Unusual hepatic sarcomas frequently show large, solitary masses with central necrosis. Hepatic metastasis is the most common malignant tumor of non-cirrhotic liver. Accurate diagnosis of hepatic metastases gains more and more attention because complete resection or ablation of metastases has been proved to be effective for prolonging overall survival in some malignancies including colorectal cancer and neuroendocrine carcinomas. Hepatic metastases have various imaging features and resemble the imaging findings of the primary tumors. MRI was a problem-solving tool; however, it plays more important roles now and is superior to MDCT in terms of diagnostic performance for hepatic metastases. Liver is one of the most commonly involved organs of lymphomas, and majority of the cases are secondary lymphoma. Hepatic lymphomas can be divided into three groups by their appearance: large solitary masses, multiple nodules, and diffuse infiltrative type.

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Suggested Reading

  • Edge SB, Byrd DR, Compton CC, et al. Chapter 18 liver malignancy, Chapter 19 Intrahepatic bile duct malignancy. In: Edge SB, American Joint Committee on Cancer, editor. AJCC cancer staging manual. 7th ed. New York: Springer; 2009.

    Google Scholar 

  • Kim SJ, Lee JM, Han JK, et al. Peripheral mass-forming cholangiocarcinoma in cirrhotic liver. AJR Am J Roentgenol. 2007;186(6):1428–34.

    Google Scholar 

  • Choi BI, Lee JM, Han JK. Imaging of intrahepatic and hilar cholangiocarcinoma. Abdom Imaging. 2004;29(5):548–57.

    Google Scholar 

  • Han JK, Choi BI, Kim AY, et al. Cholangiocarcinoma: pictorial essay of CT and cholangiographic findings. Radiographics. 2002;22(1):173–87.

    Google Scholar 

  • Kang Y, Lee JM, Kim SH, Han JK, Choi BI. Intrahepatic mass-forming cholangiocarcinoma: enhancement patterns on gadoxetic acid-enhanced MR images. Radiology. 2012;263(3):751–60.

    Article  Google Scholar 

  • Takanami K, Yamada T, Tsuda M, et al. Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation. Abdom Imaging. 2011;36(4):447–56.

    Article  PubMed  Google Scholar 

  • Lim JH, Jang KT, Rhim H, Kim YS, Lee KT, Choi SH. Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. 2007;32(5):644–51.

    Article  PubMed  Google Scholar 

  • Allen RA, Lisa JR. Combined liver cell and bile duct carcinoma. Am J Pathol. 1949;25:647–55.

    CAS  PubMed  Google Scholar 

  • Ebied O, Federle MP, Blachar A, et al. Hepatocellular-cholangiocarcinoma: helical computed tomography findings in 30 patients. J Comput Assist Tomogr. 2003;27:117–24.

    Article  PubMed  Google Scholar 

  • Nishie A, Yoshimitsu K, Asayama Y, et al. Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT; comparison with histologic findings. AJR Am J Roentgenol. 2005;184:1157–62.

    Google Scholar 

  • Kim JY, Kim SH, Eun HW, et al. Differentiation between biliary cystic neoplasms and simple cysts of the liver: accuracy of CT. AJR Am J Roentgenol. 2010;195(5):1142–8.

    Google Scholar 

  • Bruegel M, Muenzel D, Waldt S, Specht K, Rummeny EJ. Hepatic epithelioid hemangioendothelioma: findings at CT and MRI including preliminary observation at diffusion-weighted echo-planar imaging. Abdom Imaging. 2011;36(4):415–24.

    Article  PubMed  Google Scholar 

  • Lyburn ID, Torreggiani WC, Harris AC, et al. Hepatic epithelioid hemangioendothelioma: sonographic, CT, and MR imaging appearances. AJR Am J Roentgenol. 2003;180(5):1359–94.

    Google Scholar 

  • Kitami M, Yamada T, Sato A, et al. Diffuse hepatic angiosarcoma with a portal venous supply mimicking hemangiomatosis. J Comput Assist Tomogr. 2003;27(4):626–9.

    Article  PubMed  Google Scholar 

  • Bruegel M, Muenzel D, Waldt S, Specht K, Rummeny EJ. Hepatic angiosarcoma: cross-sectional imaging findings in seven patients with emphasis on dynamic contrast-enhanced and diffusion-weighted MRI. Abdom Imaging. 2013;38(4):745–54. doi:10.1007/s00261-012-9967-2.

    Article  PubMed  Google Scholar 

  • Koyama T, Fletcher JG, Johnson CD, Kuo MS, Notohara K, Burgart LJ. Primary hepatic angiosarcoma: findings at CT and MR imaging. Radiology. 2002;222(3):667–73.

    Article  PubMed  Google Scholar 

  • Lashkari HP, Khan SU, Ali K, Sashikumar P, Mukherjee S. Diagnosis of undifferentiated embryonal sarcoma of the liver-importance of combined studies of ultrasound and CT scan. J Pediatr Hematol Oncol. 2009;31(10):797–8.

    Article  PubMed  Google Scholar 

  • Buetow PC, Buck JL, Pantongrag-Brown L, et al. Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. Radiology. 1997;203(3):779–83.

    CAS  PubMed  Google Scholar 

  • Tan Y, Xiao EH. Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with nalysis of 54 cases and review of the literature. Abdom Imaging. 2013;38(3):511–26. doi:10.1007/s00261-012-9918-y.

  • Chung EM, Lattin Jr GE, Cube R, et al. From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 2011;31(2):483–507.

    Article  PubMed  Google Scholar 

  • Lu M, Greer ML. Hypervascular multifocal hepatoblastoma: dynamic gadolinium-enhanced MRI findings indistinguishable from infantile hemangioendothelioma. Pediatr Radiol. 2007;37(6):587–91.

    Article  PubMed  Google Scholar 

  • Paulson EK. Evaluation of the liver for metastatic disease. Semin Liver Dis. 2001;21(2):225–36.

    Article  CAS  PubMed  Google Scholar 

  • Sica GT, Ji H, Ros PR. CT and MR imaging of hepatic metastases. AJR Am J Roentgenol. 2000;174(3):691–8.

    Article  CAS  PubMed  Google Scholar 

  • Kanematsu M, Kondo H, Goshima S, et al. Imaging liver metastases: review and update. Eur J Radiol. 2006;58(2):217–28.

    Article  PubMed  Google Scholar 

  • Semelka RC, Hussain SM, Marcos HB, et al. Perilesional enhancement of hepatic metastases: correlation between MR imaging and histopathologic findings-initial observations. Radiology. 2000;215:89–94.

    Article  CAS  PubMed  Google Scholar 

  • Seo HJ, Kim MJ, Lee JD, Chung WS, Kim YE. Gadoxetate disodium-enhanced magnetic resonance imaging versus contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of colorectal liver metastases. Invest Radiol. 2011;46(9):548–55.

    Google Scholar 

  • Seale MK, Catalano OA, Saini S, Hahn PF, Sahani DV. Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree. Radiographics. 2009;29(6):1725–48.

    Article  PubMed  Google Scholar 

  • Kim YK, Lee MW, Lee WJ, et al. Diagnostic accuracy and sensitivity of diffusion-weighted and of gadoxetic acid-enhanced 3-T MR imaging alone or in combination in the detection of small liver metastasis (≤1.5 cm in diameter). Invest Radiol. 2012;47(3):159–66.

    Google Scholar 

  • Maher MM, McDermott SR, Fenlon HM, et al. Imaging of primary non-Hodgkin’s lymphoma of the liver. Clin Radiol. 2011;56(4):295–301.

    Article  Google Scholar 

  • Gazelle GS, Lee MJ, Hahn PF, Goldberg MA, Rafaat N, Mueller PR. US, CT, and MRI of primary and secondary liver lymphoma. J Comput Assist Tomogr. 1994;18(3):412–15.

    Article  CAS  PubMed  Google Scholar 

  • Monill J, Pernas J, Montserrat E, et al. CT features of abdominal plasma cell neoplasms. Eur Radiol. 2005;15(8):1705–12.

    Article  CAS  PubMed  Google Scholar 

  • Nguyen BD, Dash N, Lupetin AR. MR imaging of hepatic plasmacytoma: a case report. Clin Imaging. 1992;16:98–101.

    Article  CAS  PubMed  Google Scholar 

  • Ng P, Slater S, Radvan G, Price A. Hepatic plasmacytomas: case report and review of imaging features. Australas Radiol. 1999;43:98–101.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Byung Ihn Choi .

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© 2014 Springer-Verlag Berlin Heidelberg

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Choi, JI., Choi, B.I. (2014). Other Malignant Tumors of the Liver. In: Choi, B. (eds) Radiology Illustrated: Hepatobiliary and Pancreatic Radiology. Radiology Illustrated. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35825-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-35825-8_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35824-1

  • Online ISBN: 978-3-642-35825-8

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