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Genetic Studies in Osteonecrosis of the Femoral Head

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Osteonecrosis

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Abstract

Osteonecrosis of the femoral head (ONFH) is a complex, polygenic, or multifactorial disease which is caused by a number of genetic factors of relatively smaller effects and environmental factors. Diverse conditions have been implicated in the development of ONFH. There are several well-accepted common associations: corticosteroids use [1], alcohol abuse [2], systemic lupus erythematosus [3], Legg-Calve-Perthes disease [4], sickle cell disease [5], radiation [6], cytotoxic agents [7], Gaucher disease [8], dysbarism [9], HIV [10], hyperlipidemia [11], pancreatitis [12], and gout [13]. Idiopathic ONFH refers only when there are no identifiable factors identified.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Musculoskeletal Genome Research Center, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea

    Shin-Yoon Kim

  2. Skeletal diseases Genome Research Center, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea

    Tae-Ho Kim

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Editors and Affiliations

  1. Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Kyonggi-do, Korea, Republic of (South Korea)

    Kyung-Hoi Koo

  2. Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, Baltimore, Maryland, USA

    Michael A. Mont

  3. Department of Orthopaedic Surgery, Department of Orthopaedic Surgery, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Lynne C. Jones

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Kim, SY., Kim, TH. (2014). Genetic Studies in Osteonecrosis of the Femoral Head. In: Koo, KH., Mont, M., Jones, L. (eds) Osteonecrosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35767-1_9

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