Abstract
The disease process of atraumatic osteonecrosis was first described as ischemic necrosis of the hip [1]. This pathological process can lead to destructive arthritis in multiple joints, most commonly occurring in the hips, knees, shoulders, and ankles [1]. Currently, there is no consensus on the pathophysiological mechanism of osteonecrosis, but it is thought to be multifactorial in nature. However, there are certain direct risk factors implicated in the development of osteonecrosis such as trauma, radiation, Caisson’s disease, and sickle cell disease [2]. In addition, various other risk factors have been shown to have a direct correlation with osteonecrosis such as corticosteroids, habitual alcohol intake, hyperlipidemia, chemotherapeutic agents, systemic lupus erythematosus, lipid storage diseases, and inflammatory bowel disease [3, 4].
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References
Johnson AJ, Mont MA, Tsao AK, Jones LC. Treatment of femoral head osteonecrosis in the united states: 16-year analysis of the nationwide inpatient sample. Clin Orthop Relat Res. 2013. doi:10.1007/s11999-013-3220-3.
Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am. 2006;88(5):1117–32. doi:10.2106/JBJS.E.01041. 88/5/1117 [pii].
Seguin C, Kassis J, Busque L, Bestawros A, Theodoropoulos J, Alonso ML, Harvey EJ. Non-traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia. Rheumatology (Oxford). 2008;47(8):1151–5. doi:10.1093/rheumatology/ken206.
Nakamura J, Harada Y, Oinuma K, Iida S, Kishida S, Takahashi K. Spontaneous repair of asymptomatic osteonecrosis associated with corticosteroid therapy in systemic lupus erythematosus: 10-year minimum follow-up with mri. Lupus. 2010;19(11):1307–14. doi:10.1177/0961203310372951. 0961203310372951 [pii].
Chandler GN, Wright V. Deleterious effect of intra-articular hydrocortisone. Lancet. 1958;2(7048):661–3.
Heimann WG, Freiberger RH. Avascular necrosis of the femoral and humeral heads after high-dosage corticosteroid therapy. New Engl J Med. 1960;263:672–5. doi:10.1056/NEJM196010062631404.
Sheng H, Sheng CJ, Cheng XY, Zhang G, Lee KM, Leung KS, Qu S, Qin L. Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis. Int J Clin Exp Pathol. 2013;6(6):1046–50.
Powell C, Chang C, Gershwin ME. Current concepts on the pathogenesis and natural history of steroid-induced osteonecrosis. Clin Rev Allergy Immunol. 2011;41(1):102–13. doi:10.1007/s12016-010-8217-z.
Felson DT, Anderson JJ. Across-study evaluation of association between steroid dose and bolus steroids and avascular necrosis of bone. Lancet. 1987;1(8538):902–6.
Shigemura T, Nakamura J, Kishida S, Harada Y, Ohtori S, Kamikawa K, Ochiai N, Takahashi K. Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: prospective mri study. Rheumatology (Oxford). 2011;50(11):2023–8. doi:10.1093/rheumatology/ker277.
Nagasawa K, Tada Y, Koarada S, Horiuchi T, Tsukamoto H, Murai K, Ueda A, Yoshizawa S, Ohta A. Very early development of steroid-associated osteonecrosis of femoral head in systemic lupus erythematosus: prospective study by MRI. Lupus. 2005;14(5):385–90. doi:10.1191/0961203305lu2103oa.
Shibatani M, Fujioka M, Arai Y, Takahashi K, Ueshima K, Okamoto M, Yoshimura N, Hirota Y, Fukushima W, Kubo T. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head. Acta Orthop. 2008;79(5):631–6. doi:10.1080/17453670810016641.
Ono K, Tohjima T, Komazawa T. Risk factors of avascular necrosis of the femoral head in patients with systemic lupus erythematosus under high-dose corticosteroid therapy. Clin Orthop Relat Res. 1992;277:89–97.
Li ZR, Sun W, Qu H, Zhou YX, Dou BX, Shi ZC, Zhang NF, Cheng XG, Wang DL, Guo WS. Clinical research of correlation between osteonecrosis and steroid. Zhonghua wai ke za zhi [Chin J Surg]. 2005;43(16):1048–53.
Sinha A, Bagga A. Pulse steroid therapy. Indian J Pediatr. 2008;75(10):1057–66. doi:10.1007/s12098-008-0210-7.
Ce P, Gedizlioglu M, Gelal F, Coban P, Ozbek G. Avascular necrosis of the bones: an overlooked complication of pulse steroid treatment of multiple sclerosis. Eur J Neurol. 2006;13(8):857–61. doi:10.1111/j.1468-1331.2006.01375.x.
Lausten GS, Jensen JS, Olgaard K. Necrosis of the femoral head after renal transplantation. Acta Orthop Scand. 1988;59(6):650–4.
Oinuma K, Harada Y, Nawata Y, Takabayashi K, Abe I, Kamikawa K, Moriya H. Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment. Ann Rheum Dis. 2001;60(12):1145–8.
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Cherian, J.J., Kapadia, B.H., Banerjee, S., Jauregui, J.J., Mont, M.A. (2014). Corticosteroid Usage and Osteonecrosis of the Hip. In: Koo, KH., Mont, M., Jones, L. (eds) Osteonecrosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35767-1_12
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