Abstract
Patients experience painless treatment in current health care since local anesthesia (LA) makes it possible for most procedures in ambulatory dentistry and oral and maxillofacial surgery. Modern local anesthetics are extremely efficient and safe drugs, and the great majority of patients encounter neither unpleasant side effects nor lasting local or systemic complications. Vasovagal syncope is a frequent psychogenic reaction experienced upon anesthetic injection that is unrelated to the particular drug used.
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Harn SD, Durham TM (1990) Incidence of lingual nerve trauma and postinjection complications in conventional mandibular block anaesthesia. J Am Dent Assoc 121:519–523
Pogrel MA (2007) Permanent nerve damage from inferior alveolar nerve blocks – an update to include articaine. J Calif Dent Assoc 34:271–273
Hillerup S, Jensen R (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35:437–443
Renton T, Adey-Viscuso D, Meechan JG, Yilmaz Z (2010) Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. Br Dent J 209(9):E15
Hillerup S (2007) Iatrogenic injury to oral branches of the trigeminal nerve: records of 449 cases. Clin Oral Investig 11(2):133–142
Hillerup S, Jensen RH, Ersboll BK (2011) Trigeminal nerve injury associated with injection of local anesthetics: needle lesion or neurotoxicity? J Am Dent Assoc 142(5):531–539
Pogrel MA, Thamby S (2000) Permanent nerve involvement resulting from inferior alveolar nerve blocks. J Am Dent Assoc 131:901–907
Pogrel MA, Bryan J, Regezi J (1995) Nerve damage associated with inferior alveolar nerve blocks. J Am Dent Assoc 126(8):1150–1155
Haas DA, Lennon D (1995) A 21 year retrospective study of reports of paresthesia following local anaesthetic administration. J Can Dent Assoc 61:319–330
Haas DA (2002) An update on local anesthetics in dentistry. J Can Dent Assoc 68(9):546–551
Gaffen AS, Haas DA (2009) Retrospective review of voluntary reports of nonsurgical paresthesia in dentistry. J Can Dent Assoc 75(8):579
Garisto GA, Gaffen AS, Lawrence HP, Tenenbaum HC, Haas DA (2010) Occurrence of paresthesia after dental local anesthetic administration in the United States. J Am Dent Assoc 141(7):836–844
Kalichman MW, Moorhouse DF, Powell HC, Myers RR (1993) Relative neural toxicity of local anesthetics. J Neuropathol Exp Neurol 52(3):234–240
Kroin J, Penn R, Levy F, Kerns J (1986) Effect of repetitive lidocaine infusion on peripheral nerve. Exp Neurol 94:166–173
Cornelius CP (1997) Nerveninjektionsschäden durch Lokalanaesthetika. Experimentelle Untersuchungen zur Neurotoxizität und Longitudinalausbreitung. Thesis ed. Tübingen
Cornelius CP, Roser M, Wiethölter H, Wolburg H (2000) Nerve injection injuries due to local anaesthetics. Experimental work. J Cranio Maxillofac Surg 28(suppl 3):134–135
Hillerup S, Bakke M, Larsen JO, Thomsen CE, Gerds TA (2011) Concentration-dependent neurotoxicity of articaine: an electrophysiological and stereological study of the rat sciatic nerve. Anesth Analg 112(6):1330–1338
Calatayud J, González Á (2003) History of the development and evolution of local anesthesia since the coca leaf. Anesthesiology 98(6):1503–1508
Baart JA, Brand HS editors (2009) Local anesthesia in dentistry, 2nd edn. Blackwell
Zink W, Graf BM (2003) Toxikologie der Lokalanästhetika. Patomechanismen – Klinik – Therapie. Anaesthetist 52:1102–1123
Bremer G, Ekmanner S (1948) Xylocaine; a new local anaesthetic. Br Dent J 85(12):278–281
Renton T, Yilmaz Z (2012) Managing iatrogenic trigeminal nerve injury: a case series and review of the literature. Int J Oral Maxillofac Surg 41:629–637
Hazell L, Shakir SA (2006) Under-reporting of adverse drug reactions: a systematic review. Drug Saf 29(5):385–396
Krafft TC, Hickel R (1994) Clinical investigation into the incidence of direct damage to the lingual nerve caused by local anaesthesia. J Craniomaxillofac Surg 22:294–296
Malamed SF, Gagnon S, Leblanc D (2001) Articaine hydrochloride: a study of the safety of a new amide local anaesthetic. J Am Dent Assoc 132:177–185
Dower JS (2007) Articaine vs. lidocaine. J Calif Dent Assoc 35:240–244
Haas DA (2006) Articaine and paraesthesia: epidemiological studies. J Am Coll Dent 73:5–10
Dower JS (2007) Anesthetic study questioned. J Am Dent Assoc 138:708–709
Malamed SF (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35(9):876–877
Pogrel MA (2007) Permanent nerve damage from inferior alveolar nerve blocks – an update to include articaine. J Calif Dent Assoc 35(4):271–273
Malamed SF (2007) Articaine versus lidocaine: the author responds. J Calif Dent Assoc 35:383–385
Fried K, Frisen J, Mozart M (1989) De- and regeneration of axons after minor lesions in the rat sciatic nerve. Effects of microneurography electrode penetrations. Pain 36(1):93–102
Kalichman MW, Powell HC, Myers RR (1989) Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve. J Pharmacol Exp Ther 250(1):406–413
Selander D (1993) Neurotoxicity of local anesthetics: animal data. Reg Anesth 18(6 Suppl):461–468
Kalichman MW (1993) Physiologic mechanisms by which local anesthetics may cause injury to nerve and spinal cord. Reg Anesth 18(6 Suppl):448–452
European Medicines Agency (2009) Periodic safety update report on articaine, nervous system disorders. Source: Danish Medicines Agency 2009
Bagheri SC, Meyer RA, Khan HA, Kuhmichel A, Steed MB (2010) Retrospective review of microsurgical repair of 222 lingual nerve injuries. J Oral Maxillofac Surg 68:715–723
Hillerup S, Stoltze K (2007) Lingual nerve injury II. Observations on sensory recovery after micro-neurosurgical reconstruction. Int J Oral Maxillofac Surg 36(12):1139–1145
Robinson PP, Loescher AR, Smith KG (2000) A prospective, quantitative study on the clinical outcome of lingual nerve repair. Br J Oral Maxillofac Surg 38:255–263
Zuniga JR, Chen N, Philips CL (1997) Chemosensory and somatosensory regeneration after lingual nerve repair in humans. J Oral Maxillofac Surg 55:2–13
Dworkin RH, O’Connor AB, Backonja M et al (2007) Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132(3):237–251
Moore TJ (1995) Deadly medicine, why tens of thousands of heart patients died in America’s worst drug disaster. 1st edn. Simon & Schuster, New York. http://www.medicine.ox.ac.uk/bandolier/band23/b23-8.html
Kanaa MD, Whitworth JM, Meechan JG (2012) A comparison of the efficacy of 4 % articaine with 1:100,000 epinephrine and 2 % lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary teeth with irreversible pulpitis. J Endod 38(3):279–282
Silva LC, Santos TD, Santos JA, Maia MC, Mendonça CG (2012) Articaine versus lidocaine for third molar surgery: a randomized clinical study. Med Oral Patol Oral Cir Bucal 17(1):140–145
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Hillerup, S. (2013). Injection Injuries of the Trigeminal Nerve. In: Miloro, M. (eds) Trigeminal Nerve Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35539-4_4
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DOI: https://doi.org/10.1007/978-3-642-35539-4_4
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