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Bremsstrahlung SPECT/CT

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Abstract

The first bremsstrahlung imaging was performed early 1966 by Simon et al. [1, 2] using a rectilinear scanner following a liver radioembolisation via the hepatic artery with 90Y loaded 15 μm diameter microspheres. Although of very low quality, this imaging already provided the main information: the carcinoid tumours were well preferentially targeted (Fig. 13.1).

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References

  1. Simon N, Feitelberg S, Warner RRP, Greenspan EM, Edelman S, Baron MG. External scanning of internal beta-emitters. J Mt Sinai Hosp. 1966;33:365–70.

    CAS  Google Scholar 

  2. Simon N, Feitelberg S. Scanning bremsstrahlung of yttrium-90 microspheres injected intra-arterially. Radiology. 1967;88:719–24.

    PubMed  CAS  Google Scholar 

  3. Kaplan WD, Zimmerman RE, Bloomer WD, Knapp RC, Adelstein AJ. Therapeutic intraperitoneal 32P: a clinical assessment of the dynamics of distribution. Radiology. 1981;138:683.

    PubMed  CAS  Google Scholar 

  4. Lhommel R, Goffette P, Van den Eynde M, Jamar F, Pauwels S, Bilbao JI, Walrand S. Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT. Eur J Nucl Med Mol Imaging. 2009;36(10):1969.

    Google Scholar 

  5. Lhommel R, van Elmbt L, Goffette P, Van den Eynde M, Jamar F, Pauwels S, Walrand S. Feasibility of yttrium-90 TOF-PET based dosimetry in liver metastasis therapy using SIR-spheres. Eur J Nucl Med Mol Imaging. 2010;37(9):1654–62.

    Article  PubMed  Google Scholar 

  6. Walrand S, Jamar F, van Elmbt L, Lhommel R, Bidja’a Bekonde E, Pauwels S. 4-step renal dosimetry dependent on cortex geometry applied to 90Y peptide receptor radiotherapy: evaluation using a fillable kidney phantom imaged by 90Y PET. J Nucl Med. 2010;51:1969–73.

    Article  PubMed  Google Scholar 

  7. Walrand S, Flux GD, Konijnenberg MW, Valkema R, Krenning EP, Lhommel R, Pauwels S, Jamar F. Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: (86)Y or (90)Y imaging? Eur J Nucl Med Mol Imaging. 2011;38(1):S57–68.

    Article  PubMed  Google Scholar 

  8. Van Holen R, Staelens S, Vandenberghe S. SPECT imaging of high energy isotopes and isotopes with high energy contaminants with rotating slat collimators. Med Phys. 2009;36:4257–67.

    Article  PubMed  Google Scholar 

  9. Walrand S, Hesse S, Demonceau G, Pauwels S, Jamar F. Yttrium-90 labeled microspheres tracking during liver selective internal radiotherapy by bremsstrahlung pinhole SPECT: feasibility study and evaluation in an abdominal phantom. EJNMMI Res. 2011;1:32.

    Article  PubMed  Google Scholar 

  10. Heard S, Flux GD, Guy MJ, Ott RJ. Monte Carlo simulation of 90Y bremsstrahlung imaging. IEEE Nucl Sci Symp Conf Rec. 2004;6:3579–83.

    Google Scholar 

  11. Siegel JA. Quantitative bremsstrahlung SPECT imaging: attenuation-corrected activity determination. J Nucl Med. 1994;35(7):1213–6.

    PubMed  CAS  Google Scholar 

  12. Minarik D, Sjogreen Gleisner K, Ljungberg M. Evaluation of quantitative (90) Y SPECT based on experimental phantom studies. Phys Med Biol. 2008;53:5689–703.

    Article  PubMed  CAS  Google Scholar 

  13. Frey EC, Tsui BMW. A new method for modeling the spatially variant, object-dependent scatter response function in SPECT. IEEE Nucl Sci Symp. 1996;2:1082–6.

    Google Scholar 

  14. Minarik D, Sjӧgreen-Gleisner K, Linden O, Winga K, Tennvall J, Strand S-E, Ljungberg M. 90Y Bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy. J Nucl Med. 2010;51:1974–8.

    Article  PubMed  Google Scholar 

  15. Ronga X, Du Y, Ljungberg M, Rault E, Vandenberghe S, Frey EC. Development and evaluation of an improved quantitative 90Y bremsstrahlung SPECT method. Med Phys. 2012;39:2346–58.

    Article  Google Scholar 

  16. Walrand SH, van Elmbt LR, Pauwels S. Quantitation in SPECT using an effective model of the scattering. Phys Med Biol. 1994;39(4):719–34.

    Article  PubMed  CAS  Google Scholar 

  17. X-ray wavelengths for Spectrometer. 4th ed. X-ray department, General Electric Company; 1966.

    Google Scholar 

  18. Gupta T, Virmani S, Neidt TM, Szolc-Kowalska B, Sato KT, Ryu RK, Lewandowski RJ, Gates VL, Woloschak GE, Salem R, Omary RA, Larson AC. MR tracking of iron-labeled glass radioembolization microspheres during transcatheter delivery to rabbit VX2 livers tumors: feasibility study. Radiology. 2008;249(3):845–54.

    Article  PubMed  Google Scholar 

  19. Adler JR, Chang SD, Murphy MJ, Doty J, Geis P, Hancock SL. The cyberknife: a frameless robotic system for radiosurgery. Stereotact Funct Neurosurg. 1997;69:124–8.

    Article  PubMed  Google Scholar 

  20. Barber TW, Yap KS, Kalff V. PET/CT imaging of 90Y radiation synovectomy. Eur J Nucl Med Mol Imaging. 2012;39(5):917–8.

    Article  PubMed  Google Scholar 

  21. Riaz A, Lewandowski RJ, Kulik LM, Mulcahy MF, Sato KT, Ryu RK, et al. Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review. J Vasc Interv Radiol. 2009;29:1121–30.

    Article  Google Scholar 

  22. Ahmadzadehfar H, Muckle M, Sabet A, Wilhelm K, Kuhl C, Biermann K, Haslerud T, Biersack HJ, Ezziddin S. The significance of bremsstrahlung SPECT/CT after yttrium-90 radioembolization treatment in the prediction of extrahepatic side effects. Eur J Nucl Med Mol Imaging. 2011;39:309–15.

    Article  Google Scholar 

  23. Barone R, Borson-Chazot F, Valkema R, Walrand S, Chauvin F, Gogou L, Kvols LK, Krenning EP, Jamar F, Pauwels S. Patient-specific dosimetry in predicting renal toxicity with (90)Y-DOTATOC: relevance of kidney volume and dose rate in finding a dose-effect relationship. J Nucl Med. 2005;46:99S–106.

    PubMed  CAS  Google Scholar 

  24. Fabbri C, Sarti G, Agostini M, Di Dia A, Paganelli G. SPECT/CT 90Y-bremsstrahlung images for dosimetry during therapy. Ecancermedicalscience. 2008;2:106.

    PubMed  CAS  Google Scholar 

  25. Fabbri C, Sarti G, Cremonesi M, Ferrari M, Di Dia A, Agostini M, Botta F, Paganelli G. Quantitative analysis of 90Y bremsstrahlung SPECT-CT images for application to 3D patient-specific dosimetry. Cancer Biother Radiopharm. 2009;24(1):145–54.

    Article  PubMed  CAS  Google Scholar 

  26. Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76.

    Article  PubMed  Google Scholar 

  27. Walrand S, Jamar F. Perspectives in nuclear medicine tomography: a physicist’s point of view. In: Giussani A, editor. Imaging in nuclear medicine. Berlin/Heidelberg: Springer; 2013.

    Google Scholar 

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Correspondence to Stephan Walrand PhD .

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Walrand, S. (2014). Bremsstrahlung SPECT/CT. In: Ahmadzadehfar, H., Biersack, HJ. (eds) Clinical Applications of SPECT-CT. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35283-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-35283-6_13

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