Skip to main content

Frakturbiologie und -morphologie

  • Chapter
  • First Online:
Die proximale Humerusfraktur

Zusammenfassung

Im Rahmen der Frakturheilung nehmen in erster Linie biologische Faktoren eine zentrale Rolle ein. Dies gilt sowohl für die konservative als auch für die operative Frakturbehandlung. Bei der operativen Versorgung gewinnen zusätzlich mechanische und implantatspezifische Faktoren an Bedeutung. Aus biologischer Sicht ist die Vaskularität prioritär zu betrachten. Knochenbruchheilung setzt eine suffiziente Durchblutung der Fragmente voraus. Demineralisierung mit Remodeling von kortikalem und spongiösem Knochengewebe, fibroblastische Organisation des Frakturhämatoms, Kallusformation und Neoangiogenese sind biologische Prozesse im Rahmen der Frakturkonsolidierung, bei denen eine intakte Vaskularisation Grundvoraussetzung ist. Daher ist eine gewisse Kenntnis der Humeruskopfdurchblutung essenziell, um das Risiko einer posttraumatischen avaskulären Kopfnekrose besser einschätzen zu können sowie relevante Strukturen im Rahmen einer kopferhaltenden operativen Versorgung zu schonen und zu wahren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Allen MR, Hock JM, Burr DB (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35:1003–1012

    Article  CAS  PubMed  Google Scholar 

  • Andary JL, Petersen SA (2002) The vascular anatomy of the glenohumeral capsule and ligaments: an anatomic study. J Bone Joint Surg Am 84-A(12):2258–2265

    PubMed  Google Scholar 

  • Barvencik F, Gebauer M, Beil FT et al. (2010) Age- and sex-related changes of humeral head microarchitecture: histomorphometric analysis of 60 human specimens. J Orthop Res 28:18–26

    PubMed  Google Scholar 

  • Bastian JD, Hertel R (2008) Initial post-fracture humeral head ischemia does not predict development of necrosis. J Shoulder Elbow Surg 17:2–8

    Article  PubMed  Google Scholar 

  • Bernstein J, Adler LM, Blank JE et al. (1996) Evaluation of the Neer system of classification of proximal humeral fractures with computerized tomographic scans and plain radiographs. J Bone Joint Surg Am 78:1371–1375

    CAS  PubMed  Google Scholar 

  • Bostrom MP (1998) Expression of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res:S116–S123

    Google Scholar 

  • Brien H, Noftall F, Macmaster S et al. (1995) Neer’s classification system: a critical appraisal. J Trauma 38:257–260

    Article  CAS  PubMed  Google Scholar 

  • Brommage R, Hotchkiss CE, Lees CJ et al. (1999) Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys. J Clin Endocrinol Metab 84:3757–3763

    CAS  PubMed  Google Scholar 

  • Brooks CH, Revell WJ, Heatley FW (1993) Vascularity of the humeral head after proximal humeral fractures. An anatomical cadaver study. J Bone Joint Surg Br 75:132–136

    CAS  PubMed  Google Scholar 

  • Brorson S, Bagger J, Sylvest A et al. (2002a) Improved interobserver variation after training of doctors in the Neer system. A randomised trial. J Bone Joint Surg Br 84:950–954

    Article  CAS  PubMed  Google Scholar 

  • Brorson S, Bagger J, Sylvest A et al. (2002b) Low agreement among 24 doctors using the Neer-classification; only moderate agreement on displacement, even between specialists. Int Orthop 26:271–273

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Brunner A, Honigmann P, Treumann T et al. (2009) The impact of stereo-visualisation of three-dimensional CT datasets on the inter- and intraobserver reliability of the AO/OTA and Neer classifications in the assessment of fractures of the proximal humerus. J Bone Joint Surg Br 91:766–771

    Article  CAS  PubMed  Google Scholar 

  • Claes L, Eckert-Hubner K, Augat P (2002) The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 20:1099–1105

    Article  PubMed  Google Scholar 

  • Claes L, Eckert-Hubner K, Augat P (2003) The fracture gap size influences the local vascularization and tissue differentiation in callus healing. Langenbecks Arch Surg 388:316–322

    Article  PubMed  Google Scholar 

  • Codman E (1934) Fractures in relation to the subacromial bursa. In: Codman E (Hrsg) The shoulder, rupture of the supraspinatus tendon and other lesions in or about the subacromial bursa. Krieger, Malabar, S 313–331

    Google Scholar 

  • Court-Brown CM, Garg A, Mcqueen MM (2001) The epidemiology of proximal humeral fractures. Acta Orthop Scand 72:365–371

    Article  CAS  PubMed  Google Scholar 

  • D’elia G, Roselli G, Cavalli L et al. (2010) Severe osteoporosis: diagnosis of non-hip non-vertebral (NHNV) fractures. Clin Cases Miner Bone Metab 7:85–90

    PubMed Central  PubMed  Google Scholar 

  • De La Garza O, Lierse W, Steiner D (1992) Anatomical study of the blood supply in the human shoulder region. Acta Anat (Basel) 145:412–415

    Article  Google Scholar 

  • Diederichs G, Korner J, Goldhahn J et al. (2006) Assessment of bone quality in the proximal humerus by measurement of the contralateral site: a cadaveric analyze. Arch Orthop Trauma Surg 126:93–100

    Article  PubMed  Google Scholar 

  • Duparc F (2008) Proximal humerus arterial blood revisited. In: Boileau PW, Molè D et al. (Hrsg) Proximal humerus fractures and fractures sequelae. Sauramps Medical, Montpellier, S 31–37

    Google Scholar 

  • Duparc F, Muller JM, Freger P (2001) Arterial blood supply of the proximal humeral epiphysis. Surg Radiol Anat 23:185–190

    Article  CAS  PubMed  Google Scholar 

  • Edelberg JM, Reed MJ (2003) Aging and angiogenesis. Front Biosci 8:s1199–s1209

    Article  CAS  PubMed  Google Scholar 

  • Edelson G, Safuri H, Salami J et al. (2008) Natural history of complex fractures of the proximal humerus using a three-dimensional classification system. J Shoulder Elbow Surg 17:399–409

    Article  PubMed  Google Scholar 

  • Foruria AM, De Gracia MM, Larson DR et al. (2011) The pattern of the fracture and displacement of the fragments predict the outcome in proximal humeral fractures. J Bone Joint Surg Br 93:378–386

    Article  CAS  PubMed  Google Scholar 

  • Gerber C, Schneeberger AG, Vinh TS (1990) The arterial vascularization of the humeral head. An anatomical study. J Bone Joint Surg Am 72:1486–1494

    CAS  PubMed  Google Scholar 

  • Glowacki J (1998) Angiogenesis in fracture repair. Clin Orthop Relat Res:S82–S89

    Google Scholar 

  • Gumina S, Giannicola G, Albino P et al. (2011) Comparison between two classifications of humeral head fractures: Neer and AO-ASIF. Acta Orthop Belg 77:751–757

    PubMed  Google Scholar 

  • Grechenig W, Pichler W, Weiglein A (2008) Frakturen des proximalen Humerus. Mögliche Ursachen von Fehlschlägen bei Osteosynthesen. Trauma Berufskrankh 10 (Suppl 1): 53-8

    Article  Google Scholar 

  • Habermeyer P, Schweiberer L (1989) Fractures of the proximal humerus. Orthopade 18:200–207

    CAS  PubMed  Google Scholar 

  • Hardeman F, Bollars P, Donnelly M et al. (2012) Predictive factors for functional outcome and failure in angular stable osteosynthesis of the proximal humerus. Injury 43:153–158

    Article  PubMed  Google Scholar 

  • Hee HT, Wong HP, Low YP et al. (2001) Predictors of outcome of floating knee injuries in adults: 89 patients followed for 2-12 years. Acta Orthop Scand 72:385–394

    Article  CAS  PubMed  Google Scholar 

  • Hepp P, Theopold J, Osterhoff G et al. (2009) Bone quality measured by the radiogrammetric parameter „cortical index“ and reoperations after locking plate osteosynthesis in patients sustaining proximal humerus fractures. Arch Orthop Trauma Surg 129:1251–1259

    Article  PubMed  Google Scholar 

  • Hertel R (2005) Fractures of the proximal humerus in osteoporotic bone. Osteoporos Int 16 (Suppl 2):S65–S72

    Article  PubMed  Google Scholar 

  • Hertel R, Hempfing A, Stiehler M et al. (2004) Predictors of humeral head ischemia after intracapsular fracture of the proximal humerus. J Shoulder Elbow Surg 13:427–433

    Article  CAS  PubMed  Google Scholar 

  • Hettrich CM, Boraiah S, Dyke JP et al. (2010) Quantitative assessment of the vascularity of the proximal part of the humerus. J Bone Joint Surg Am 92:943–948

    Article  PubMed  Google Scholar 

  • Hirzinger C, Tauber M, Resch H (2011) Proximal humerus fracture: new aspects in epidemiology, fracture morphology, and diagnostics. Unfallchirurg 114:1051–1058

    Article  CAS  PubMed  Google Scholar 

  • Jones DB, Nolte H, Scholubbers JG et al. (1991) Biochemical signal transduction of mechanical strain in osteoblast-like cells. Biomaterials 12:101–110

    Article  CAS  PubMed  Google Scholar 

  • Joyce ME, Roberts AB, Sporn MB et al. (1990) Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110:2195–2207

    Article  CAS  PubMed  Google Scholar 

  • Kannus P, Palvanen M, Niemi S et al. (2009) Rate of proximal humeral fractures in older Finnish women between 1970 and 2007. Bone 44:656–659

    Article  PubMed  Google Scholar 

  • Kirchen ME, O’connor KM, Gruber HE et al. (1995) Effects of microgravity on bone healing in a rat fibular osteotomy model. Clin Orthop Relat Res:231–242

    Google Scholar 

  • Kralinger F, Unger S, Wambacher M et al. (2009) The medial periosteal hinge, a key structure in fractures of the proximal humerus: a biomechanical cadaver study of its mechanical properties. J Bone Joint Surg Br 91:973–976

    Article  CAS  PubMed  Google Scholar 

  • Krappinger D, Roth T, Gschwentner M et al. (2012) Preoperative assessment of the cancellous bone mineral density of the proximal humerus using CT data. Skeletal Radiol 41:299–304

    Article  PubMed  Google Scholar 

  • Kristiansen B, Andersen UL, Olsen CA et al. (1988) The Neer classification of fractures of the proximal humerus. An assessment of interobserver variation. Skeletal Radiol 17:420–422

    Article  CAS  PubMed  Google Scholar 

  • Kuiper JW, Van Kuijk C, Grashuis JL et al. (1996) Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro. Osteoporos Int 6:25–30

    Article  CAS  PubMed  Google Scholar 

  • Laing PG (1956) The arterial supply of the adult humerus. J Bone Joint Surg Am 38:1105–1116

    PubMed  Google Scholar 

  • Lill H, Hepp P, Gowin W et al. (2002) Age- and gender-related distribution of bone mineral density and mechanical properties of the proximal humerus. Rofo 174:1544–1550

    Article  CAS  PubMed  Google Scholar 

  • Lill H, Hepp P, Korner J et al. (2003) Proximal humeral fractures: how stiff should an implant be? A comparative mechanical study with new implants in human specimens. Arch Orthop Trauma Surg 123:74–81

    CAS  PubMed  Google Scholar 

  • Mahadeva D, Dias RG, Deshpande SV et al. (2011) The reliability and reproducibility of the Neer classification system--digital radiography (PACS) improves agreement. Injury 42:339–342

    Article  CAS  PubMed  Google Scholar 

  • Majed A, Macleod I, Bull AM et al. (2011) Proximal humeral fracture classification systems revisited. J Shoulder Elbow Surg 20:1125–1132

    Article  PubMed  Google Scholar 

  • Menck J, Dobler A, Dohler JR (1997) Vascularization of the humerus. Langenbecks Arch Chir 382:123–127

    CAS  PubMed  Google Scholar 

  • Meyer C, Alt V, Hassanin H et al. (2005) The arteries of the humeral head and their relevance in fracture treatment. Surg Radiol Anat 27:232–237

    Article  CAS  PubMed  Google Scholar 

  • Meyer RA, Jr., Meyer MH, Tenholder M et al. (2003) Gene expression in older rats with delayed union of femoral fractures. J Bone Joint Surg Am 85-A(7):1243–1254

    PubMed  Google Scholar 

  • Midura RJ, Su X, Morcuende JA et al. (2003) Parathyroid hormone rapidly stimulates hyaluronan synthesis by periosteal osteoblasts in the tibial diaphysis of the growing rat. J Biol Chem 278:51462–51468

    Article  CAS  PubMed  Google Scholar 

  • Mizumoto Y, Moseley T, Drews M et al. (2003) Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7. J Bone Joint Surg Am 85-A (Suppl 3):124–130

    PubMed  Google Scholar 

  • Müller ME, Nazarian SK, Koch P, Schatzker, J (Hrsg) (1990) The comprehensive classification of fractures of long bones. Springer, Berlin

    Google Scholar 

  • Neer CS, 2nd (1970) Displaced proximal humeral fractures. I. Classification and evaluation. J Bone Joint Surg Am 52:1077–1089

    PubMed  Google Scholar 

  • Nieminen S, Nurmi M, Satokari K (1981) Healing of femoral neck fractures; influence of fracture reduction and age. Ann Chir Gynaecol 70:26–31

    CAS  PubMed  Google Scholar 

  • Olschewski E, Murray P, Buckley R et al. (2001) Assessment of osteoporosis using standard radiographs of the wrist. J Trauma 51:912–916

    Article  CAS  PubMed  Google Scholar 

  • Osterhoff G, Diederichs G, Tami A et al. (2012) Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures. Arch Orthop Trauma Surg 132:509–515

    Article  PubMed  Google Scholar 

  • Palvanen M, Kannus P, Niemi S et al. (2006) Update in the epidemiology of proximal humeral fractures. Clin Orthop Relat Res 442:87–92

    Article  PubMed  Google Scholar 

  • Reddi AH (2001) Bone morphogenetic proteins: from basic science to clinical applications. J Bone Joint Surg Am 83-A (Suppl 1):S1–S6

    PubMed  Google Scholar 

  • Reed MJ, Edelberg JM (2004) Impaired angiogenesis in the aged. Sci Aging Knowledge Environ 2004:pe7

    Google Scholar 

  • Rhinelander FW (1979) Vascular proliferation and blood supply during fracture healing. In: Brooker AF, Edwards CC (Hrsg) External fixation: the current state of the art. Williams & Wilkins, Baltimore

    Google Scholar 

  • Sciadini MF, Dawson JM, Banit D et al. (2000) Growth factor modulation of distraction osteogenesis in a segmental defect model. Clin Orthop Relat Res:266–277

    Google Scholar 

  • Seebeck J, Goldhahn J, Stadele H et al. (2004) Effect of cortical thickness and cancellous bone density on the holding strength of internal fixator screws. J Orthop Res 22:1237–1242

    Article  CAS  PubMed  Google Scholar 

  • Sidor ML, Zuckerman JD, Lyon T et al. (1993) The Neer classification system for proximal humeral fractures. An assessment of interobserver reliability and intraobserver reproducibility. J Bone Joint Surg Am 75:1745–1750

    CAS  PubMed  Google Scholar 

  • Siebenrock KA, Gerber C (1993) The reproducibility of classification of fractures of the proximal end of the humerus. J Bone Joint Surg Am 75:1751–1755

    CAS  PubMed  Google Scholar 

  • Sjoden GO, Movin T, Guntner P et al. (1997) Poor reproducibility of classification of proximal humeral fractures. Additional CT of minor value. Acta Orthop Scand 68:239–242

    Article  CAS  PubMed  Google Scholar 

  • Sjoden GO, Movin T, Aspelin P et al. (1999) 3-D-radiographic analysis does not improve the Neer and AO classifications of proximal humeral fractures. Acta Orthop Scand 70:325–328

    Article  CAS  PubMed  Google Scholar 

  • Solberg BD, Moon CN, Franco DP et al. (2009) Locked plating of 3- and 4-part proximal humerus fractures in older patients: the effect of initial fracture pattern on outcome. J Orthop Trauma 23:113–119

    Article  PubMed  Google Scholar 

  • Tingart MJ, Apreleva M, Von Stechow D et al. (2003a) The cortical thickness of the proximal humeral diaphysis predicts bone mineral density of the proximal humerus. J Bone Joint Surg Br 85:611–617

    Article  Google Scholar 

  • Tingart MJ, Bouxsein ML, Zurakowski D et al. (2003b) Three-dimensional distribution of bone density in the proximal humerus. Calcif Tissue Int 73:531–536

    Article  CAS  Google Scholar 

  • Wallace AL, Draper ER, Strachan RK et al. (1994) The vascular response to fracture micromovement. Clin Orthop Relat Res:281–290

    Google Scholar 

  • Warriner AH, Patkar NM, Curtis JR et al. (2011) Which fractures are most attributable to osteoporosis? J Clin Epidemiol 64:46–53

    Article  PubMed  Google Scholar 

  • Yudell RM, Block MS (2000) Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg 58:761–766

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tauber, M., Resch, H. (2014). Frakturbiologie und -morphologie. In: Lill, H., Scheibel, M., Voigt, C. (eds) Die proximale Humerusfraktur. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35257-7_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-35257-7_1

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35256-0

  • Online ISBN: 978-3-642-35257-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics