Zusammenfassung
Im Rahmen der Frakturheilung nehmen in erster Linie biologische Faktoren eine zentrale Rolle ein. Dies gilt sowohl für die konservative als auch für die operative Frakturbehandlung. Bei der operativen Versorgung gewinnen zusätzlich mechanische und implantatspezifische Faktoren an Bedeutung. Aus biologischer Sicht ist die Vaskularität prioritär zu betrachten. Knochenbruchheilung setzt eine suffiziente Durchblutung der Fragmente voraus. Demineralisierung mit Remodeling von kortikalem und spongiösem Knochengewebe, fibroblastische Organisation des Frakturhämatoms, Kallusformation und Neoangiogenese sind biologische Prozesse im Rahmen der Frakturkonsolidierung, bei denen eine intakte Vaskularisation Grundvoraussetzung ist. Daher ist eine gewisse Kenntnis der Humeruskopfdurchblutung essenziell, um das Risiko einer posttraumatischen avaskulären Kopfnekrose besser einschätzen zu können sowie relevante Strukturen im Rahmen einer kopferhaltenden operativen Versorgung zu schonen und zu wahren.
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Literatur
Allen MR, Hock JM, Burr DB (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35:1003–1012
Andary JL, Petersen SA (2002) The vascular anatomy of the glenohumeral capsule and ligaments: an anatomic study. J Bone Joint Surg Am 84-A(12):2258–2265
Barvencik F, Gebauer M, Beil FT et al. (2010) Age- and sex-related changes of humeral head microarchitecture: histomorphometric analysis of 60 human specimens. J Orthop Res 28:18–26
Bastian JD, Hertel R (2008) Initial post-fracture humeral head ischemia does not predict development of necrosis. J Shoulder Elbow Surg 17:2–8
Bernstein J, Adler LM, Blank JE et al. (1996) Evaluation of the Neer system of classification of proximal humeral fractures with computerized tomographic scans and plain radiographs. J Bone Joint Surg Am 78:1371–1375
Bostrom MP (1998) Expression of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res:S116–S123
Brien H, Noftall F, Macmaster S et al. (1995) Neer’s classification system: a critical appraisal. J Trauma 38:257–260
Brommage R, Hotchkiss CE, Lees CJ et al. (1999) Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys. J Clin Endocrinol Metab 84:3757–3763
Brooks CH, Revell WJ, Heatley FW (1993) Vascularity of the humeral head after proximal humeral fractures. An anatomical cadaver study. J Bone Joint Surg Br 75:132–136
Brorson S, Bagger J, Sylvest A et al. (2002a) Improved interobserver variation after training of doctors in the Neer system. A randomised trial. J Bone Joint Surg Br 84:950–954
Brorson S, Bagger J, Sylvest A et al. (2002b) Low agreement among 24 doctors using the Neer-classification; only moderate agreement on displacement, even between specialists. Int Orthop 26:271–273
Brunner A, Honigmann P, Treumann T et al. (2009) The impact of stereo-visualisation of three-dimensional CT datasets on the inter- and intraobserver reliability of the AO/OTA and Neer classifications in the assessment of fractures of the proximal humerus. J Bone Joint Surg Br 91:766–771
Claes L, Eckert-Hubner K, Augat P (2002) The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 20:1099–1105
Claes L, Eckert-Hubner K, Augat P (2003) The fracture gap size influences the local vascularization and tissue differentiation in callus healing. Langenbecks Arch Surg 388:316–322
Codman E (1934) Fractures in relation to the subacromial bursa. In: Codman E (Hrsg) The shoulder, rupture of the supraspinatus tendon and other lesions in or about the subacromial bursa. Krieger, Malabar, S 313–331
Court-Brown CM, Garg A, Mcqueen MM (2001) The epidemiology of proximal humeral fractures. Acta Orthop Scand 72:365–371
D’elia G, Roselli G, Cavalli L et al. (2010) Severe osteoporosis: diagnosis of non-hip non-vertebral (NHNV) fractures. Clin Cases Miner Bone Metab 7:85–90
De La Garza O, Lierse W, Steiner D (1992) Anatomical study of the blood supply in the human shoulder region. Acta Anat (Basel) 145:412–415
Diederichs G, Korner J, Goldhahn J et al. (2006) Assessment of bone quality in the proximal humerus by measurement of the contralateral site: a cadaveric analyze. Arch Orthop Trauma Surg 126:93–100
Duparc F (2008) Proximal humerus arterial blood revisited. In: Boileau PW, Molè D et al. (Hrsg) Proximal humerus fractures and fractures sequelae. Sauramps Medical, Montpellier, S 31–37
Duparc F, Muller JM, Freger P (2001) Arterial blood supply of the proximal humeral epiphysis. Surg Radiol Anat 23:185–190
Edelberg JM, Reed MJ (2003) Aging and angiogenesis. Front Biosci 8:s1199–s1209
Edelson G, Safuri H, Salami J et al. (2008) Natural history of complex fractures of the proximal humerus using a three-dimensional classification system. J Shoulder Elbow Surg 17:399–409
Foruria AM, De Gracia MM, Larson DR et al. (2011) The pattern of the fracture and displacement of the fragments predict the outcome in proximal humeral fractures. J Bone Joint Surg Br 93:378–386
Gerber C, Schneeberger AG, Vinh TS (1990) The arterial vascularization of the humeral head. An anatomical study. J Bone Joint Surg Am 72:1486–1494
Glowacki J (1998) Angiogenesis in fracture repair. Clin Orthop Relat Res:S82–S89
Gumina S, Giannicola G, Albino P et al. (2011) Comparison between two classifications of humeral head fractures: Neer and AO-ASIF. Acta Orthop Belg 77:751–757
Grechenig W, Pichler W, Weiglein A (2008) Frakturen des proximalen Humerus. Mögliche Ursachen von Fehlschlägen bei Osteosynthesen. Trauma Berufskrankh 10 (Suppl 1): 53-8
Habermeyer P, Schweiberer L (1989) Fractures of the proximal humerus. Orthopade 18:200–207
Hardeman F, Bollars P, Donnelly M et al. (2012) Predictive factors for functional outcome and failure in angular stable osteosynthesis of the proximal humerus. Injury 43:153–158
Hee HT, Wong HP, Low YP et al. (2001) Predictors of outcome of floating knee injuries in adults: 89 patients followed for 2-12 years. Acta Orthop Scand 72:385–394
Hepp P, Theopold J, Osterhoff G et al. (2009) Bone quality measured by the radiogrammetric parameter „cortical index“ and reoperations after locking plate osteosynthesis in patients sustaining proximal humerus fractures. Arch Orthop Trauma Surg 129:1251–1259
Hertel R (2005) Fractures of the proximal humerus in osteoporotic bone. Osteoporos Int 16 (Suppl 2):S65–S72
Hertel R, Hempfing A, Stiehler M et al. (2004) Predictors of humeral head ischemia after intracapsular fracture of the proximal humerus. J Shoulder Elbow Surg 13:427–433
Hettrich CM, Boraiah S, Dyke JP et al. (2010) Quantitative assessment of the vascularity of the proximal part of the humerus. J Bone Joint Surg Am 92:943–948
Hirzinger C, Tauber M, Resch H (2011) Proximal humerus fracture: new aspects in epidemiology, fracture morphology, and diagnostics. Unfallchirurg 114:1051–1058
Jones DB, Nolte H, Scholubbers JG et al. (1991) Biochemical signal transduction of mechanical strain in osteoblast-like cells. Biomaterials 12:101–110
Joyce ME, Roberts AB, Sporn MB et al. (1990) Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110:2195–2207
Kannus P, Palvanen M, Niemi S et al. (2009) Rate of proximal humeral fractures in older Finnish women between 1970 and 2007. Bone 44:656–659
Kirchen ME, O’connor KM, Gruber HE et al. (1995) Effects of microgravity on bone healing in a rat fibular osteotomy model. Clin Orthop Relat Res:231–242
Kralinger F, Unger S, Wambacher M et al. (2009) The medial periosteal hinge, a key structure in fractures of the proximal humerus: a biomechanical cadaver study of its mechanical properties. J Bone Joint Surg Br 91:973–976
Krappinger D, Roth T, Gschwentner M et al. (2012) Preoperative assessment of the cancellous bone mineral density of the proximal humerus using CT data. Skeletal Radiol 41:299–304
Kristiansen B, Andersen UL, Olsen CA et al. (1988) The Neer classification of fractures of the proximal humerus. An assessment of interobserver variation. Skeletal Radiol 17:420–422
Kuiper JW, Van Kuijk C, Grashuis JL et al. (1996) Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro. Osteoporos Int 6:25–30
Laing PG (1956) The arterial supply of the adult humerus. J Bone Joint Surg Am 38:1105–1116
Lill H, Hepp P, Gowin W et al. (2002) Age- and gender-related distribution of bone mineral density and mechanical properties of the proximal humerus. Rofo 174:1544–1550
Lill H, Hepp P, Korner J et al. (2003) Proximal humeral fractures: how stiff should an implant be? A comparative mechanical study with new implants in human specimens. Arch Orthop Trauma Surg 123:74–81
Mahadeva D, Dias RG, Deshpande SV et al. (2011) The reliability and reproducibility of the Neer classification system--digital radiography (PACS) improves agreement. Injury 42:339–342
Majed A, Macleod I, Bull AM et al. (2011) Proximal humeral fracture classification systems revisited. J Shoulder Elbow Surg 20:1125–1132
Menck J, Dobler A, Dohler JR (1997) Vascularization of the humerus. Langenbecks Arch Chir 382:123–127
Meyer C, Alt V, Hassanin H et al. (2005) The arteries of the humeral head and their relevance in fracture treatment. Surg Radiol Anat 27:232–237
Meyer RA, Jr., Meyer MH, Tenholder M et al. (2003) Gene expression in older rats with delayed union of femoral fractures. J Bone Joint Surg Am 85-A(7):1243–1254
Midura RJ, Su X, Morcuende JA et al. (2003) Parathyroid hormone rapidly stimulates hyaluronan synthesis by periosteal osteoblasts in the tibial diaphysis of the growing rat. J Biol Chem 278:51462–51468
Mizumoto Y, Moseley T, Drews M et al. (2003) Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7. J Bone Joint Surg Am 85-A (Suppl 3):124–130
Müller ME, Nazarian SK, Koch P, Schatzker, J (Hrsg) (1990) The comprehensive classification of fractures of long bones. Springer, Berlin
Neer CS, 2nd (1970) Displaced proximal humeral fractures. I. Classification and evaluation. J Bone Joint Surg Am 52:1077–1089
Nieminen S, Nurmi M, Satokari K (1981) Healing of femoral neck fractures; influence of fracture reduction and age. Ann Chir Gynaecol 70:26–31
Olschewski E, Murray P, Buckley R et al. (2001) Assessment of osteoporosis using standard radiographs of the wrist. J Trauma 51:912–916
Osterhoff G, Diederichs G, Tami A et al. (2012) Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures. Arch Orthop Trauma Surg 132:509–515
Palvanen M, Kannus P, Niemi S et al. (2006) Update in the epidemiology of proximal humeral fractures. Clin Orthop Relat Res 442:87–92
Reddi AH (2001) Bone morphogenetic proteins: from basic science to clinical applications. J Bone Joint Surg Am 83-A (Suppl 1):S1–S6
Reed MJ, Edelberg JM (2004) Impaired angiogenesis in the aged. Sci Aging Knowledge Environ 2004:pe7
Rhinelander FW (1979) Vascular proliferation and blood supply during fracture healing. In: Brooker AF, Edwards CC (Hrsg) External fixation: the current state of the art. Williams & Wilkins, Baltimore
Sciadini MF, Dawson JM, Banit D et al. (2000) Growth factor modulation of distraction osteogenesis in a segmental defect model. Clin Orthop Relat Res:266–277
Seebeck J, Goldhahn J, Stadele H et al. (2004) Effect of cortical thickness and cancellous bone density on the holding strength of internal fixator screws. J Orthop Res 22:1237–1242
Sidor ML, Zuckerman JD, Lyon T et al. (1993) The Neer classification system for proximal humeral fractures. An assessment of interobserver reliability and intraobserver reproducibility. J Bone Joint Surg Am 75:1745–1750
Siebenrock KA, Gerber C (1993) The reproducibility of classification of fractures of the proximal end of the humerus. J Bone Joint Surg Am 75:1751–1755
Sjoden GO, Movin T, Guntner P et al. (1997) Poor reproducibility of classification of proximal humeral fractures. Additional CT of minor value. Acta Orthop Scand 68:239–242
Sjoden GO, Movin T, Aspelin P et al. (1999) 3-D-radiographic analysis does not improve the Neer and AO classifications of proximal humeral fractures. Acta Orthop Scand 70:325–328
Solberg BD, Moon CN, Franco DP et al. (2009) Locked plating of 3- and 4-part proximal humerus fractures in older patients: the effect of initial fracture pattern on outcome. J Orthop Trauma 23:113–119
Tingart MJ, Apreleva M, Von Stechow D et al. (2003a) The cortical thickness of the proximal humeral diaphysis predicts bone mineral density of the proximal humerus. J Bone Joint Surg Br 85:611–617
Tingart MJ, Bouxsein ML, Zurakowski D et al. (2003b) Three-dimensional distribution of bone density in the proximal humerus. Calcif Tissue Int 73:531–536
Wallace AL, Draper ER, Strachan RK et al. (1994) The vascular response to fracture micromovement. Clin Orthop Relat Res:281–290
Warriner AH, Patkar NM, Curtis JR et al. (2011) Which fractures are most attributable to osteoporosis? J Clin Epidemiol 64:46–53
Yudell RM, Block MS (2000) Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg 58:761–766
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Tauber, M., Resch, H. (2014). Frakturbiologie und -morphologie. In: Lill, H., Scheibel, M., Voigt, C. (eds) Die proximale Humerusfraktur. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35257-7_1
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