Abstract
Mesoporous TiO2 was synthesized solvothermally, but its XRD pattern proved little randomly arranged mesopores. Its DRS-UV-Vis spectrum showed characteristic band gap excitation just below 400 nm and oxygen to metal charge transfer close to 250 nm. It was loaded with the model drug duloxetine (DX) by wet method. Locked-in drug within the mesopores of TiO2 was confirmed by XRD, DRS-UV-Vis and FT-IR techniques. About 11% loading of drug was verified by UV-Vis spectroscopy. The study of drug release showed two stages of burst release between 0 and 12 h and beyond that slow extended release of DX occurred. The total burst release was equal to 20%, and even at the end of 40 h the total release was equal to 90%. Hence, mesoporous TiO2 was established as a viable, biocompatible DX reservoir for its controlled release. The same mesoporous TiO2 could be convenient for the release of potentially toxic drugs which require small and extended dose.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fan, J., Lei, J., Wang, L., Yu, C., Tu, B., Zhao, D.: Rapid and High-capacity Immobilization of Enzymes based on Mesoporous Silicas with Controlled Morphologies. Chem. Commun., 2140–2141 (2003)
Vogt, M., Kunath, K., Dressman, J.B.: Dissolution Enhancement of Fenofibrate by Micronization, Cogrinding and Spray-drying: Comparison with Commercial preparations. Eur. J. Pharm. Biopharm. 68, 283–288 (2008)
Shen, S.C., Ng, W.K., Chia, L., Dong, Y.C., Tan, R.B.: Stabilized Amorphous State of Ibuprofen by Co-Spray Drying with Mesoporous SBA-15 to Enhance Dissolution Properties. J. Pharm. Sci. 99, 1997–2007 (2010)
Vallet-Regí, M., Rámila, A., del Real, R.P., Pérez-Pariente, J.: A New Property of MCM-41: Drug Delivery System. Chem. Mater. 13, 308–311 (2001)
Vallet-Regí, M., Balas, F., Arcos, D.: Mesoporous Materials for Drug Delivery. Angew. Chem. Int. Ed. 46, 7548–7558 (2007)
Khan, M.A., Akhtar, M.S., Yang, O.B.: Synthesis, Characterization and Application of Sol-gel Derived Mesoporous TiO2 Nanoparticles for Dye-Sensitized Solar Cells. Sol. Energy 84, 2195–2201 (2010)
Jitputti, J., Pavasupree, S., Suzuki, Y., Yoshikawa, S.: Synthesis and Photocatalytic Activity for Water-splitting Reaction of Nanocrystalline Mesoporous Titania prepared by Hydrothermal Method. J. Solid State Chem. 180, 1743–1749 (2007)
Sawant, D.P., Justus, J., Balasubramanian, V.V., Ariga, K., Srinivasu, P., Velmathi, S., Halligudi, S.B., Vinu, A.: Heteropoly Acid Encapsulated SBA-15/TiO2 Nanocomposites and their Unusual Performance in Acid-catalysed Organic Transformations. Chem. Eur. J. 14, 3200–3212 (2008)
Weng, W., Higuchi, T., Suzuki, M., Fukuoka, T., Shimomura, T., Ono, M., Radhakrishnan, L., Wang, H.J., Suzuki, N., Oveisi, H., Yamauchi, Y.: A High-Speed Passive-Matrix Electrochromic Display using a Mesoporous TiO2 Electrode with Vertical Porosity. Angew. Chem. Int. Ed. 49, 3956–3959 (2010)
Bao, S.J., Li, C.M., Zang, J.F., Cui, X.Q., Qiao, Y., Guo, J.: New Nanostructured TiO2 for Direct Electrochemistry and Glucose Sensor Applications. Adv. Funct. Mater. 18, 591–599 (2008)
Kondo, J.N., Yamashita, T., Nakajima, K., Lu, D., Hara, M., Domen, K.: Preparation and Crystallization Characteristics of Mesoporous TiO2 and Mixed Oxides. J. Mater. Chem. 15, 2035–2040 (2005)
Heredia-Cervera, B.E., González-Azcorra, S.A., Rodríguez-Gattorno, G., López, T., Ortiz-Islas, E., Oskam, G.: Controlled Release of Phenytoin from Nanostructured TiO2 Reservoirs. Sci. Adv. Mater. 1, 63–68 (2009)
Song, Y.Y., Schmidt-Stein, F., Bauer, S., Schmuki, P.: Amphiphilic TiO2 Nanotube Arrays: An Actively Controllable Drug Delivery System. J. Am. Chem. Soc. 131, 4230–4232 (2009)
Chao, C.S., Liu, K.H., Tung, W.-L., Chen, S.-Y., Liu, D.-M., Chang, Y.-P.: Bioactive TiO2 Ultrathin Film with Worm-like Mesoporosity for Controlled Drug Delivery. Micropor. Mesopor. Mater. 152, 58–63 (2012)
Ayon, A.A., Cantu, M., Chava, K., Agrawal, C.M., Feldman, M.D., Johnson, D., Patel, D., Marton, D., Shi, E.: Drug Loading of Nanoporous TiO2 Films. Biomed. Mater. 1, L11–L15 (2006)
Wu, K.C.-W., Yamauchi, Y., Hong, C.-Y., Yang, Y.-H., Liang, Y.-H., Funatsu, T., Tsunoda, M.: Biocompatible, Surface Functionalized Mesoporous Titania Nanoparticles for Intracellular Imaging and Anticancer Drug Delivery. Chem. Commun. 47, 5232–5234 (2011)
Han, C.-M., Lee, E.-J., Kim, H.-E., Koh, Y.-H., Jang, J.-H.: Porous TiO2 Films on Ti Implants for Controlled Release of Tetracycline-Hydrochloride (TCH). Thin Solid Films 519, 8074–8076 (2011)
Yang, H., Zhu, S., Pan, N.: Studying the Mechanisms of Titanium Dioxide as Ultraviolet-blocking Additive for Films and Fabrics by an Improved scheme. J. Korean Phys. Soc. 49, S675–S679 (2006)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ganesh, M., Hemalatha, P., Peng, M.M., Cha, W.S., Palanichamy, M., Jang, H.T. (2012). Drug Release Evaluation of Mesoporous TiO2: A Nano Carrier for Duloxetine. In: Kim, Th., Ramos, C., Abawajy, J., Kang, BH., Ślęzak, D., Adeli, H. (eds) Computer Applications for Modeling, Simulation, and Automobile. MAS ASNT 2012 2012. Communications in Computer and Information Science, vol 341. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35248-5_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-35248-5_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35247-8
Online ISBN: 978-3-642-35248-5
eBook Packages: Computer ScienceComputer Science (R0)