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Cerebral Oximetry in Cerebral Resuscitation After Cardiac Arrest

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Annual Update in Intensive Care and Emergency Medicine 2013

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

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Abstract

Interestingly, despite great medical progress over the past 50 years, survival from cardiac arrest has improved only slightly [1, 2] and long-term neurological, cognitive and functional deficits are common [3]. Pathophysiologically, cardiac arrest represents a state of generalized whole-body ischemia resulting from either a noflow or a low-flow state that culminates in inadequate organ perfusion and oxygen delivery (DO2) leading to cellular damage and death [1]. On-going inflammatory responses and cellular damage continue even after return of spontaneous circulation (ROSC), and are confounded by the problem of ischemia-reperfusion injury [1]. As a result of this unique pathological state, first termed “post resuscitation disease” in 1972 [4], even though spontaneous circulation may initially be restored in up to 50 %, many of the early survivors die in the subsequent hours to days because of a combination of neurological dysfunction, cardiac dysfunction, ischemia- reperfusion injury and persistent inflammatory responses [1].

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Authors and Affiliations

  1. Resuscitation Research Group, Department of Medicine, Division of Critical Care Medicine, Stony Brook Medical Center, New York, NY, USA

    A. Ahn & S. Parnia

  2. Department of Anesthesia and Critical Care, Royal United Hospital, BA1 3NG, Bath, UK

    J. Nolan

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  1. A. Ahn
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  2. J. Nolan
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  3. S. Parnia
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Correspondence to J. Nolan .

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Editors and Affiliations

  1. Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent Prof.

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Ahn, A., Nolan, J., Parnia, S. (2013). Cerebral Oximetry in Cerebral Resuscitation After Cardiac Arrest. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2013. Annual Update in Intensive Care and Emergency Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35109-9_28

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  • DOI: https://doi.org/10.1007/978-3-642-35109-9_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35108-2

  • Online ISBN: 978-3-642-35109-9

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