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Keimzelltumoren bei Kindern und Jugendlichen

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Zusammenfassung

Bei Kindern treten Keimzelltumoren überwiegend an extragonadalen mittelliniennahen Lokalisationen wie der Steißbeinregion, dem Mediastinum und dem zentralen Nervensystem auf und umfassen eine klinisch äußerst heterogene Gruppe von Tumoren. Die altersabhängigen Unterschiede korrelieren mit einer unterschiedlichen Tumorbiologie und Prognose.

Die Labordiagnostik bei Keimzelltumoren beinhaltet die Messung der Tumormarker AFP und β-HCG. Die radiologische Schnittbilddiagnostik ist abhängig von der primären Tumorlokalisation. Die Therapie der malignen Tumoren erfolgt risikostratifiziert innerhalb kinderonkologischer Therapieoptimierungsstudien, sie ist grundsätzlich multimodal. In niedrigen Stadien kann nach kompletter Resektion auf die adjuvante Chemotherapie verzichtet werden. Hingegen dient bei fortgeschrittenen Stadien die neoadjuvante bzw. präoperative Cisplatin-haltige Kombinationschemotherapie dem Erreichen einer kompletten Tumorresektion.

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Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Klinikum Dortmund GmbH, Beurhausstraße 40, D-44137, Dortmund, Deutschland

    D.T. Schneider

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  1. Klinik und Poliklinik für Urologie, Universitätsklinikum Essen, Essen, Germany

    Herbert Rübben

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Schneider, D. (2014). Keimzelltumoren bei Kindern und Jugendlichen. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35032-0_31

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  • DOI: https://doi.org/10.1007/978-3-642-35032-0_31

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