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Systemischer Lupus erythematodes

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Pädiatrische Rheumatologie

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Zusammenfassung

Der systemische Lupus erythematodes (SLE) ist eine B-Zellvermittelte, schubweise verlaufende Autoimmunerkrankung, von der zahlreiche Organe betroffen sein können. Charakteristisch für den SLE sind Autoantikörper, die gegen Zellkernbestandteile gerichtet sind. Diese Autoantikörper verursachen direkte Schädigungen von Organen, darüber hinaus entsteht durch komplementbindende Immunkomplexe eine Vaskulitis, die sekundär Organschäden nach sich zieht. Kriterien zur Diagnose des SLE sind zuletzt 1997 in überarbeiteter Form vom American College of Rheumatology aufgestellt worden. Von herausgehobener prognostischer Bedeutung ist das Ausmaß der Beteiligung der Nieren. Unbehandelt ist die Prognose schlecht, durch immunsuppressive Therapie hat sie sich dramatisch gebessert.

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Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen

    Prof.Dr.med. N. Wagner

  2. Klinik für Pädiatrische Nieren-, Leber- und Stoffwechselerkrankungen, Medizinischen Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover

    Prof.Dr.med. D. Haffner

  3. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen

    PD.Dr.med. K. Tenbrock

  4. Feldweg 1, 15306, Seelow

    Prof.Dr.med. G. Dannecker

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  1. Prof.Dr.med. N. Wagner
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  1. Klinik für Kinder- und Jugendmedizin, RWTH Aachen, Aachen

    Norbert Wagner

  2. Pädiatrisches Zentrum, Klinikum Stuttgart, Stuttgart

    Günther Dannecker (Ehem. Ärztlicher Direktor am Olgahospital) (Ehem. Ärztlicher Direktor am Olgahospital)

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Wagner, N., Haffner, D., Tenbrock, K., Dannecker, G. (2014). Systemischer Lupus erythematodes. In: Wagner, N., Dannecker, G. (eds) Pädiatrische Rheumatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34728-3_6

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