Abstract
Calcium can be manipulated by the pharmacological disturbance of equilibria that are maintained by the cell. Such a disturbance can be permanent using the application of a calcium ionophore, such as A23187or ionomycin, to provoke an intracellular situation similar to the digital approach discussed in chapter 2 - Direct evidence - the digital approach. An even more elegant approach is to induce a transient disturbance in cardiomyocytes, the application of 20 mM caffeine leads to the opening of the internal calcium stores, namely the sarcoplasmic reticulum (SR), by opening the ryanodine receptors.
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© 2013 Springer-Verlag Berlin Heidelberg
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Kaestner, L. (2013). Manipulation of calcium. In: Calcium signalling. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34617-0_7
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DOI: https://doi.org/10.1007/978-3-642-34617-0_7
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Online ISBN: 978-3-642-34617-0
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