Abstract
Using the patch-clamp technique, two different ion channels have been characterised further in the human red blood cell (RBC) membrane. We demonstrate that the non-selective cation channel (NSC) is permeable to Ca2+ and can be activated by prostaglandin E2 (PGE2). Therefore, the physiological role of this channel could be, together with the Ca2+-activated K+ channel, the participation in the process of blood clot formation. We give also evidence that another channel in the RBC membrane, so far assumed to be a small conductance anion channel, is more likely to be a proton or a hydroxyl ion channel.
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© 2013 Springer-Verlag Berlin Heidelberg
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Kaestner, L. (2013). Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance. In: Calcium signalling. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34617-0_22
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DOI: https://doi.org/10.1007/978-3-642-34617-0_22
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-34616-3
Online ISBN: 978-3-642-34617-0
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