Abstract
Historically, the importance of calcium was discovered when experiments were performed in the presence and absence of calcium. Thus, Sidney Ringer discovered the essential role of calcium in the process that is now named excitation–contraction coupling (ECC). Ringer performed experiments with tap water and distilled water and identified the presence of calcium as a necessary requirement for ECC. This early experiments hinted that the physiologically relevant calcium concentration is rather small and is in the µM range.
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© 2013 Springer-Verlag Berlin Heidelberg
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Kaestner, L. (2013). Direct evidence - the digital approach. In: Calcium signalling. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34617-0_2
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DOI: https://doi.org/10.1007/978-3-642-34617-0_2
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Online ISBN: 978-3-642-34617-0
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