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Imaging Epilepsy and Epileptic Seizures Using fMRI

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Abstract

Magnetic resonance imaging (MRI) has had an extraordinary impact on the diagnosis and management of epilepsy. The routine use of high-field MRI in clinical epilepsy has also encouraged interest in the potential for functional MRI (fMRI) to image the abnormal brain function that underlies epilepsy. Here, we give a brief overview of epilepsy and the current state of fMRI for the difficult problem of imaging epilepsy and epileptic seizures.

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References

  • Abreu P, Ribeiro M et al (2005) Writing epilepsy: a neurophysiological, neuropsychological and neuroimaging study. Epilepsy Behav 6(3):463–466

    Article  PubMed  Google Scholar 

  • Adelson PD, Nemoto E et al (1999) Noninvasive continuous monitoring of cerebral oxygenation periictally using near infrared spectroscopy: a preliminary report. Epilepsia 40:1484, Äì1489

    Article  CAS  PubMed  Google Scholar 

  • Aghakhani Y, Bagshaw AP et al (2004) FMRI activation during spike and wave discharges in idiopathic generalized epilepsy. Brain 127(Pt 5):1127–1144

    Article  CAS  PubMed  Google Scholar 

  • Archer JS, Briellman RS et al (2003a) Benign epilepsy with centro-temporal spikes: spike triggered fMRI shows somato-sensory cortex activity. Epilepsia 44(2):200–204

    Article  PubMed  Google Scholar 

  • Archer JS, Briellmann RS et al (2003b) Spike-triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory area. Neurology 60(3):415–421

    Article  CAS  PubMed  Google Scholar 

  • Arthurs OJ, Boniface S (2002) How well do we understand the neural origins of the fMRI BOLD signal? Trends Neurosci 25(1):27–31

    Article  CAS  PubMed  Google Scholar 

  • Avanzini G, Franceschetti S (2003) Cellular biology of epileptogenesis. Lancet Neurol 2(1):33–42

    Article  CAS  PubMed  Google Scholar 

  • Bahar S, Suh M et al (2006) Intrinsic optical signal imaging of neocortical seizures: the ’epileptic dip’. Neuroreport 17(5):499–503

    Article  PubMed  Google Scholar 

  • Baumgartner C, Serles W et al (1998) Preictal SPECT in temporal lobe epilepsy: regional cerebral blood flow is increased prior to electroencephalography-seizure onset. J Nucl Med 39(6):978–982

    CAS  PubMed  Google Scholar 

  • Blumenfeld H (2005) Cellular and network mechanisms of spike-wave seizures. Epilepsia 46(Suppl 9):21–33

    Article  CAS  PubMed  Google Scholar 

  • Boor R, Jacobs J et al (2007) Combined spike-related functional MRI and multiple source analysis in the non-invasive spike localization of benign rolandic epilepsy. Clin Neurophysiol 118(4):901–909

    Article  CAS  PubMed  Google Scholar 

  • Buchheim K, Obrig H et al (2004) Decrease in haemoglobin oxygenation during absence seizures in adult humans. Neurosci Lett 354(2):119–122

    Article  CAS  PubMed  Google Scholar 

  • Buzsaki G (1991) The thalamic clock: emergent network properties. Neuroscience 41(2–3):351–364

    Article  CAS  PubMed  Google Scholar 

  • Carmichael DW, Hamandi K et al (2008) An investigation of the relationship between BOLD and perfusion signal changes during epileptic generalised spike wave activity. Magn Reson Imaging 26(7):870–873

    Article  PubMed  Google Scholar 

  • De Simone R, Silvestrini M et al (1998) Changes in cerebral blood flow velocities during childhood absence seizures. Pediatr Neurol 18:132, Äì135

    Article  PubMed  Google Scholar 

  • Detre JA, Zhang W et al (1994) Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed 7(1–2):75–82

    Article  CAS  PubMed  Google Scholar 

  • Detre JA, Sirven JI et al (1995) Localization of subclinical ictal activity by functional magnetic resonance imaging: correlation with invasive monitoring. Ann Neurol 38(4):618–624

    Article  CAS  PubMed  Google Scholar 

  • Di Bonaventura C, Carnfi M et al (2006) Ictal hemodynamic changes in late-onset rasmussen encephalitis. Ann Neurol 59(2):432–433

    Article  PubMed  Google Scholar 

  • Diehl B, Knecht S et al (1998) Cerebral hemodynamic response to generalized spike-wave discharges. Epilepsia 39:1284, Äì1289

    Article  CAS  PubMed  Google Scholar 

  • Dymond AM, Crandall PH (1976) Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man. Brain Res 102(1):191–196

    Article  CAS  PubMed  Google Scholar 

  • Elger CE, Lehnertz K (1998) Seizure prediction by non-linear time series analysis of brain electrical activity. Eur J Neurosci 10(2):786–789

    Article  CAS  PubMed  Google Scholar 

  • Espay AJ, Schmithorst VJ et al (2008) Chronic isolated hemifacial spasm as a manifestation of epilepsia partialis continua. Epilepsy Behav 12(2):332–336

    Article  PubMed  Google Scholar 

  • Federico P, Abbott DF et al (2005) Functional MRI of the pre-ictal state. Brain 128(Pt 8):1811–1817

    Article  PubMed  Google Scholar 

  • Folbergrová J, Ingvar M et al (1981) Metabolic changes in cerebral cortex, hippocampus, and cerebellum during sustained bicuculline-induced seizures. J Neurochem 37(5):1228–1238

    Article  PubMed  Google Scholar 

  • Frostig RD, Lieke EE et al (1990) Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc Natl Acad Sci U S A 87(16):6082–6086

    Article  CAS  PubMed  Google Scholar 

  • Garraux G, Hallett M et al (2005) CASL fMRI of subcortico-cortical perfusion changes during memory-guided finger sequences. Neuroimage 25(1):122–132

    Article  PubMed  Google Scholar 

  • Gloor P (1968) (ADD)

    Google Scholar 

  • Gotman J (2008) Epileptic networks studied with EEG-fMRI. Epilepsia 49(Suppl 3):42–51

    Article  PubMed  Google Scholar 

  • Gotman J, Grova C et al (2005) Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci U S A 102(42):15236–15240

    Article  CAS  PubMed  Google Scholar 

  • Greicius MD, Krasnow B et al (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 100(1):253–258

    Article  CAS  PubMed  Google Scholar 

  • Hamandi K et al (2006) EEG-fMRI of idiopathic and secondarily generalized epilepsies. Neuroimage 31(4):1700–1710

    Article  PubMed  Google Scholar 

  • Hamandi K, Laufs H et al (2008) BOLD and perfusion changes during epileptic generalised spike wave activity. Neuroimage 39(2):608–618

    Article  PubMed  Google Scholar 

  • Hauser WA, Hesdorffer DC (1990) Epilepsy: frequency, causes and consequences. Demos Vermande, New York

    Google Scholar 

  • Hauser WA, Annegers JF et al (1991) Prevalence of epilepsy in Rochester, Minnesota: 1940‚Äì1980. Epilepsia 32:429, Äì445

    Article  CAS  PubMed  Google Scholar 

  • Hill RA, Chiappa KH et al (1999) Hemodynamic and metabolic aspects of photosensitive epilepsy revealed by functional magnetic resonance imaging and magnetic resonance spectroscopy. Epilepsia 40(7):912–920

    Article  CAS  PubMed  Google Scholar 

  • Hoge RD, Atkinson J et al (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A 96(16):9403–9408

    Article  CAS  PubMed  Google Scholar 

  • Hoshi Y, Tamura M (1992) Cerebral oxygenation state in chemically induced seizures in the rat‚Äîstudy by near infrared spectrophotometry. Adv Exp Med Biol 316:137, Äì142

    Article  CAS  PubMed  Google Scholar 

  • Hwang DY, Golby AJ (2006) The brain basis for episodic memory: insights from functional MRI, intracranial EEG, and patients with epilepsy. Epilepsy Behav 8(1):115–126

    Article  PubMed  Google Scholar 

  • Jackson GD, Connelly A et al (1994) Functional magnetic resonance imaging of focal seizures. Neurology 44(5):850–856

    Article  CAS  PubMed  Google Scholar 

  • Jacobs J, Hawco C et al (2008) Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy. Neuroimage 40(2):601–614

    Article  PubMed  Google Scholar 

  • Kobayashi E, Hawco CS et al (2006) Widespread and intense BOLD changes during brief focal electrographic seizures. Neurology 66(7):1049–1055

    Article  CAS  PubMed  Google Scholar 

  • Krings T, Töpper R et al (2000) Hemodynamic changes in simple partial epilepsy: a functional MRI study. Neurology 54(2):524–527

    Article  CAS  PubMed  Google Scholar 

  • Kurtzke JF (1982) The current neurologic burden of illness and injury in the United States. Neurology 32(11):1207–1214

    Article  CAS  PubMed  Google Scholar 

  • Laufs H, Duncan JS (2007) Electroencephalography/functional MRI in human epilepsy: what it currently can and cannot do. Curr Opin Neurol 20(4):417–423

    Article  PubMed  Google Scholar 

  • Laufs H, Lengler U et al (2006) Linking generalized spike-and-wave discharges and resting state brain activity by using EEG/fMRI in a patient with absence seizures. Epilepsia 47(2):444–448

    Article  PubMed  Google Scholar 

  • Laurienti PJ (2004) Deactivations, global signal, and the default mode of brain function. J Cogn Neurosci 16(9):1481–1483, No abstract available

    Article  PubMed  Google Scholar 

  • Lazeyras F, Blanke O et al (2000) MRI, (1) H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity. Neurology 55(11):1677–1682

    Article  CAS  PubMed  Google Scholar 

  • Leal A, Dias A et al (2006) The BOLD effect of interictal spike activity in childhood occipital lobe epilepsy. Epilepsia 47(9):1536–1542

    Article  PubMed  Google Scholar 

  • Lehnertz K, Elger CE (1995) Spatio-temporal dynamics of the primary epileptogenic area in temporal lobe epilepsy characterized by neuronal complexity loss. Electroencephalogr Clin Neurophysiol 95(2):108–117

    Article  CAS  PubMed  Google Scholar 

  • Lemieux L, Salek-Haddadi A et al (2007) Modelling large motion events in fMRI studies of patients with epilepsy. Magn Reson Imaging 25(6):894–901

    Article  PubMed  Google Scholar 

  • Lengler U, Kafadar I et al (2007) FMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood. A simultaneous EEG-functional MRI study. Epilepsy Res 75(1):29–38

    Article  PubMed  Google Scholar 

  • Litt B, Esteller R et al (2001) Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Neuron 30(1):51–64

    Article  CAS  PubMed  Google Scholar 

  • Logothetis NK, Pauls J et al (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412(6843):150–157

    Article  CAS  PubMed  Google Scholar 

  • Makiranta M, Ruohonen J et al (2005) BOLD signal increase preceeds EEG spike activity‚Äìa dynamic penicillin induced focal epilepsy in deep anesthesia. Neuroimage 27:715, Äì724

    Article  PubMed  Google Scholar 

  • Mazoyer B, Zago L et al (2001) Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull 54(3):287–298

    Article  CAS  PubMed  Google Scholar 

  • McCormick DA, Contreras D (2001) On the cellular and network bases of epileptic seizures. Annu Rev Physiol 63:815–846

    Article  CAS  PubMed  Google Scholar 

  • Meeren H, van Luijtelaar G et al (2005) Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory. Arch Neurol 62(3):371–376

    Article  PubMed  Google Scholar 

  • Moeller F et al (2008) Changes in activity of striato-thalamo-cortical network precede generalized spike wave ­discharges. Neuroimage 39(4):1839–1849

    Article  PubMed  Google Scholar 

  • Mórocz IA, Karni A et al (2003) fMRI of triggerable aurae in musicogenic epilepsy. Neurology 60(4):705–709

    Article  PubMed  Google Scholar 

  • Neuroimaging Subcommission of the ILAE (2000) Commission on diagnostic strategies recommendations for functional neuroimaging of persons with epilepsy. Epilepsia 41(10):1350–1356

    Article  Google Scholar 

  • Penfield W (1933) [ADD]

    Google Scholar 

  • Penfield W (1954) (ADD)

    Google Scholar 

  • Polack PO, Guillemain I et al (2007) Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci 27(24):6590–6599

    Article  CAS  PubMed  Google Scholar 

  • Raichle ME (2003) Functional brain imaging and human brain function. J Neurosci 23(10):3959–3962

    CAS  PubMed  Google Scholar 

  • Raichle ME, MacLeod AM et al (2001) A default mode of brain function. Proc Natl Acad Sci U S A 98(2):676–682

    Article  CAS  PubMed  Google Scholar 

  • Salek-Haddadi A, Merschhemke M et al (2002) Simultaneous EEG-correlated ictal fMRI. Neuroimage 16(1):32–40

    Article  PubMed  Google Scholar 

  • Sander JW (2003) The epidemiology of epilepsy revisited. Curr Opin Neurol 16:165–170

    Article  PubMed  Google Scholar 

  • Schwartz TH (2007) Neurovascular coupling and epilepsy: hemodynamic markers for localizing and ­predicting seizure onset. Epilepsy Curr 7(4):91–94

    Article  PubMed  Google Scholar 

  • Shariff S, Suh M et al (2006) Recent developments in oximetry and perfusion-based mapping techniques and their role in the surgical treatment of neocortical epilepsy. Epilepsy Behav 8(2):363–375

    Article  PubMed  Google Scholar 

  • Spencer SS (2002) Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia 43(3):219–227

    Article  PubMed  Google Scholar 

  • Sperling MR, Skolnick BE (1995) Cerebral blood flow during spike-wave discharges. Epilepsia 36(2):156–163

    Article  CAS  PubMed  Google Scholar 

  • Stefanovic B, Warnking JM et al (2005) Hemodynamic and metabolic responses to activation, deactivation and epileptic discharges. Neuroimage 28(1):205–215

    Article  PubMed  Google Scholar 

  • Suh M, Bahar S et al (2006a) Blood volume and hemoglobin oxygenation response following elec-trical stimulation of human cortex. Neuroimage 31(1):66–75

    Article  PubMed  Google Scholar 

  • Suh M, Ma H et al (2006b) Neurovascular coupling and oximetry during epileptic events. Mol Neurobiol 33(3):181–197

    Article  CAS  PubMed  Google Scholar 

  • Sutherling WW, Hershman LM et al (1980) Seizures induced by playing music. Neurology 30(9):1001–1004

    Article  CAS  PubMed  Google Scholar 

  • Swanson SJ, Sabsevitz DS et al (2007) Functional magnetic resonance imaging of language in epilepsy. Neuropsychol Rev 17(4):491–504

    Article  PubMed  Google Scholar 

  • Tenney JR, Marshall PC et al (2004) FMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. Epilepsia 45(10):1240–1247

    Article  PubMed  Google Scholar 

  • Weinand ME, Carter LP et al (1994) Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy. Neurosurgery 35:657, Äì664

    Article  CAS  PubMed  Google Scholar 

  • Weinand ME, Carter LP et al (1997) Cerebral blood flow and temporal lobe epileptogenicity. J Neurosurg 86(2):226–232

    Article  CAS  PubMed  Google Scholar 

  • Wiebe S, Blume WT et al (2001) A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med 345:311–318

    Article  CAS  PubMed  Google Scholar 

  • Wolf RL, Alsop DC et al (2001) Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol 22(7):1334–1341

    CAS  PubMed  Google Scholar 

  • Wu R, Bruening R et al (1999) MR measurement of regional relative cerebral blood volume in epilepsy. J Magn Reson Imaging 9:435–440

    Article  CAS  PubMed  Google Scholar 

  • Yeo DT, Fessler JA et al (2008) Motion robust magnetic susceptibility and field inhomogeneity estimation using regularized image restoration techniques for fMRI. Med Image Comput Comput Assist Interv 11(Pt 1):991–998

    PubMed  Google Scholar 

  • Zyss J, Xie-Brustolin J et al (2007) Epilepsia partialis continua with dystonic hand movement in a patient with a malformation of cortical development. Mov Disord 22(12):1793–1796

    Article  PubMed  Google Scholar 

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Correspondence to Simon M. Glynn .

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Glynn, S.M., Detre, J.A. (2013). Imaging Epilepsy and Epileptic Seizures Using fMRI. In: Ulmer, S., Jansen, O. (eds) fMRI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34342-1_14

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