Skip to main content
SpringerLink
Log in

Genetic Background of Implant Failure

  • Chapter
  • First Online:
Oral and Cranial Implants

Abstract

Contemporary dental implant therapy enjoys the highly predictable outcome of osseointegration, rapidly establishing the intimate connection between bone tissue and the surface of the endosseous implant fixture. Osseointegration can occur with an implant surface exhibiting various surface chemistries: i.e. commercially pure titanium, titanium alloys or crystalline/amorphous calcium phosphate and surface structures with isotropic turned or anisotropic micro- to nano-topography (Attard and Zarb 2005; Balshe et al. 2009; Cooper 2000; Mendonca et al. 2008; Stanford 2007). From a number of clinical outcome studies, an osseointegration-based implant is considered a safe and efficient treatment option in dentistry.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alvim-Pereira F, Montes CC, Thome G, Olandoski M, Trevilatto PC (2008) Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss. Clin Oral Implants Res 19(8):786–795

    Article  PubMed  Google Scholar 

  • Arend WP, Guthridge CJ (2000) Biological role of interleukin 1 receptor antagonist isoforms. Ann Rheum Dis 59(Suppl 1):i60–i64

    Article  PubMed  Google Scholar 

  • Arisan V, Karabuda C, Özdemir T (2005) Effect of MMP-1 polymorphism on early term osseointegrated dental implant failure: a pilot study. J Cell Mol Biol 4:53–58

    Google Scholar 

  • Attard NJ, Zarb GA (2005) Immediate and early implant loading protocols: a literature review of clinical studies. J Prosthet Dent 94(3):242–258

    Article  PubMed  Google Scholar 

  • Balshe AA, Assad DA, Eckert SE, Koka S, Weaver AL (2009) A retrospective study of the survival of smooth- and rough-surface dental implants. Int J Oral Maxillofac Implants 24(6):1113–1118

    PubMed  Google Scholar 

  • Boraas JC, Messer LB, Till MJ (1988) A genetic contribution to dental caries, occlusion, and morphology as demonstrated by twins reared apart. J Dent Res 67(9):1150–1155

    Article  PubMed  Google Scholar 

  • Bormann KH, Stuhmer C, Z’Graggen M, Kokemoller H, Rucker M, Gellrich NC (2010) IL-1 polymorphism and periimplantitis. A literature review. Schweiz Monatsschr Zahnmed 120(6):510–520

    PubMed  Google Scholar 

  • Bowen WH, Koo H (2011) Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms. Caries Res 45(1):69–86

    Article  PubMed  Google Scholar 

  • Bretz WA, Corby PM, Hart TC, Costa S, Coelho MQ, Weyant RJ et al (2005a) Dental caries and microbial acid production in twins. Caries Res 39(3):168–172

    Article  PubMed  Google Scholar 

  • Bretz WA, Corby PM, Schork NJ, Robinson MT, Coelho M, Costa S et al (2005b) Longitudinal analysis of heritability for dental caries traits. J Dent Res 84(11):1047–1051

    Article  PubMed  Google Scholar 

  • Campos MI, dos Santos MC, Trevilatto PC, Scarel-Caminaga RM, Bezerra FJ, Line SR (2004) Early failure of dental implants and TNF-alpha (G-308A) gene polymorphism. Implant Dent 13(1):95–101

    Article  PubMed  Google Scholar 

  • Campos MI, Godoy dos Santos MC, Trevilatto PC, Scarel-Caminaga RM, Bezerra FJ, Line SR (2005a) Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants. Implant Dent 14(4):391–396

    PubMed  Google Scholar 

  • Campos MI, Santos MC, Trevilatto PC, Scarel-Caminaga RM, Bezerra FJ, Line SR (2005b) Evaluation of the relationship between interleukin-1 gene cluster polymorphisms and early implant failure in non-smoking patients. Clin Oral Implants Res 16(2):194–201

    Article  PubMed  Google Scholar 

  • Chaudhari AU, Byakod GN, Waghmare PF, Karhadkar VM (2011) Correlation of levels of interleukin-1beta in gingival crevicular fluid to the clinical parameters of chronic periodontitis. J Contemp Dent Pract 12(1):52–59

    Article  PubMed  Google Scholar 

  • Chaudhary AK, Pandya S, Mehrotra R, Bharti AC, Jain S, Singh M (2010) Functional polymorphism of the MMP-1 promoter (-1607 1 G/2G) in potentially malignant and malignant head and neck lesions in an Indian population. Biomarkers 15(8):684–692

    Article  PubMed  Google Scholar 

  • Chuang SK (2005) Jawbone quality, jaw shape, implant length, and overdenture treatment protocol were associated with implant failures. J Evid Based Dent Pract 5(4):215–216

    Article  PubMed  Google Scholar 

  • Chuang SK, Tian L, Wei LJ, Dodson TB (2002a) Predicting dental implant survival by use of the marginal approach of the semi-parametric survival methods for clustered observations. J Dent Res 81(12):851–855

    Article  PubMed  Google Scholar 

  • Chuang SK, Wei LJ, Douglass CW, Dodson TB (2002b) Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res 81(8):572–577

    Article  PubMed  Google Scholar 

  • Conry JP, Messer LB, Boraas JC, Aeppli DP, Bouchard TJ Jr (1993) Dental caries and treatment characteristics in human twins reared apart. Arch Oral Biol 38(11):937–943

    Article  PubMed  Google Scholar 

  • Cooper LF (2000) A role for surface topography in creating and maintaining bone at titanium endosseous implants. J Prosthet Dent 84(5):522–534

    Article  PubMed  Google Scholar 

  • Curtis DA, Kao R, Plesh O, Finzen F, Franz L (1997) Crevicular fluid analysis around two failing dental implants: a clinical report. J Prosthodont 6(3):210–214

    Article  PubMed  Google Scholar 

  • Cury PR, Horewicz VV, Ferrari DS, Brito R Jr, Sendyk WR, Duarte PM et al (2009) Evaluation of the effect of tumor necrosis factor-alpha gene polymorphism on the risk of peri-implantitis: a case–control study. Int J Oral Maxillofac Implants 24(6):1101–1105

    PubMed  Google Scholar 

  • De Boever AL, De Boever JA (2006) Early colonization of non-submerged dental implants in patients with a history of advanced aggressive periodontitis. Clin Oral Implants Res 17(1):8–17

    Article  PubMed  Google Scholar 

  • de Souza AP, Trevilatto PC, Scarel-Caminaga RM, Brito RB, Line SR (2003) MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population. J Clin Periodontol 30(2):154–158

    Article  PubMed  Google Scholar 

  • Dirschnabel AJ, Alvim-Pereira F, Alvim-Pereira CC, Bernardino JF, Rosa EA, Trevilatto PC (2011) Analysis of the association of IL1B(C-511 T) polymorphism with dental implant loss and the clusterization phenomenon. Clin Oral Implants Res 22(11):1235–1241

    Article  PubMed  Google Scholar 

  • Dos Santos MC, Campos MI, Souza AP, Scarel-Caminaga RM, Mazzonetto R, Line SR (2004) Analysis of the transforming growth factor-beta 1 gene promoter polymorphisms in early osseointegrated implant failure. Implant Dent 13(3):262–269

    Article  PubMed  Google Scholar 

  • Eckert SE, Wollan PC (1998) Retrospective review of 1170 endosseous implants placed in partially edentulous jaws. J Prosthet Dent 79(4):415–421

    Article  PubMed  Google Scholar 

  • Esposito M, Hirsch JM, Lekholm U, Thomsen P (1998) Biological factors contributing to failures of osseointegrated oral implants (I) Success criteria and epidemiology. Eur J Oral Sci 106(1):527–551

    Article  PubMed  Google Scholar 

  • Fairpo CG (1979) Total caries experience in monozygotic and like-sexed dizygotic twins of caucasoid origin aged 5 to 15 years. Arch Oral Biol 24(7):491–494

    Article  PubMed  Google Scholar 

  • Feloutzis A, Lang NP, Tonetti MS, Burgin W, Bragger U, Buser D et al (2003) IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population. Clin Oral Implants Res 14(1):10–17

    Article  PubMed  Google Scholar 

  • Friberg B, Nilson H, Olsson M, Palmquist C (1997) Mk II: the self-tapping Branemark implant: 5-year results of a prospective 3-center study. Clin Oral Implants Res 8(4):279–285

    Article  PubMed  Google Scholar 

  • Gruica B, Wang HY, Lang NP, Buser D (2004) Impact of IL-1 genotype and smoking status on the prognosis of osseointegrated implants. Clin Oral Implants Res 15(4):393–400

    Article  PubMed  Google Scholar 

  • Hardt CR, Grondahl K, Lekholm U, Wennstrom JL (2002) Outcome of implant therapy in relation to experienced loss of periodontal bone support: a retrospective 5- year study. Clin Oral Implants Res 13(5):488–494

    Article  PubMed  Google Scholar 

  • Honig J, Rordorf-Adam C, Siegmund C, Wiedemann W, Erard F (1989) Increased interleukin-1 beta (IL-1 beta) concentration in gingival tissue from periodontitis patients. J Periodontal Res 24(6):362–367

    Article  PubMed  Google Scholar 

  • Jaffin RA, Berman CL (1991) The excessive loss of Branemark fixtures in type IV bone: a 5-year analysis. J Periodontol 62(1):2–4

    Article  PubMed  Google Scholar 

  • Jahangiri L, Devlin H, Ting K, Nishimura I (1998) Current perspectives in residual ridge remodeling and its ­clinical implications: a review. J Prosthet Dent 80(2):224–237

    Article  PubMed  Google Scholar 

  • Jansson H, Hamberg K, De Bruyn H, Bratthall G (2005) Clinical consequences of IL-1 genotype on early implant failures in patients under periodontal maintenance. Clin Implant Dent Relat Res 7(1):51–59

    Article  PubMed  Google Scholar 

  • Jemt T, Hager P (2006) Early complete failures of fixed implant-supported prostheses in the edentulous maxilla: a 3-year analysis of 17 consecutive cluster failure patients. Clin Implant Dent Relat Res 8(2):77–86

    Article  PubMed  Google Scholar 

  • Kao RT, Curtis DA, Richards DW, Preble J (1995) Increased interleukin-1 beta in the crevicular fluid of diseased implants. Int J Oral Maxillofac Implants 10(6):696–701

    PubMed  Google Scholar 

  • Karoussis IK, Salvi GE, Heitz-Mayfield LJ, Bragger U, Hammerle CH, Lang NP (2003) Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res 14(3):329–339

    Article  PubMed  Google Scholar 

  • Kelly J, Lin A, Wang CJ, Park S, Nishimura I (2009) Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model. J Prosthodont 18(6):473–478

    Article  PubMed  Google Scholar 

  • Kingsmill VJ (1999) Post-extraction remodeling of the adult mandible. Crit Rev Oral Biol Med 10(3):384–404

    Article  PubMed  Google Scholar 

  • Kleinberg I (2002) A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. Crit Rev Oral Biol Med 13(2):108–125

    Article  PubMed  Google Scholar 

  • Klokkevold PR, Han TJ (2007) How do smoking, diabetes, and periodontitis affect outcomes of implant treatment? Int J Oral Maxillofac Implants 22(Suppl):173–202

    PubMed  Google Scholar 

  • Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW et al (1997) The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 24(1):72–77

    Article  PubMed  Google Scholar 

  • Krasse B (2001) The Vipeholm Dental Caries Study: recollections and reflections 50 years later. J Dent Res 80(9):1785–1788

    Article  PubMed  Google Scholar 

  • Laine ML, Leonhardt A, Roos-Jansaker AM, Pena AS, van Winkelhoff AJ, Winkel EG et al (2006) IL-1RN gene polymorphism is associated with peri-­implantitis. Clin Oral Implants Res 17(4):380–385

    Article  PubMed  Google Scholar 

  • Laine ML, Crielaard W, Loos BG (2012) Genetic susceptibility to periodontitis. Periodontol 2000 58(1):37–68

    Article  PubMed  Google Scholar 

  • Leite MF, Santos MC, de Souza AP, Line SR (2008) Osseointegrated implant failure associated with MMP-1 promoter polymorphisms (-1607 and -519). Int J Oral Maxillofac Implants 23(4):653–658

    PubMed  Google Scholar 

  • Lekholm U (2003) Immediate/early loading of oral implants in compromised patients. Periodontol 2000 2000(33):194–203

    Article  Google Scholar 

  • Lekholm U, Zarb GA (1985) Patient selection and preparation. In: Branemark PI, Zarb GA, Alberktsson T (eds) Tissue-integrated prostheses: osseointegration in clinical dentistry. Quintessense Publishing Co, Chicago, pp 199–209

    Google Scholar 

  • Levin L, Ofec R, Grossmann Y, Anner R (2011) Periodontal disease as a risk for dental implant failure over time: a long-term historical cohort study. J Clin Periodontol 38(8):732–737

    Article  PubMed  Google Scholar 

  • Lin YH, Huang P, Lu X, Guan DH, Man Y, Wei N et al (2007) The relationship between IL-1 gene polymorphism and marginal bone loss around dental implants. J Oral Maxillofac Surg 65(11):2340–2344

    Article  PubMed  Google Scholar 

  • Liu CM, Hou LT, Wong MY, Rossomando EF (1996) Relationships between clinical parameters, Interleukin 1B and histopathologic findings of gingival tissue in periodontitis patients. Cytokine 8(2):161–167

    Article  PubMed  Google Scholar 

  • Liu D, Guo H, Li Y, Xu X, Yang K, Bai Y (2012) Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis. PLoS One 7(2):e31251

    Article  PubMed  Google Scholar 

  • Loo WT, Wang M, Jin LJ, Cheung MN, Li GR (2011) Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. Arch Oral Biol 56(10):1081–1090

    Article  PubMed  Google Scholar 

  • Lopez-Lopez J, Estrugo-Devesa A, Jane-Salas E, Ayuso-Montero R, Gomez-Vaquero C (2011) Early diagnosis of osteoporosis by means of orthopantomograms and oral x-rays: a systematic review. Medicina Oral Patol Oral Cir Bucal 16(7):e905–e913

    Article  Google Scholar 

  • Mansbridge JN (1959) Heredity and dental caries. J Dent Res 38(2):337–347

    Article  PubMed  Google Scholar 

  • Marie PJ, Coffin JD, Hurley MM (2005) FGF and FGFR signaling in chondrodysplasias and craniosynostosis. J Cell Biochem 96(5):888–896

    Article  PubMed  Google Scholar 

  • Martelli FS, Mengoni A, Martelli M, Rosati C, Fanti E (2011) VDR TaqI polymorphism is associated with chronic periodontitis in Italian population. Arch Oral Biol 56(12):1494–1498

    Article  PubMed  Google Scholar 

  • Melo RF, Lopes BM, Shibli JA, Marcantonio Junior E, Marcantonio RA, Galli GM (2011). Interleukin-1 beta and Interleukin-6 expression and gene polymorphisms in subjects with peri-implant disease. Clin Implant Dent Relat Res. 2011 Mar 17. doi: 10.1111/j.1708-8208.2010.00325.x. [Epub ahead of print]

  • Melville H, Wang Y, Taub PJ, Jabs EW (2010) Genetic basis of potential therapeutic strategies for craniosynostosis. Am J Med Genet A 152A(12):3007–3015

    Article  PubMed  Google Scholar 

  • Mendonca G, Mendonca DB, Aragao FJ, Cooper LF (2008) Advancing dental implant surface technology–from micron- to nanotopography. Biomaterials 29(28):3822–3835

    Article  PubMed  Google Scholar 

  • Mengatto CM, Mussano F, Honda Y, Colwell CS, Nishimura I (2011) Circadian rhythm and cartilage extracellular matrix genes in osseointegration: a genome-wide screening of implant failure by vitamin D deficiency. PLoS One 6(1):e15848

    Article  PubMed  Google Scholar 

  • Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE et al (2000) Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 71(11):1699–1707

    Article  PubMed  Google Scholar 

  • Montes CC, Alvim-Pereira F, de Castilhos BB, Sakurai ML, Olandoski M, Trevilatto PC (2009) Analysis of the association of IL1B (C  +  3954 T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population. Clin Oral Implants Res 20(2):208–217

    Article  PubMed  Google Scholar 

  • Moy PK, Medina D, Shetty V, Aghaloo TL (2005) Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants 20(4):569–577

    PubMed  Google Scholar 

  • Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ et al (2011) Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 17(10):1231–1234

    Article  PubMed  Google Scholar 

  • Nishimura I, Garrett N (2004) Impact of Human Genome Project on treatment of frail and edentulous patients. Gerodontology 21(1):3–9

    Article  PubMed  Google Scholar 

  • Nishimura I, Hosokawa R, Atwood DA (1992) The knife-edge tendency in mandibular residual ridges in women. J Prosthet Dent 67(6):820–826

    Article  PubMed  Google Scholar 

  • Ong CT, Ivanovski S, Needleman IG, Retzepi M, Moles DR, Tonetti MS et al (2008) Systematic review of implant outcomes in treated periodontitis subjects. J Clin Periodontol 35(5):438–462

    Article  PubMed  Google Scholar 

  • Paes Leme AF, Koo H, Bellato CM, Bedi G, Cury JA (2006) The role of sucrose in cariogenic dental biofilm formation–new insight. J Dent Res 85(10):878–887

    Article  PubMed  Google Scholar 

  • Page RC (1991) The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 26(3 Pt 2):230–242

    Article  PubMed  Google Scholar 

  • Panagakos FS, Aboyoussef H, Dondero R, Jandinski JJ (1996) Detection and measurement of inflammatory cytokines in implant crevicular fluid: a pilot study. Int J Oral Maxillofac Implants 11(6):794–799

    PubMed  Google Scholar 

  • Pigossi SC, Alvim-Pereira F, Montes CC, Finoti LS, Secolin R, Trevilatto PC et al (2012) Genetic association study between Interleukin 10 gene and dental implant loss. Arch Oral Biol 57(9):1256–1263

    Article  PubMed  Google Scholar 

  • Potter RH (1990) Twin half-sibs: a research design for genetic epidemiology of common dental disorders. J Dent Res 69(8):1527–1530

    Article  PubMed  Google Scholar 

  • Repeke CE, Trombone AP, Ferreira SB Jr, Cardoso CR, Silveira EM, Martins W Jr et al (2009) Strong and persistent microbial and inflammatory stimuli overcome the genetic predisposition to higher matrix metalloproteinase-1 (MMP-1) expression: a mechanistic explanation for the lack of association of MMP1-1607 single-nucleotide polymorphism genotypes with MMP-1 expression in chronic periodontitis lesions. J Clin Periodontol 36(9):726–738

    Article  PubMed  Google Scholar 

  • Rintakoski K, Kaprio J, Murtomaa H (2010) Genetic and environmental factors in oral health among twins. J Dent Res 89(7):700–704

    Article  PubMed  Google Scholar 

  • Rogers MA, Figliomeni L, Baluchova K, Tan AE, Davies G, Henry PJ et al (2002) Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants? J Periodontal Res 37(1):37–41

    Article  PubMed  Google Scholar 

  • Santos MC, Campos MI, Souza AP, Trevilatto PC, Line SR (2004) Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure. Int J Oral Maxillofac Implants 19(1):38–43

    PubMed  Google Scholar 

  • Scapoli C, Trombelli L, Mamolini E, Collins A (2005) Linkage disequilibrium analysis of case-control data: an application to generalized aggressive periodontitis. Genes Immun 6(1):44–52

    PubMed  Google Scholar 

  • Schwartz-Arad D, Laviv A, Levin L (2008) Failure causes, timing, and cluster behavior: an 8-year study of dental implants. Implant Dent 17(2):200–207

    Article  PubMed  Google Scholar 

  • Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P et al (2004) Large-scale copy number polymorphism in the human genome. Science 305(5683):525–528

    Article  PubMed  Google Scholar 

  • Sheiham A (1984) Changing trends in dental caries. Int J Epidemiol 13(2):142–147

    Article  PubMed  Google Scholar 

  • Shimpuku H, Nosaka Y, Kawamura T, Tachi Y, Shinohara M, Ohura K (2003) Genetic polymorphisms of the interleukin-1 gene and early marginal bone loss around endosseous dental implants. Clin Oral Implants Res 14(4):423–429

    Article  PubMed  Google Scholar 

  • Smith EG, Spatafora GA (2012) Gene regulation in S. mutans: complex control in a complex environment. J Dent Res 91(2):133–141

    Article  PubMed  Google Scholar 

  • Stanford CM (2007) Dental implants. A role in geriatric dentistry for the general practice? J Am Dent Assoc 138(Suppl):34S–40S

    PubMed  Google Scholar 

  • Stokes A, Drozdov I, Guerra E, Ouzounis CA, Warnakulasuriya S, Gleeson MJ et al (2011) Copy number and loss of heterozygosity detected by SNP array of formalin-fixed tissues using whole-genome amplification. PLoS One 6(9):e24503

    Article  PubMed  Google Scholar 

  • Suwanwela J, Lee J, Lin A, Ucer TC, Devlin H, Sinsheimer J, Garrett NR, Nishimura I (2011) A genetic association study of single-nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible. PLoS One 19(6):e16204

    Article  Google Scholar 

  • Tachi Y, Shimpuku H, Nosaka Y, Kawamura T, Shinohara M, Ueda M et al (2003) Vitamin D receptor gene polymorphism is associated with chronic periodontitis. Life Sci 73(26):3313–3321

    Article  PubMed  Google Scholar 

  • Tsai CC, Ho YP, Chen CC (1995) Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitis. J Periodontol 66(10):852–859

    Article  PubMed  Google Scholar 

  • Vaz P, Gallas MM, Braga AC, Sampaio-Fernandes JC, Felino A, Tavares P (2011) IL1 gene polymorphisms and unsuccessful dental implants. Clin Oral Implants Res. doi: 10.1111/j.1600-0501.2011.02322.x

  • Wang C, Zhao H, Xiao L, Xie C, Fan W, Sun S et al (2009) Association between vitamin D receptor gene polymorphisms and severe chronic periodontitis in a Chinese population. J Periodontol 80(4):603–608

    Article  PubMed  Google Scholar 

  • Wilson TG Jr, Nunn M (1999) The relationship between the interleukin-1 periodontal genotype and implant loss. Initial data. J Periodontol 70(7):724–729

    Article  PubMed  Google Scholar 

  • Winkler S, Boberick KG, Braid S, Wood R, Cari MJ (2008) Implant replacement of congenitally missing lateral incisors: a case report. J Oral Implantol 34(2):115–118

    Article  PubMed  Google Scholar 

  • Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O’Brien CA (2011) Matrix-embedded cells control osteoclast formation. Nat Med 17(10):1235–1241

    Article  PubMed  Google Scholar 

  • Zhang J, Sun X, Xiao L, Xie C, Xuan D, Luo G (2011) Gene polymorphisms and periodontitis. Periodontol 2000 56(1):102–124

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisions of Prosthodontics and Oral Medicine and Biology, The Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California Los Angeles, Le Conte Ave 10833, Los Angeles, CA, 90095, USA

    Ichiro Nishimura

Authors
  1. Ichiro Nishimura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ichiro Nishimura .

Editor information

Editors and Affiliations

  1. School of Dentistry, University of Manchester, Higher Cambridge Street, Manchester, M15 6FH, United Kingdom

    Hugh Devlin

  2. School of Dentistry, University of California Los Angeles, Le Conte Ave 10833, Los Angeles, 90095-1668, California, USA

    Ichiro Nishimura

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Nishimura, I. (2013). Genetic Background of Implant Failure. In: Devlin, H., Nishimura, I. (eds) Oral and Cranial Implants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34225-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-34225-7_4

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-34224-0

  • Online ISBN: 978-3-642-34225-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation