Abstract
Mankind’s fascination with symmetry can be traced back to early civilizations in art, sculpture, architecture, music, and many other forms. Certainly, the bilateral symmetry of the human form and other life forms supports the idea that symmetry confers significant evolutionary advantages. It is therefore not surprising that in the world of complex molecules, many examples of symmetrical molecules can be found, which undoubtedly also provide an evolutionary advantage to the producing organism. Yet, as one more critically analyzes the structures of natural products that possess some element of symmetry, it becomes apparent that pseudosymmetry may, in fact, be more common and a key to an as of yet underappreciated subtlety of evolution. It was in the wake of these musings that we first started to ponder the pseudosymmetric, complex Lycopodium alkaloid complanadine A (1, Fig. 11.1).
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Sarpong, R., Fischer, D.F. (2012). Total Synthesis of the Lycopodium Alkaloid Complanadine A. In: Li, J., Corey, E. (eds) Total Synthesis of Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34065-9_11
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