Abstract
Different pathways that transform metabolic energy to heat are described. Mechanisms of \( \Updelta \bar{\mu }_{{{\text{H}}^{ + } }} \)-dependent thermogenesis in brown fat and skeletal muscle of warm-blooded animals are thoroughly discussed. Fatty acid-induced uncoupling of oxidative phosphorylation in mitochondria as well as mediation of this effect by UCP1 and other carriers are described. Activation of the free oxidation pathway in mitochondria of thermogenic plants is also reviewed.
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According to this hypothesis, UCP is a monofunctional version of an ATP/ADP-antiporter which has lost its main (nucleotide-transporting) function and specializes in a supplementary function, i.e., fatty acid-mediated uncoupling provided through transport of their anions.
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Skulachev, V.P., Bogachev, A.V., Kasparinsky, F.O. (2013). \( \Updelta \bar{\mu }_{{{\text{H}}^{ + } }} \) as Energy Source for Heat Production. In: Principles of Bioenergetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33430-6_10
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DOI: https://doi.org/10.1007/978-3-642-33430-6_10
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