Abstract
The Multi-electrode Array (MEA) technology allows the in-vitro culture of neuronal networks that can be used as a simplified and accessible model of the central nervous system, given that they exhibit activity patterns similar to the in-vivo tissue. Current devices generate huge amounts of data, thus motivating the development of systems capable of discriminating diverse cultured neuronal network activity patterns. In this paper, we describe the use of Inter-Spike Interval statistics coupled to data compression statistics in two discrimination applications. One of them concerning spontaneous vs. stimulated activity patterns, and the other concerning spontaneous responses from a control culture of neurons and a previously treated one. We show that the data compression ratio of the trains of spikes emerging from those cultures can be used to enhance the discrimination performance.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abasolo, D., et al.: Entropy analysis of the EEG background activity in alzheimers disease patients. Physiological Measurement 27(3), 241–253 (2006)
Bao, F.S., et al.: Automated epilepsy diagnosis using interictal scalp EEG. In: Proc. of the IEEE EMBC 2009 Conference, pp. 6603–6607 (2009)
Berthold, B.: Entropy. Best Practice and Research Clinical Anaesthesiology 20(1), 101–109 (2006)
Bishop, C.: Neural networks for pattern recognition. OUP, USA (1995)
Chen, L., et al.: Characterizing the complexity of spontaneous electrical signals in cultured neuronal networks using approximate entropy. In: IEEE Int. Conf. Inf. Tech. Appl. Biomed, vol. 13(3), pp. 405–410 (2009)
Heuschkel, M.: A three-dimensional multi-electrode array for stimulation and recording in acute brain slices. J. of Neuroscience Methods 114, 135–148 (2002)
Heuschkel, M., et al.: The PharMEA platform: A high throughput data acquisition instrument integrating real-time data analysis, data reduction, and wellplate-format microelectrode arrays. Submitted to the 8th International Meeting on Substrate-Integrated Microelectrode Arrays (2012)
Morris, R., Anderson, E., Lynch, G., Baudry, M.: Selective impairment of learning and blockade of long-term potentiation by an n-methyl-d-aspartate receptor antagonist, ap5. Nature 319, 774–776 (1986)
Pincus, S.M.: Approximate entropy as a measure of system complexity. PNAS 88(6), 2297–2301 (1991)
R Core Team: R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria (2012), http://www.R-project.org/
Sabeti, M., Katebi, S., Boostani, R.: Entropy and complexity measures for EEG signal classification of schizophrenic and control participants. Artificial Intelligence in Medicine 47(3), 263–274 (2009)
Taketani, M., Baudry, M.: Advances in network electrophysiology: using multi-electrode arrays, vol. 2010. Springer (2006)
Yeh, F.C., et al.: Maximum entropy approaches to living neural networks. Entropy 12(1), 89–106 (2010)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Perez-Uribe, A., Satizábal, H.F. (2012). Artificial Neural Networks and Data Compression Statistics for the Discrimination of Cultured Neuronal Activity. In: Villa, A.E.P., Duch, W., Érdi, P., Masulli, F., Palm, G. (eds) Artificial Neural Networks and Machine Learning – ICANN 2012. ICANN 2012. Lecture Notes in Computer Science, vol 7552. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33269-2_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-33269-2_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-33268-5
Online ISBN: 978-3-642-33269-2
eBook Packages: Computer ScienceComputer Science (R0)