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Scientific and Managerial Premises and Unresolved Issues in Tumour Biobanking Activities

  • Mattia BarbareschiEmail author
  • Silvia Fasanella
  • Chiara Cantaloni
  • Silvia Giuliani
Chapter
First Online:

Abstract

Research biobanks are organisations that collect and preserve human biological materials, according to ethical and legal rules, in order to supply researchers with high quality human specimens for scientific purposes, accompanied by as much data as possible. Disease-oriented biobanks are aimed at collecting biomaterials pertaining to specific pathological conditions, and among them are tumour biobanks. High-quality biobanking relies on several aspects, which include long-term funding, appropriate ethical and legal framework, active involvement of patients and the medical community, quality of samples and of the corresponding data, proper regulation of the procedures for distributing biomaterials, appropriate Information Technology (IT) infrastructure, networking in a national and international environment. In this essay we will focus our attention on some of these aspects, describing, in particular, the workflow and organisation of a specific type of biobank: the tumour biobank. Our analysis is based on the experience developed in the recently established Trentino Biobank (TBB), which is a paradigmatic biobanking project in Italy.

Keywords

Unresolved Issue Proper Regulation Leftover Tissue Specific Research Project Research Biobanks 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgements

Trentino Biobank is supported by Fondazione Cassa di Risparmio di Trento e Rovereto and by the Autonomous Province of Trento through the Provincial Health Service Authority.

References

  1. Barbareschi M, Cotrupi S, Guarrera GM (2008) Biobanks: instrumentation, personnel and cost analysis. Pathologica 100:139–148Google Scholar
  2. Carter A, Betsou F (2011) Quality assurance in cancer biobanking. Biopreserv Biobank 9(2):157–163CrossRefGoogle Scholar
  3. Galvagni M, Cotrupi S, Barbareschi M (2008) Biobanks and information technology. Pathologica 100:116–138Google Scholar
  4. Hansson MG (2010) Need for a wider view of autonomy in epidemiological research. Br Med J 340:c233CrossRefGoogle Scholar
  5. Hansson MG, Dillner J, Bartram CR, Carlson JA, Helgesson G (2006) Should donors be allowed to give broad consent to future biobank research? Lancet Oncol 7:266–269CrossRefGoogle Scholar
  6. IARC Working Group Reports (2008) Common minimum technical standards and protocols for biological resource centres dedicated to cancer research. In: Caboux E, Plymoth A, Hainaut P (eds) WorkGroup Report 2. IARC, LyonGoogle Scholar
  7. ISBER (2008) Best practices for repositories, collection, storage, retrieval and distribution of biological materials for research. Cell Preserv Technol 6(1)Google Scholar
  8. Macilotti M, Izzo U, Pascuzzi G, Barbareschi M (2008) Legal aspects of biobanks. Pathologica 100:86–115Google Scholar
  9. Mager SR, Oomen MH, Morente MM, Ratcliffe C, Knox K, Kerr DJ, Pezzella F, Riegman PH (2007) Standard operating procedure for the collection of fresh frozen tissue samples. Eur J Cancer 43:828–834CrossRefGoogle Scholar
  10. Mathot L, Lindman M, Sjoblom T (2011) Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples. Chem Commun 47:547–549CrossRefGoogle Scholar
  11. Morente MM, Mager R, Alonso S, Pezzella F, Spatz A, Knox K et al (2006) TuBaFrost 2: standardising tissue collection and quality control procedures for a european virtual frozen tissue bank network. Eur J Cancer 42:2684–2691CrossRefGoogle Scholar
  12. Muyal JP, Muyal V, Kaistha BP, Seifart C, Fehrenbach H (2009) Systematic comparison of RNA extraction techniques from frozen and fresh tissues: checkpoint towards gene expression studies. Diagn Pathol 4:9CrossRefGoogle Scholar
  13. Oosterhuis JW, Coebergh JW, van Veen EB (2003) Tumour banks: well-guarded treasures in the interest of patients. Nat Rev Cancer 3:73–77CrossRefGoogle Scholar
  14. Petrini C (2010a) “Broad” consent, exceptions to consent and the question of using biological samples for research purposes different from the initial collection purpose. Soc Sci Med 70:217–220CrossRefGoogle Scholar
  15. Petrini C (2010b) Ethical issues with informed consent from potential living kidney donors. Transplant Proc 42:1040–1042CrossRefGoogle Scholar
  16. Riegman PHJ, van Veen E (2011) Biobanking residual tissues. Hum Genet 130:357–368CrossRefGoogle Scholar
  17. Riegman PH, Morente MM, Betsou F, de Blasio P, Geary P (2008) Biobanking for better healthcare. Mol Oncol 2:213–222CrossRefGoogle Scholar
  18. Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, Masys DR (2008) Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther 84(3):362–369CrossRefGoogle Scholar
  19. Stanta G, Bonin S, Machado I, Llombart-Bosch A (2011) Models of biobanking and tissue preservation: RNA quality in archival samples in pathology laboratories and “In Vivo Biobanking” by tumor xenografts in nude mice-two models of quality assurance in pathology. Biopreserv Biobank 9(2):149–155CrossRefGoogle Scholar
  20. Strand C, Enell J, Hedenfalk I, Fernö M (2007) RNA quality in frozen breast cancer samples and the influence on gene expression analysis a comparison of three evaluation methods using microcapillary electrophoresis traces. BMC Mol Biol 8:38CrossRefGoogle Scholar
  22. Yuille M, Illig T, Hveem K, Schmitz G, Hansen J, Neumaier M, Tybring G, Wichmann E, Ollier B (2010) Laboratory management of samples in biobanks: European Consensus Expert Group report. Biopreserv Biobank 8(1):65–69CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Mattia Barbareschi
    • 1
    • 2
    Email author
  • Silvia Fasanella
    • 2
  • Chiara Cantaloni
    • 2
  • Silvia Giuliani
    • 2
  1. 1.Unit of Surgical Pathology, Laboratory of Molecular PathologyS. Chiara HospitalTrentoItaly
  2. 2.Trentino Biobank, S. Chiara HospitalTrentoItaly

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