Abstract
In recent years, there has been a growing interest in the area of brain connectivity. In particular, brain connectivity analyses using either functional or effective connectivity have been performed to look at functional integration between various cortical areas in the field of brain research. MEG has been widely used as a tool for presurgical mapping of epilepsy. But attempts to take advantage of technical advances of brain connectivity have been made and provided valuable information in addition to the conventional technique. Here, we discussed what we have learned from recent studies on the investigation of brain connectivity in epilepsy using MEG and future directions for this field.
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References
Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10(3):186–198
Chavez M, Valencia M, Navarro V, Latora V, Martinerie J (2010) Functional modularity of background activities in normal and epileptic brain networks. Phys Rev Lett 104(11):118701
Colon AJ, Ossenblok P, Nieuwenhuis L, Stam KJ, Boon P (2009) Use of routine MEG in the primary diagnostic process of epilepsy. J Clin Neurophysiol 26(5):326–332
Dai Y, Zhang W, Dickens DL, He B (2012) Source connectivity analysis from MEG and its application to epilepsy source localization. Brain Topogr 25(2):157–166
Douw L, van Dellen E, de Groot M, Heimans JJ, Klein M, Stam CJ, Reijneveld JC (2010) Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients. BMC Neurosci 11:103
Engel J Jr, Thompson PM, Stern JM, Staba RJ, Bragin A, Mody I (2013) Connectomics and epilepsy. Curr Opin Neurol 26(2):186–194
Friston K (2002) Beyond phrenology: what can neuroimaging tell us about distributed circuitry? Annu Rev Neurosci 25:221–250
Friston KJ (2005) Models of brain function in neuroimaging. Annu Rev Psychol 56:57–87
Friston KJ (2009) Modalities, modes, and models in functional neuroimaging. Science 326(5951):399–403
Friston KJ (2011) Functional and effective connectivity: a review. Brain Connect 1(1):13–36
Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6(3):218–229
Funke ME, Moore K, Orrison WW Jr, Lewine JD (2011) The role of magnetoencephalography in “nonlesional” epilepsy. Epilepsia 52(Suppl 4):10–14
Glerean E, Salmi J, Lahnakoski JM, Jaaskelainen IP, Sams M (2012) Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivity. Brain Connect 2(2):91–101
Jin SH, Chung CK (2012) Messages from the brain connectivity regarding neural correlates of consciousness. Exp Neurobiol 21(3):113–122
Jin SH, Jeong W, Chung CK (2013) Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia. Epilepsy Res 105(1-2):118–124
Liao W, Zhang Z, Pan Z, Mantini D, Ding J, Duan X, Luo C, Lu G, Chen H (2010) Altered functional connectivity and small-world in mesial temporal lobe epilepsy. PLoS ONE 5(1):e8525
Reijneveld JC, Ponten SC, Berendse HW, Stam CJ (2007) The application of graph theoretical analysis to complex networks in the brain. Clin Neurophysiol 118(11):2317–2331
Sporns O (2011) Networks of the brain. MIT Press, Cambridge
Stefan H, Rampp S, Knowlton RC (2011a) Magnetoencephalography adds to the surgical evaluation process. Epilepsy Behav 20(2):172–177
Stefan H, Wu X, Buchfelder M, Rampp S, Kasper B, Hopfengartner R, Schmitt F, Dorfler A, Blumcke I, Zhou D, Weigel D (2011b) MEG in frontal lobe epilepsies: localization and postoperative outcome. Epilepsia 52(12):2233–2238
Stufflebeam SM (2011) Clinical magnetoencephalography for neurosurgery. Neurosurg Clin N Am 22(2):153–167, vii–viii
Stufflebeam SM, Tanaka N, Ahlfors SP (2009) Clinical applications of magnetoencephalography. Hum Brain Mapp 30(6):1813–1823
Tononi G, Sporns O, Edelman GM (1994) A measure for brain complexity: relating functional segregation and integration in the nervous system. Proc Natl Acad Sci USA 91(11):5033–5037
Zeki SM (1978) Functional specialisation in the visual cortex of the rhesus monkey. Nature 274(5670):423–428
Zeki S, Shipp S (1988) The functional logic of cortical connections. Nature 335(6188):311–317
Zhang Z, Liao W, Chen H, Mantini D, Ding JR, Xu Q, Wang Z, Yuan C, Chen G, Jiao Q, Lu G (2011) Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain 134(Pt 10):2912–2928
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Jin, SH., Chung, C.K. (2014). Towards Brain Connectivity in Epilepsy Using MEG. In: Supek, S., Aine, C. (eds) Magnetoencephalography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33045-2_40
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DOI: https://doi.org/10.1007/978-3-642-33045-2_40
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