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Computing Hopf Bifurcations in Chemical Reaction Networks Using Reaction Coordinates

  • Hassan Errami
  • Werner M. Seiler
  • Markus Eiswirth
  • Andreas Weber
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7442)

Abstract

The analysis of dynamic of chemical reaction networks by computing Hopf bifurcation is a method to understand the qualitative behavior of the network due to its relation to the existence of oscillations. For low dimensional reaction systems without additional constraints Hopf bifurcation can be computed by reducing the question of its occurrence to quantifier elimination problems on real closed fields. However deciding its occurrence in high dimensional system has proven to be difficult in practice. In this paper we present a fully algorithmic technique to compute Hopf bifurcation fixed point for reaction systems with linear conservation laws using reaction coordinates instead of concentration coordinates, a technique that extends the range of networks, which can be analyzed in practice, considerably.

Keywords

Hopf Bifurcation Invariant Manifold System Biology Markup Language Stoichiometric Matrix Chemical Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Hassan Errami
    • 1
  • Werner M. Seiler
    • 1
  • Markus Eiswirth
    • 2
    • 3
  • Andreas Weber
    • 4
  1. 1.Institut für MathematikUniversität KasselKasselGermany
  2. 2.Fritz-Haber Institut der Max-Planck-GesellschaftBerlinGermany
  3. 3.Ertl Center for Electrochemisty and CatalysisGwangju Institute of Science and Technology (GIST)South Korea
  4. 4.Institut für Informatik IIUniversität BonnBonnGermany

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