Systems biology is an attempt to understand biological system as system thereby triggering innovations in medical practice, drug discovery, bio-engineering, and global sustainability problems. The fundamental difficulties lies in the complexity of biological systems that have evolved through billions of years. Nevertheless, there are fundamental principles governing biological systems as complex evolvable systems that has been optimized for certain environmental constraints. Broad range of AI technologies can be applied for systems biology such as text-mining, qualitative physics, marker-passing algorithms, statistical inference, machine learning, etc. In fact, systems biology is one of the best field that AI technologies can be best applied to make high impact research that can impact real-world. This talk addresses basic issues in systems biology, especially in systems drug discovery and coral reef systems biology, and discusses how AI can contribute to make difference.