Abstract
In this chapter, the kinematic and kinetic changes in the knee after ACL injury are discussed. Human motion analysis supports the observation that altered rotational positions in the ACL-deficient knee lead to changes in tibiofemoral contact during walking. The interaction between altered joint kinematics and the structural and biological components of articular cartilage are explored as an initiating mechanism of premature cartilage degradation following ACL injury. This mechanism provides a framework for studying OA that unifies kinematic and biological investigations and should form the development of techniques to prevent the initiation and progression of OA in the ACL-injured population.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abebe ES, Utturkar GM, Taylor DC et al (2011) The effects of femoral graft placement on in vivo knee kinematics after anterior cruciate ligament reconstruction. J Biomech 44(5):924–929
Ahmed AM, Burke DL (1983) In-vitro measurement of static pressure distribution in synovial joints – part I: tibial surface of the knee. J Biomech Eng 105(3):216–225
Ait Si Selmi T, Fithian D, Neyret P (2006) The evolution of osteoarthritis in 103 patients with ACL reconstruction at 17 years follow-up. Knee 13(5):353–358
Andriacchi TP, Mundermann A, Smith RL et al (2004) A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng 32(3):447–457
Andriacchi TP, Dyrby CO (2005) Interactions between kinematics and loading during walking for the normal and ACL deficient knee. J Biomech 38(2):293–298
Andriacchi TP, Mundermann A (2006) The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr Opin Rheumatol 18(5):514–518
Andriacchi TP, Koo S, Scanlan SF (2009) Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee. J Bone Joint Surg Am 91(Suppl 1):95–101
Appleyard RC, Burkhardt D, Ghosh P et al (2003) Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis. Osteoarthritis Cartilage 11(1):65–77
Barrance PJ, Williams GN, Snyder-Mackler L et al (2006) Altered knee kinematics in ACL-deficient non-copers: a comparison using dynamic MRI. J Orthop Res 24(2):132–140
Bedi A, Raphael B, Maderazo A et al (2010) Transtibial versus anteromedial portal drilling for anterior cruciate ligament reconstruction: a cadaveric study of femoral tunnel length and obliquity. Arthroscopy 26(3):342–350
Behrens F, Kraft EL, Oegema TR Jr (1989) Biochemical changes in articular cartilage after joint immobilization by casting or external fixation. J Orthop Res 7(3):335–343
Bevill SL, Briant PL, Levenston ME et al (2009) Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression. Osteoarthritis Cartilage 17(8):980–987
Bullough PG, Yawitz PS, Tafra L et al (1985) Topographical variations in the morphology and biochemistry of adult canine tibial plateau articular cartilage. J Orthop Res 3(1):1–16
Buschmann MD, Kim YJ, Wong M et al (1999) Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow. Arch Biochem Biophys 366(1):1–7
Chaganti RK, Lane NE (2011) Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med 4(3):99–104
Chaudhari AM, Briant PL, Bevill SL et al (2008) Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exerc 40(2):215–222
Chowdhury TT, Bader DL, Lee DA (2006) Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology 43(3–4):413–429
Clark JM (1991) Variation of collagen fiber alignment in a joint surface: a scanning electron microscope study of the tibial plateau in dog, rabbit, and man. J Orthop Res 9(2):246–257
Daniel DM, Stone ML, Dobson BE et al (1994) Fate of the ACL-injured patient. A prospective outcome study. Am J Sports Med 22(5):632–644
Das P, Schurman DJ, Smith RL (1997) Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear. J Orthop Res 15(1):87–93
Defrate LE, Papannagari R, Gill TJ et al (2006) The 6 degrees of freedom kinematics of the knee after anterior cruciate ligament deficiency: an in vivo imaging analysis. Am J Sports Med 34(8):1240–1246
Deschner J, Hofman CR, Piesco NP et al (2003) Signal transduction by mechanical strain in chondrocytes. Curr Opin Clin Nutr Metab Care 6(3):289–293
Deschner J, Rath-Deschner B, Agarwal S (2006) Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes. Osteoarthritis Cartilage 14(3):264–272
Durrant LA, Archer CW, Benjamin M et al (1999) Organisation of the chondrocyte cytoskeleton and its response to changing mechanical conditions in organ culture. J Anat 194(Pt 3):343–353
Eggli PS, Hunziker EB, Schenk RK (1988) Quantitation of structural features characterizing weight- and less-weight-bearing regions in articular cartilage: a stereological analysis of medial femoral condyles in young adult rabbits. Anat Rec 222(3):217–227
Elder SH, Goldstein SA, Kimura JH et al (2001) Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng 29(6):476–482
Erhart JC, Dyrby CO, D’Lima DD et al (2010) Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction moment. J Orthop Res 28(12):1548–1553
Fedewa MM, Oegema TR Jr, Schwartz MH et al (1998) Chondrocytes in culture produce a mechanically functional tissue. J Orthop Res 16(2):227–236
Forster H, Fisher J (1999) The influence of continuous sliding and subsequent surface wear on the friction of articular cartilage. Proc Inst Mech Eng H 213(4):329–345
Freeman PM, Natarajan RN, Kimura JH et al (1994) Chondrocyte cells respond mechanically to compressive loads. J Orthop Res 12(3):311–320
Fujisawa T, Hattori T, Takahashi K et al (1999) Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1. J Biochem 125(5):966–975
Fukubayashi T, Torzilli PA, Sherman MF (1982) An in vitro biomechanical evaluation of anterior-posterior motion of the knee. Tibial displacement, rotation, and torque. J Bone Joint Surg Am 64A(2):258–264
Georgoulis AD, Papadonikolakis A, Papageorgiou CD et al (2003) Three-dimensional tibiofemoral kinematics of the anterior cruciate ligament-deficient and reconstructed knee during walking. Am J Sports Med 31(1):75–79
Guilak F, Ratcliffe A, Lane N et al (1994) Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. J Orthop Res 12(4):474–484
Hasler EM, Herzog W, Leonard TR et al (1998) In vivo knee joint loading and kinematics before and after ACL transection in an animal model. J Biomech 31(3):253–262
Ikenoue T, Trindade MC, Lee MS et al (2003) Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro. J Orthop Res 21(1):110–116
Kannus P, Jarvinen M (1989) Posttraumatic anterior cruciate ligament insufficiency as a cause of osteoarthritis in a knee joint. Clin Rheumatol 8(2):251–260
Kiviranta I, Jurvelin J, Tammi M et al (1987) Weight bearing controls glycosaminoglycan concentration and articular cartilage thickness in the knee joints of young beagle dogs. Arthritis Rheum 30(7):801–809
Kiviranta I, Tammi M, Jurvelin J et al (1988) Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs. J Orthop Res 6(2):188–195
Knight MM, Ross JM, Sherwin AF et al (2001) Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta 1526(2):141–146
Koo S, Andriacchi TP (2007) A comparison of the influence of global functional loads vs. local contact anatomy on articular cartilage thickness at the knee. J Biomech 40(13):2961–2966
Koo S, Andriacchi TP (2008) The knee joint center of rotation is predominantly on the lateral side during normal walking. J Biomech 41(6):1269–1273
Kumm JA, Tamm, Lintrop M et al (2011) The prevalence and progression of radiographic knee osteoarthritis over 6 years in a population-based cohort of middle-aged subjects. Rheumatol Int.http://www.ncbi.nlm.nih.gov/pubmed/22083615. Epub ahead of print, Nov 16, 2011. DOI:10.1007/s00296-011-2221-3
Lee DA, Bader DL (1997) Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res 15(2):181–188
Li G, Park SE, DeFrate LE (2005) The cartilage thickness distribution in the tibiofemoral joint and its correlation with cartilage-to-cartilage contact. Clin Biomech (Bristol, Avon) 20(7):736–744
Li G, Moses JM, Papannagari R et al (2006) Anterior cruciate ligament deficiency alters the in vivo motion of the tibiofemoral cartilage contact points in both the anteroposterior and mediolateral directions. J Bone Joint Surg Am 88(8):1826–1834
Liphardt AM, Mundermann A, Koo S et al (2009) Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization. Osteoarthritis Cartilage 17(12):1598–1603
Little CB, Ghosh P (1997) Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading. Osteoarthritis Cartilage 5(1):49–62
Liu W, Burton-Wurster N, Glant TT et al (2003) Spontaneous and experimental osteoarthritis in dog: similarities and differences in proteoglycan levels. J Orthop Res 21(4):730–737
Logan MC, Williams A, Lavelle J et al (2004) Tibiofemoral kinematics following successful anterior cruciate ligament reconstruction using dynamic multiple resonance imaging. Am J Sports Med 32(4):984–992
Lohmander LS, Ostenberg A, Englund M et al (2004) High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum 50(10):3145–3152
Maletius W, Messner K (1999) Eighteen- to twenty-four-year follow-up after complete rupture of the anterior cruciate ligament. Am J Sports Med 27(6):711–717
Maniwa S, Nishikori T, Furukawa S et al (2001) Alteration of collagen network and negative charge of articular cartilage surface in the early stage of Âexperimental osteoarthritis. Arch Orthop Trauma Surg 121(4):181–185
Markolf KL, Mensch JS, Amstutz HC (1976) Stiffness and laxity of the knee – the contributions of the supporting structures. A quantitative in vitro study. J Bone Joint Surg Am 58(5):583–594
Meuffels DE, Favejee MM, Vissers MM et al (2009) Ten year follow-up study comparing conservative versus operative treatment of anterior cruciate ligament ruptures. A matched-pair analysis of high level athletes. Br J Sports Med 43(5):347–351
Mow VC, Kuei SC, Lai WM et al (1980) Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J Biomech Eng 102(1):73–84
Netravali NA, Giori NJ, Andriacchi TP (2010) Partial medial meniscectomy and rotational differences at the knee during walking. J Biomech 43(15):2948–2953
Nguyen US, Zhang Y, Zhu Y et al (2011) Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med 155(11):725–732
Oiestad BE, Holm I, Aune AK et al (2010) Knee function and prevalence of knee osteoarthritis after anterior cruciate ligament reconstruction: a prospective study with 10 to 15 years of follow-up. Am J Sports Med 38(11):2201–2210
Pelletier JP, Mineau F, Faure MP et al (1990) Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis. Arthritis Rheum 33(10):1466–1476
Quinn TM, Grodzinsky AJ, Buschmann MD et al (1998) Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants. J Cell Sci 111(Pt 5):573–583
Quinn TM, Hunziker EB, Hauselmann HJ (2005) Variation of cell and matrix morphologies in articular cartilage among locations in the adult human knee. Osteoarthritis Cartilage 13(8):672–678
Ristanis S, Stergiou N, Siarava E et al (2009) Effect of femoral tunnel placement for reconstruction of the anterior cruciate ligament on tibial rotation. J Bone Joint Surg Am 91(9):2151–2158
Scanlan SF, Blazek K, Chaudhari AM et al (2009) Graft orientation influences the knee flexion moment during walking in patients with anterior cruciate ligament reconstruction. Am J Sports Med 37(11):2173–2178
Scanlan SF, Chaudhari AM, Dyrby CO et al (2010) Differences in tibial rotation during walking in ACL reconstructed and healthy contralateral knees. J Biomech 43(9):1817–1822
Scarvell JM, Smith PN, Refshauge KM et al (2005) Comparison of kinematics in the healthy and ACL injured knee using MRI. J Biomech 38(2):255–262
Schipplein OD, Andriacchi TP (1991) Interaction between active and passive knee stabilizers during level walking. J Orthop Res 9(1):113–119
Smith RL, Donlon BS, Gupta MK et al (1995) Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro. J Orthop Res 13(6):824–831
Smith RL, Trindade MC, Ikenoue T et al (2000) Effects of shear stress on articular chondrocyte metabolism. Biorheology 37(1):95–107
Sohn DH, Garrett WE Jr (2009) Transitioning to anatomic anterior cruciate ligament graft placement. J Knee Surg 22(2):155–160
Tashman S, Anderst W, Kolowich P et al (2004) Kinematics of the ACL-deficient canine knee during gait: serial changes over two years. J Orthop Res 22(5):931–941
Tashman S, Collon D, Anderson K et al (2004) Abnormal rotational knee motion during running after anterior cruciate ligament reconstruction. Am J Sports Med 32(4):975–983
Vanwanseele B, Eckstein F, Knecht H et al (2002) Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement. Arthritis Rheum 46(8):2073–2078
Vanwanseele B, Eckstein F, Knecht H et al (2003) Longitudinal analysis of cartilage atrophy in the knees of patients with spinal cord injury. Arthritis Rheum 48(12):3377–3381
Videman T (1982) Experimental osteoarthritis in the rabbit: comparison of different periods of repeated immobilization. Acta Orthop Scand 53(3):339–347
Vilensky JA, O’Connor BL, Brandt KD et al (1994) Serial kinematic analysis of the unstable knee after transection of the anterior cruciate ligament: temporal and angular changes in a canine model of osteoarthritis. J Orthop Res 12(2):229–237
von Porat A, Roos EM, Roos H (2004) High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis 63(3):269–273
Wang H, Ateshian GA (1997) The normal stress effect and equilibrium friction coefficient of articular cartilage under steady frictional shear. J Biomech 30(8):771–776
Wilson W, Driessen NJ, van Donkelaar CC et al (2006) Prediction of collagen orientation in articular cartilage by a collagen remodeling algorithm. Osteoarthritis Cartilage 14(11):1196–1202
Wong M, Wuethrich P, Buschmann MD et al (1997) Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage. J Orthop Res 15(2):189–196
Yoshioka M, Coutts RD, Amiel D et al (1996) Characterization of a model of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 4(2):87–98
Zhao D, Banks SA, Mitchell KH et al (2007) Correlation between the knee adduction torque and medial contact force for a variety of gait patterns. J Orthop Res 25(6):789–797
Acknowledgment
The authors would like to thank Maurice Manring, Ph.D. for his editorial assistance with this manuscript.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chaudhari, A.M.W., Schmitt, L.C., Andriacchi, T.P. (2012). Effects of Alterations in Gait Mechanics on the Development of Osteoarthritis in the ACL-Deficient Knee. In: Noyes, F., Barber-Westin, S. (eds) ACL Injuries in the Female Athlete. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32592-2_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-32592-2_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-32591-5
Online ISBN: 978-3-642-32592-2
eBook Packages: MedicineMedicine (R0)