Abstract
This chapter discusses long-term data from ACL reconstruction studies, the factors that are most likely related to increased risk of developing arthritis, and causes of failure of surgery. While data from most ACL reconstruction studies show favorable results in terms of improved knee stability and function, the outcome in terms of prevalence of osteoarthritis in long-term studies is highly variable. Factors that may cause eventual knee arthritis include meniscectomy, abnormal knee kinematics, severe bone bruising, damage to other knee ligament structures, alteration in the biochemical environment, chondral fractures or lesions, excessive uncorrected varus or valgus lower limb malalignment, obesity, familial predisposition, and long-term participation in high impact sports activities. The problem exists that ACL reconstruction does not fully restore normal knee kinematics, despite advanced surgical procedures and rehabilitation. The published rates of either reinjuring an ACL-reconstructed knee or sustaining an ACL rupture on the contralateral knee upon return to activities after surgery vary widely from 3 to 40 %.
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References
Adalberth T, Roos H, Lauren M et al (1997) Magnetic resonance imaging, scintigrapy, and arthroscopic evaluation of traumatic hemarthrosis of the knee. Am J Sports Med 25(2):231–237
Aglietti P, Buzzi R, Giron F (1997) Arthroscopic-assisted anterior cruciate ligament reconstruction with the central third patellar tendon. A 5–8-year follow-up. Knee Surg Sports Traumatol Arthrosc 5(3):138–144
Ait Si Selmi T, Fithian D, Neyret P (2006) The evolution of osteoarthritis in 103 patients with ACL reconstruction at 17 years follow-up. Knee 13(5):353–358
Barber-Westin SD, Heckmann TP, Noyes FR (2009) Scientific basis of rehabilitation after anterior cruciate ligament autogenous reconstruction. In: Noyes FR (ed) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 268–305
Barber-Westin SD, Hermeto AA, Noyes FR (2010) A 6-week neuromuscular training program for competitive junior tennis players. J Strength Cond Res 24(9):2372–2382
Barber-Westin SD, Noyes FR (2011) Factors used to determine return to unrestricted sports activities after anterior cruciate ligament reconstruction. Arthroscopy 27(12):1697–1705
Barber-Westin SD, Noyes FR (2011) Objective criteria for return to athletics after anterior cruciate ligament reconstruction and subsequent reinjury rates: a systematic review. Phys Sportsmed 39(3):100–110
Bedi A, Rodeo SA (2009) Biology of anterior cruciate ligament graft healing. In: Noyes FR (ed) Noyes knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 117–129
Beynnon BD, Johnson RJ, Abate JA et al (2005) Treatment of anterior cruciate ligament injuries, part I. Am J Sports Med 33(10):1579–1602
Beynnon BD, Uh BS, Johnson RJ et al (2005) Rehabilitation after anterior cruciate ligament reconstruction. A prospective, randomized, double-blind comparison of programs administered over 2 different time periods. Am J Sports Med 33(3):347–359
Buseck MS, Noyes FR (1991) Arthroscopic evaluation of meniscal repairs after anterior cruciate ligament reconstruction and immediate motion. Am J Sports Med 19(5):489–494
Cameron ML, Fu FH, Paessler HH et al (1994) Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee. Knee Surg Sports Traumatol Arthrosc 2(1):38–44
Cohen M, Amaro JT, Ejnisman B et al (2007) Anterior cruciate ligament reconstruction after 10 to 15 years: association between meniscectomy and osteoarthrosis. Arthroscopy 23(6):629–634
Costa-Paz M, Muscolo DL, Ayerza M et al (2001) Magnetic resonance imaging follow-up study of bone bruises associated with anterior cruciate ligament ruptures. Arthroscopy 17(5):445–449
Davies NH, Niall D, King LJ et al (2004) Magnetic resonance imaging of bone bruising in the acutely injured knee – short-term outcome. Clin Radiol 59(5):439–445
Deehan DJ, Salmon LJ, Webb VJ et al (2000) Endoscopic reconstruction of the anterior cruciate ligament with an ipsilateral patellar tendon autograft. J Bone Joint Surg 82-B(7):984–991
Diamantopoulos A, Tokis A, Tzurbakis M et al (2005) The posterolateral corner of the knee: evaluation under microsurgical dissection. Arthroscopy 21(7):826–833
Diamantopoulos AP, Lorbach O, Paessler HH (2008) Anterior cruciate ligament revision reconstruction: results in 107 patients. Am J Sports Med 36(5):851–860
Drogset JO, Grontvedt T, Robak OR et al (2006) A sixteen-year follow-up of three operative techniques for the treatment of acute ruptures of the anterior cruciate ligament. J Bone Joint Surg Am 88(5):944–952
Elsaid KA, Fleming BC, Oksendahl HL et al (2008) Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 58(6):1707–1715
Engebretsen L, Arendt E, Fritts HM (1993) Osteochondral lesions and cruciate ligament injuries. MRI in 18 knees. Acta Orthop Scand 64(4):434–436
Even-Sapir E, Arbel R, Lerman H et al (2002) Bone injury associated with anterior cruciate ligament and meniscal tears: assessment with bone single photon emission computed tomography. Invest Radiol 37(9):521–527
Faber KJ, Dill JR, Amendola A et al (1999) Occult osteochondral lesions after anterior cruciate ligament rupture. Six-year magnetic resonance imaging follow-up study. Am J Sports Med 27(4):489–494
Fang C, Johnson D, Leslie MP et al (2001) Tissue distribution and measurement of cartilage oligomeric matrix protein in patients with magnetic resonance imaging-detected bone bruises after acute anterior cruciate ligament tears. J Orthop Res 19(4):634–641
Fink C, Hoser C, Hackl W et al (2001) Long-term outcome of operative or nonoperative treatment of anterior cruciate ligament rupture – is sports activity a determining variable? Int J Sports Med 22(4):304–309
Frobell RB, Le Graverand MP, Buck R et al (2009) The acutely ACL injured knee assessed by MRI: changes in joint fluid, bone marrow lesions, and cartilage during the first year. Osteoarthritis Cartilage 17(2):161–167
Frobell RB (2011) Change in cartilage thickness, posttraumatic bone marrow lesions, and joint fluid volumes after acute ACL disruption: a two-year prospective MRI study of sixty-one subjects. J Bone Joint Surg Am 93(12):1096–1103
George MS, Dunn WR, Spindler KP (2006) Current concepts review: revision anterior cruciate ligament reconstruction. Am J Sports Med 34(12):2026–2037
Graf BK, Cook DA, De Smet AA et al (1993) “Bone bruises” on magnetic resonance imaging evaluation of anterior cruciate ligament injuries. Am J Sports Med 21(2):220–223
Hanypsiak BT, Spindler KP, Rothrock CR et al (2008) Twelve-year follow-up on anterior cruciate ligament reconstruction: long-term outcomes of prospectively studied osseous and articular injuries. Am J Sports Med 36(4):671–677
Hart AJ, Buscombe J, Malone A et al (2005) Assessment of osteoarthritis after reconstruction of the anterior cruciate ligament: a study using single-photon emission computed tomography at ten years. J Bone Joint Surg Br 87(11):1483–1487
Heckmann TP, Noyes FR, Barber-Westin SD (2009) Rehabilitation of meniscus repair and transplantation procedures. In: Noyes FR, Barber-Westin SD (eds) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 806–817
Hertel P, Behrend H, Cierpinski T et al (2005) ACL reconstruction using bone-patellar tendon-bone press-fit fixation: 10-year clinical results. Knee Surg Sports Traumatol Arthrosc 13(4):248–255
Higuchi H, Shirakura K, Kimura M et al (2006) Changes in biochemical parameters after anterior cruciate ligament injury. Int Orthop 30(1):43–47
Hui C, Salmon LJ, Kok A et al (2011) Fifteen-year outcome of endoscopic anterior cruciate ligament reconstruction with patellar tendon autograft for “isolated” anterior cruciate ligament tear. Am J Sports Med 39(1):89–98
Johnson DL, Urban WP, Caborn DNM et al (1998) Articular cartilage changes seen with magnetic resonance imaging-detected bone bruises associated with acute anterior cruciate ligament rupture. Am J Sports Med 26(3):409–414
Johnson KL, Bealle DP, Brand JC et al (2000) The effect of a geographic lateral bone bruise on knee inflammation after acute anterior cruciate ligament rupture. Am J Sports Med 28(2):152–155
Jomha NM, Pinczewski LA, Clingeleffer A et al (1999) Arthroscopic reconstruction of the anterior cruciate ligament with patellar-tendon autograft and interference screw fixation. The results at seven years. J Bone Joint Surg Br 81(5):775–779
Jonsson H, Riklund-Ahlstrom K, Lind J (2004) Positive pivot shift after ACL reconstruction predicts later osteoarthrosis: 63 patients followed 5–9 years after surgery. Acta Orthop Scand 75(5):594–599
Kamath GV, Redfern JC, Greis PE et al (2011) Revision anterior cruciate ligament reconstruction. Am J Sports Med 39(1):199–217
Keays SL, Bullock-Saxton JE, Keays AC et al (2007) A 6-year follow-up of the effect of graft site on strength, stability, range of motion, function, and joint degeneration after anterior cruciate ligament reconstruction: patellar tendon versus semitendinosus and Gracilis tendon graft. Am J Sports Med 35(5):729–739
Kessler MA, Behrend H, Henz S et al (2008) Function, osteoarthritis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment. Knee Surg Sports Traumatol Arthrosc 16(5):442–448
Lahm A, Erggelet C, Steinwachs M et al (1998) Articular and osseous lesions in recent ligament tears: arthroscopic changes compared with magnetic resonance imaging findings. Arthroscopy 14(6):597–604
Lee JH, Ort T, Ma K et al (2009) Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro. Osteoarthritis Cartilage 17(5):613–620
Li RT, Lorenz S, Xu Y et al (2011) Predictors of radiographic knee osteoarthritis after anterior cruciate ligament reconstruction. Am J Sports Med 39(12):2595–2603
Lohmander LS, Saxne T, Heinegard DK (1994) Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis. Ann Rheum Dis 53(1):8–13
Lohmander LS, Atley LM, Pietka TA et al (2003) The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 48(11):3130–3139
Marchant BG, Noyes FR, Barber-Westin SD et al (2010) Prevalence of nonanatomical graft placement in a series of failed anterior cruciate ligament reconstructions. Am J Sports Med 38(10):1987–1996
Mihelic R, Jurdana H, Jotanovic Z et al (2011) Long-term results of anterior cruciate ligament reconstruction: a comparison with non-operative treatment with a follow-up of 17–20 years. Int Orthop 35(7): 1093–1097
Myklebust G, Holm I, Maehlum S et al (2003) Clinical, functional, and radiologic outcome in team handball players 6 to 11 years after anterior cruciate ligament injury: a follow-up study. Am J Sports Med 31(6):981–989
Myklebust G, Bahr R (2005) Return to play guidelines after anterior cruciate ligament surgery. Br J Sports Med 39(3):127–131
Nakamae A, Engebretsen L, Bahr R et al (2006) Natural history of bone bruises after acute knee injury: clinical outcome and histopathological findings. Knee Surg Sports Traumatol Arthrosc 14(12):1252–1258
Nakata K, Shino K, Horibe S et al (2008) Arthroscopic anterior cruciate ligament reconstruction using fresh-frozen bone plug-free allogeneic tendons: 10-year follow-up. Arthroscopy 24(3):285–291
Nishimori M, Deie M, Adachi N et al (2008) Articular cartilage injury of the posterior lateral tibial plateau associated with acute anterior cruciate ligament injury. Knee Surg Sports Traumatol Arthrosc 16(3):270–274
Noyes FR, Bassett RW, Grood ES (1980) Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. J Bone Joint Surg Am 62(5):687–695, 757
Noyes FR, Barber SD, Simon R (1993) High tibial osteotomy and ligament reconstruction in varus angulated, anterior cruciate ligament-deficient knees. A two- to seven-year follow-up study. Am J Sports Med 21(1):2–12
Noyes FR, Barber-Westin SD (1997) A comparison of results in acute and chronic anterior cruciate ligament ruptures of arthroscopically assisted autogenous patellar tendon reconstruction. Am J Sports Med 25(4):460–471
Noyes FR, Barber-Westin SD (2000) Arthroscopic repair of meniscus tears extending into the avascular zone with or without anterior cruciate ligament reconstruction in patients 40 years of age and older. Arthroscopy 16(8):822–829
Noyes FR, Barber-Westin SD, Hewett TE (2000) High tibial osteotomy and ligament reconstruction for varus angulated anterior cruciate ligament-deficient knees. Am J Sports Med 28(3):282–296
Noyes FR, Barber-Westin SD (2001) Revision anterior cruciate surgery with use of bone-patellar tendon-bone autogenous grafts. J Bone Joint Surg Am 83-A(8):1131–1143
Noyes FR, Barber-Westin SD (2001) Revision anterior cruciate ligament reconstruction: report of 11-year experience and results in 114 consecutive patients. Instr Course Lect 50:451–461
Noyes FR, Barber-Westin SD (2002) Arthroscopic repair of meniscal tears extending into the avascular zone in patients younger than twenty years of age. Am J Sports Med 30(4):589–600
Noyes FR, Barber-Westin SD (2006) Anterior cruciate ligament revision reconstruction: results using a quadriceps tendon-patellar bone autograft. Am J Sports Med 34(4):553–564
Noyes FR, Barber-Westin SD, Albright JC (2006) An analysis of the causes of failure in 57 consecutive posterolateral operative procedures. Am J Sports Med 34(9):1419–1430
Noyes FR, Barber-Westin SD (2009) Primary, double, and triple varus knee syndromes: diagnosis, osteotomy techniques, and clinical outcomes. In: Noyes FR (ed) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 821–895
Noyes FR, Barber-Westin SD (2009) Anterior cruciate ligament primary and revision reconstruction: diagnosis, operative techniques, and clinical outcomes. In: Noyes FR (ed) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 140–228
Noyes FR, Barber-Westin SD (2009) Meniscus tears: diagnosis, repair techniques, and clinical outcomes. In: Noyes FR, Barber-Westin SD (eds) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 733–771
Noyes FR, Grood ES (2009) Knee ligament function and failure. In: Noyes FR (ed) Noyes’ knee disorders: surgery, rehabilitation, clinical outcomes. Saunders, Philadelphia, pp 89–113
Noyes FR, Barber-Westin SD (2010) Management of special problems associated with knee menisci: repair of complex and avascular tears and meniscus transplantation. In: Egol KA (ed) Instructional course lectures, vol 60. AAOS, Rosemont
Noyes FR, Chen RC, Barber-Westin SD et al (2011) Greater than 10-year results of red-white longitudinal meniscal repairs in patients 20 years of age or younger. Am J Sports Med 39(5):1008–1017
Noyes FR, Barber-Westin SD (2012) Treatment of meniscus tears during anterior cruciate ligament reconstruction. Arthroscopy 28(1):123–130
Noyes FR, Heckmann TP, Barber-Westin SD (2012) Meniscus repair and transplantation: a comprehensive update. J Orthop Sports Phys Ther 42(3):274–290
O’Neill DB (2001) Arthroscopically assisted reconstruction of the anterior cruciate ligament. A follow-up report. J Bone Joint Surg Am 83-A(9):1329–1332
Pinczewski LA, Lyman J, Salmon LJ et al (2007) A 10-year comparison of anterior cruciate ligament reconstructions with hamstring tendon and patellar tendon autograft: a controlled, prospective trial. Am J Sports Med 35(4):564–574
Potter HG (2011) Commentary on an article by Richard B. Frobell, PhD: change in cartilage thickness, posttraumatic bone marrow lesions, and joint fluid volumes after acute acl disruption. a two-year prospective MRI study of sixty-one subjects. J Bone Joint Surg Am 93(12):e71 (71–72)
Potter HG, Jain SK, Ma Y et al (2012) Cartilage injury after acute, isolated anterior cruciate ligament tear: immediate and longitudinal effect with clinical/MRI follow-up. Am J Sports Med 40(2):276–285
Roe J, Pinczewski LA, Russell VJ et al (2005) A 7-year follow-up of patellar tendon and hamstring tendon grafts for arthroscopic anterior cruciate ligament reconstruction: differences and similarities. Am J Sports Med 33(9):1337–1345
Rosen MA, Jackson DW, Berger PE (1991) Occult osseous lesions documented by magnetic resonance imaging associated with anterior cruciate ligament ruptures. Arthroscopy 7(1):45–51
Rubman MH, Noyes FR, Barber-Westin SD (1998) Arthroscopic repair of meniscal tears that extend into the avascular zone. A review of 198 single and complex tears. Am J Sports Med 26(1):87–95
Sajovic M, Strahovnik A, Komadina R et al (2008) The effect of graft choice on functional outcome in anterior cruciate ligament reconstruction. Int Orthop 32(4):473–478
Salmon LJ, Russell VJ, Refshauge K et al (2006) Long-term outcome of endoscopic anterior cruciate ligament reconstruction with patellar tendon autograft: minimum 13-year review. Am J Sports Med 34(5):721–732
Shelbourne KD, Gray T (2000) Results of anterior cruciate ligament reconstruction based on meniscus and articular cartilage status at the time of surgery. Five- to fifteen-year evaluations. Am J Sports Med 28(4):446–452
Shelbourne KD, Gray T, Haro M (2009) Incidence of subsequent injury to either knee within 5 years after anterior cruciate ligament reconstruction with patellar tendon autograft. Am J Sports Med 37(2):246–251
Speer KP, Spritzer CE, Bassett FH et al (1992) Osseous injury associated with acute tears of the anterior cruciate ligament. Am J Sports Med 20(4):382–389
Spindler KP, Schils JP, Bergfeld JA et al (1993) Prospective study of osseous, articular, and meniscal lesions in recent anterior cruciate ligament tears by magnetic resonance imaging and arthroscopy. Am J Sports Med 21(4):551–557
Stein LN, Fischer DA, Fritts HM et al (1995) Occult osseous lesions associated with anterior cruciate ligament tears. Clin Orthop Relat Res 313:187–193
Stein T, Mehling AP, Welsch F et al (2010) Long-term outcome after arthroscopic meniscal repair versus arthroscopic partial meniscectomy for traumatic meniscal tears. Am J Sports Med 38(8):1542–1548
Stevenson WW 3rd, Johnson DL (2007) “Vertical grafts”: a common reason for functional failure after ACL reconstruction. Orthopedics 30(3):206–209
Theologis AA, Kuo D, Cheng J et al (2011) Evaluation of bone bruises and associated cartilage in anterior cruciate ligament-injured and -reconstructed knees using quantitative t(1rho) magnetic resonance imaging: 1-year cohort study. Arthroscopy 27(1):65–76
Tiderius CJ, Olsson LE, Nyquist F et al (2005) Cartilage glycosaminoglycan loss in the acute phase after an anterior cruciate ligament injury: delayed gadolinium-enhanced magnetic resonance imaging of cartilage and synovial fluid analysis. Arthritis Rheum 52(1):120–127
Trojani C, Sbihi A, Djian P et al (2010) Causes for failure of ACL reconstruction and influence of meniscectomies after revision. Knee Surg Sports Traumatol Arthrosc 19(2):196–201
Vellet AD, Marks PH, Fowler PJ et al (1991) Occult posttraumatic osteochondral lesions of the knee: prevalence, classification, and short-term sequelae evaluated with MR imaging. Radiology 178(1):271–276
von Porat A, Roos EM, Roos H (2004) High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis 63(3):269–273
Wright RW, Dunn WR, Amendola A et al (2007) Risk of tearing the intact anterior cruciate ligament in the contralateral knee and rupturing the anterior cruciate ligament graft during the first 2 years after anterior cruciate ligament reconstruction: a prospective MOON cohort study. Am J Sports Med 35(7):1131–1134
Wu WH, Hackett T, Richmond JC (2002) Effects of meniscal and articular surface status on knee stability, function, and symptoms after anterior cruciate ligament reconstruction: a long-term prospective study. Am J Sports Med 30(6):845–850
Yoon JP, Chang CB, Yoo JH et al (2010) Correlation of magnetic resonance imaging findings with the chronicity of an anterior cruciate ligament tear. J Bone Joint Surg Am 92(2):353–360
Yoon KH, Yoo JH, Kim KI (2011) Bone contusion and associated meniscal and medial collateral ligament injury in patients with anterior cruciate ligament rupture. J Bone Joint Surg Am 93A(16):1510–1518
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Noyes, F.R., Barber-Westin, S.D. (2012). ACL Reconstruction: Chondroprotective Effects, Risks of Reinjury. In: Noyes, F., Barber-Westin, S. (eds) ACL Injuries in the Female Athlete. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32592-2_3
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