Abstract
During attempted investigations into the Pd(II) catalysed aminocarbonylations of alkenes (Chap. 2) conditions were found to from pyrimidiones in low yields. The reaction is stoichiometric with respect to the palladium. Unfortunately efforts to render the reaction catalytic were unsuccessful. The reaction is substrate specific with rates of β-hydride elimination of the palladated intermediate critical to reactivity. Unfortunately the analogous reaction with methanol failed to furnish β-amino acid derivatives (Scheme 6.1).
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Hutchby, M. (2013). Conclusions and Future Work. In: Novel Synthetic Chemistry of Ureas and Amides. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32051-4_6
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DOI: https://doi.org/10.1007/978-3-642-32051-4_6
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