Abstract
Neuronal probes can be defined as biohybrid entities where the probes and nerve cells establish a close physical interaction for communicating in one or both directions. During the last decade neuronal probe technology has seen an exploded development. This paper presents newly developed chip–based CyberRat probes for enhanced signal transmission from nerve cells to chip or from chip to nerve cells with an emphasis on in−vivo interfacing, either in terms of signal−to−noise ratio or of spatiotemporal resolution. The oxide−insulated chips featuring large−scale and high−resolution arrays of stimulation and recording elements are a promising technology for high spatiotemporal resolution biohybrid devices, as recently demonstrated by recordings obtained from hippocampal slices and brain cortex in implanted animals. Finally, we report on SigMate, an in−house comprehensive automated tool for processing and analysis of acquired signals by such large scale biohybrid devices.
All authors contributed equally to the work.
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Vassanelli, S., Felderer, F., Mahmud, M., Maschietto, M., Girardi, S. (2012). CyberRat Probes: High-Resolution Biohybrid Devices for Probing the Brain. In: Prescott, T.J., Lepora, N.F., Mura, A., Verschure, P.F.M.J. (eds) Biomimetic and Biohybrid Systems. Living Machines 2012. Lecture Notes in Computer Science(), vol 7375. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31525-1_24
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DOI: https://doi.org/10.1007/978-3-642-31525-1_24
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