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Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus pp 1–22Cite as

Genome Organization of Peste des Petits Ruminants Virus

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Abstract

Peste des Petits Ruminants (PPR) virions are enveloped, pleomorphic particles containing a genome of single stranded RNA that is enclosed in a ribonucleoprotein core. The PPRV genome is 15,948 nucleotides (nts) long, which is the longest of all the morbillivirus members except for a recently described feline morbillivirus, which is revealed to be 16,050 bases long due to unusually long 5′ trailer sequence. The genome of PPRV encodes for eight genes in the order 3′-N–P/C/V-M-F-HN-L-5′. The mean diameter of PPR virions (400–500 nm) is slightly larger than rinderpest virus (RPV) (300 nm). As a typical feature for all members of the genus morbillivirus, the PPRV genome length follows the “rule of six”, but carries a certain degree of flexibility by accommodation of +1, +2 and −1 nts, which is a unique property of PPRV among morbilliviruses. In this chapter, all of the known features of the PPRV genome structure and biology are discussed. Additionally, all of the structural and nonstructural proteins are described comprehensively.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Veterinary, Swedish University of Agricultural Sciences (SLU), Ulls väg 2B, Uppsala, 751 89, Sweden

    Muhammad Munir & Mikael Berg

  2. Joint Research and Development Unit for Virology of SVA and SLU, Swedish University of Agricultural Sciences, Ulls väg 2B, Uppsala, 751 89, Sweden

    Siamak Zohari

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  1. Muhammad Munir
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Munir, M., Zohari, S., Berg, M. (2013). Genome Organization of Peste des Petits Ruminants Virus. In: Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus. SpringerBriefs in Animal Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31451-3_1

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