Abstract
Californium-252 sources are used in several cancer institutions for clinical interstitial or intracavitary neutron brachytherapy. The dose deposited from the fast neutron and gamma irradiation components from a Cf-252 source is the main therapeutic agent for these treatment techniques. The symmetrical, isotropic nature of the dose distribution and the relatively small number of available source positions for the case of high dose rate intracavitary brachytherapy make it difficult to obtain good conformality of irregularly shaped targets. Furthermore, the rapid dose fall-off from a brachytherapy source often compromises the dose to the areas of potential tumour micro-invasion. Administration of Gd-157 pellets (seeds or needles) to the planned position alter the primary absorbed dose distribution of the high dose rate Cf-252 source to best conform the irregularly shaped tumour and sufficiently irradiate areas of micro-invasion. The thermal neutron fluence from a Cf-252 source is often used as an external source for neutron induced brachytherapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Fields PR et al (1956) Transplutonium elements in thermonuclear test debris. Phys Rev 102:180–182
Knauer JB, Alexander CW, Bigelow JE (1991) Cf-252 properties, production, source fabrication and procurement. Nucl Sci Appl 4:3–17
Browne E, Firestone RB, Shirley VS (eds) (1986) Table of radioactive isotopes. Wiley-Interscience, New York, pp 249–1 – 254–1
Axton NE (1987) Intercomparison of neutron source emission rates (1979–1984). Metrologia 23:129–144
Grundl J, Eisenhauer C (1975) Fission rate measurements for materials neutron dosimetry in reactor environments. In: Proceedings of the first ASTM-EURATOM symposium on reactor dosimetry, Petten, 1975, pp 425–454
Anderson LL (1986) Cf-252 physics and dosimetry. Nucl Sci Appl 2:273–282
Zyb A (ed) (1996) Effects of Cf-252 gamma-neutron irradiation. Energoatomizdat, Moscow
Maruyama Y (1984) Cf-252 neutron brachytherapy an advance for bulky localized cancer therapy. Nucl Sci Appl 1:677–748
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Miller, A. (2012). Californium-252 as a Neutron Source for BNCT. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-31334-9_5
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31333-2
Online ISBN: 978-3-642-31334-9
eBook Packages: MedicineMedicine (R0)