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Application of Neutron Capture Therapy for Locally Recurrent Breast Cancer

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Neutron Capture Therapy

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Abstract

Locally recurrent and advanced breast cancer (including inflammatory breast cancer-like type) is one of the most difficult conditions to cure, and new therapies are needed. If sufficient boron compound can be targeted to the tumor, boron neutron capture therapy (BNCT) can be applied to locally recurrent and advanced breast cancer. In this study, we performed preliminary dosimetry with a phantom model of the mammary gland at the Kyoto University Research Reactor (KUR) and feasibility dosimetry with JCDS at the JRR4 reactor at the Japan Atomic Research Institute.

We performed preliminary dosimetry of a phantom model of the mammary gland with thermal neutron irradiation (OO-0011 mode) on LiF collimation at KUR. The thermal neutron flux was 5.16 E + 08 cm-2 s−1 at the surface of the phantom. The blood boron concentration is estimated to be 30 ppm, and the tumor boron concentration to be 90 ppm, according to which the tumor/blood ratio is 3 and the skin/blood ratio is 1.2. The tumor RBE dose is estimated to be 47 Gy/h, and the skin RBE dose is 12.4 Gy/h.

For recurrent breast cancer, we performed a feasibility estimation of a 3D construction of the tumor according to the MRI imaging of a patient with epithermal neutron mode at JRR4. The blood-boron concentration (ppm) and tumor/normal tissue ratio are estimated to be 24 and 3.5, respectively. The skin RBE dose is restricted to 10 Gy/h. The maximum tumor RBE dose, minimum tumor RBE dose, and mean tumor RBE dose are 64.3, 16.6, and 46.5 Gy, respectively, in half hour irradiation.

In this study, we showed the possibility to apply BNCT to locally recurrent and advanced breast cancer. We can irradiate tumors as selectively and safety as possible, reducing the effects on neighboring healthy tissues.

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Authors and Affiliations

  1. Department of Nuclear Engineering and Management, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Hironobu Yanagie

  2. Cooperative Unit of Medicine and Engineering, The University of Tokyo Hospital, Tokyo, Japan

    Hironobu Yanagie

  3. Department of Surgery and Gastroenterology, Kyorindo Clinic, Kanagawa, Japan

    Hironobu Yanagie

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  1. Hironobu Yanagie
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Correspondence to Hironobu Yanagie .

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Editors and Affiliations

  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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Yanagie, H. (2012). Application of Neutron Capture Therapy for Locally Recurrent Breast Cancer. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_27

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  • DOI: https://doi.org/10.1007/978-3-642-31334-9_27

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31333-2

  • Online ISBN: 978-3-642-31334-9

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