Abstract
Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles yielded up by 10B(n, alpha)7Li reactions. However, there are unfavorable radiation beams such as gamma ray and high-energy neutron beams. To improve the clinical results, the efforts have concentrated on escalating the dose of alpha particles and recoiling lthium-7(7Li) yielded up by 10B(n, alpha)7Li reaction in the clinical target volume. We evaluated the clinical outcomes of 183 patients with malignant brain tumors treated by BNCT since 1968. We demonstrate the relationship between boron concentration in tumor tissue, radiation dose, and clinical outcomes.
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© 2012 Springer-Verlag Berlin Heidelberg
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Nakagawa, Y., Kageji, T. (2012). Tolerance of Healthy Tissues and Ideal Radiation Dose on BNCT. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_18
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DOI: https://doi.org/10.1007/978-3-642-31334-9_18
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