Abstract
A method is presented which quantifies the radiodensity of lesions in projection images, providing a diagnostic indicator to better inform the decisions of both human readers and computer algorithms. The models of image formation underlying the Standard Attenuation Rate (SAR) are used to facilitate the forward simulation of the appearance of a lesion in a breast. By forming hypotheses, informed from measurements on the acquired image, virtual 3D scenes are constructed which predict the size, position and radiodensity of a suspect lesion and the surrounding breast tissue. Comparisons between simulations of this scene, and the acquired image enable both the refinement of the hypothesis, and the assessment of the likelihood of the hypothesis being correct. In the event of a high likelihood of correctness, the hypothesised lesion informs diagnosis. The application of the method to a patient image containing a cyst shows it has an attenuation corresponding to water (SAR 1.246), and an invasive carcinoma which is considerably denser at SAR 2.27. Thus the technique yields a quantitative radiodensity measure for discrimination in diagnostic decision making.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Roman, M., Fau-Sala, R., et al.: Effect of protocol-related variables and women’s characteristics on the cumulative false-positive risk in breast cancer screening, 20111222
Tromans, C.: DPhil Thesis: Measuring Breast Density from X-Ray Mammograms. DPhil Thesis, Engineering Science. Oxford University (October 2006)
Tromans, C., Brady, M.: An Alternative Approach to Measuring Volumetric Mammographic Breast Density. In: Astley, S.M., Brady, M., Rose, C., Zwiggelaar, R. (eds.) IWDM 2006. LNCS, vol. 4046, pp. 26–33. Springer, Heidelberg (2006)
Tromans, C.E., Brady, S.M.: The Standard Attenuation Rate for Quantitative Mammography. In: MartÃ, J., Oliver, A., Freixenet, J., MartÃ, R. (eds.) IWDM 2010. LNCS, vol. 6136, pp. 561–568. Springer, Heidelberg (2010)
Hammerstein, G.R., et al.: Absorbed radiation dose in mammography. Radiology 130, 485–491 (1979)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Tromans, C., van Schie, G., Karssemeijer, N., Brady, S.M. (2012). A Hypothesis-Test Framework for Quantitative Lesion Detection and Diagnosis. In: Maidment, A.D.A., Bakic, P.R., Gavenonis, S. (eds) Breast Imaging. IWDM 2012. Lecture Notes in Computer Science, vol 7361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31271-7_59
Download citation
DOI: https://doi.org/10.1007/978-3-642-31271-7_59
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31270-0
Online ISBN: 978-3-642-31271-7
eBook Packages: Computer ScienceComputer Science (R0)