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Sex Cord-Stromal Tumors

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Gynecological Imaging

Abstract

It comprises neoplasms that contain cells of the follicular wall (granulosa cells, theca cells, and their luteinized derivates), as well as fibroblasts of stromal origin, singly or in various combinations and in varying degrees of differentiation [1, 2]. More rarely, these tumors arise from Leydig cells mainly located in the hilus of the ovary. Uncommonly, tumors can contain Sertoli cells, (which are not present in the normal ovary) isolated or less exceptionally associated with other cells types mentioned above.

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References

  1. Gee DC, Russel P (1981) The pathological assessment of ovarian neoplasms. IV. The sex cord stromal tumors. Pathology 13:235–255

    Article  PubMed  CAS  Google Scholar 

  2. Young RH, Scully RE (1994) Sex cord-stromal, steroid cell and other ­ovarian tumors with endocrine, paraendocrine and paraneoplastic manifestations. In: Kurman RJ (ed) Blaustein’s pathology of the female genital tract, 4th edn. Springer, New York, pp 783–847

    Chapter  Google Scholar 

  3. Scully RE, Young RH, Clement PB (1998) Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament, 3rd edn. Armed Force Institute of Pathology, Washington, DC, pp 169–188

    Google Scholar 

  4. Bjorkholm E, Silfversward C (1980) Theca-cell tumors. Clinical features and prognosis. Acta Radiol Oncol 19:241–244

    Article  PubMed  CAS  Google Scholar 

  5. Dockerty MB, Masson JC (1944) Ovarian fibromas: a clinical and pathologic study of two hundred and eighty-three cases. Am J Obstet Gynecol 47:741–752

    Google Scholar 

  6. Zhang J, Young RH, Arseneau J, Scully RE (1982) Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors). A clinicopathological analysis of fifty cases. Int J Gynecol Pathol 1:270–285

    Article  PubMed  CAS  Google Scholar 

  7. Young RH, Clement PB, Scully RE (1988) Calcified thecomas in young women. A report of four cases. Int J Gynecol Pathol 7:343–350

    Article  PubMed  CAS  Google Scholar 

  8. Bazot M, Ghossain MA, Buy JN et al (1993) Fibrothecomas of the ovary: CT and US findings. J Comput Assist Tomogr 17:754–759

    Article  PubMed  CAS  Google Scholar 

  9. Atri M, Nazarnia S, Bret PM, Aldis AE, Kintzen G, Reinhold CE (1994) Endovaginal sonographic appearance of benign ovarian masses. Radio­graphics 14:747–760

    PubMed  CAS  Google Scholar 

  10. Stephenson WM, Laing FC (1985) Sonography of ovarian fibromas. AJR 144:1239–1240

    Article  PubMed  CAS  Google Scholar 

  11. Buy JN, Ghossain MA, Hugol D et al (1996) Characterization of adnexal masses: combination of color doppler and conventional sonography compared with spectral Doppler analysis alone and conventional sonography alone. AJR 166:385–393

    Article  PubMed  CAS  Google Scholar 

  12. Conte M, Guariglia L, Benedetti Panici P et al (1991) Ovarian fibrothecomas: sonographic and histologic findings. Gynecol Obstet Invest 32:51–54

    Article  PubMed  CAS  Google Scholar 

  13. Weinreb JC, Barkoff ND, Megibow A, Demopoulos R (1990) The value of MR imaging in distinguishing leiomyomas from other solid pelvic masses when sonography is indeterminate. AJR 154:295–299

    Article  PubMed  CAS  Google Scholar 

  14. Troiano RN, Lazzarini KM, Scoutt LM et al (1997) Fibroma and fibrothecoma of the ovary: MR imaging findings. Radiology 204:795–798

    PubMed  CAS  Google Scholar 

  15. Scoutt L, Mc Carthy S, Lange R, Bourque A, Schwartz P (1994) MR evaluation of clinically suspected adnexal masses. J Comput Assist Tomogr 18:609–618

    Article  PubMed  CAS  Google Scholar 

  16. Athey PA, Malone RS (1987) Sonography of ovarian fibromas/thecomas. J Ultrasound Med 6:431–436

    PubMed  CAS  Google Scholar 

  17. Chechia A, Koubaa A, Makhlouf T et al (2001) Ovarian fibrothecal tumors. A propos of 12 cases. Gynecol Obstet Fertil 29:349–353

    Article  PubMed  CAS  Google Scholar 

  18. Jones HW, Jones GS (eds) (1981) Novak’s textbook of gynecology. Williams and Wilkins, Baltimore, pp 582–584

    Google Scholar 

  19. Droegemueller W, Herbst AL, Mishell DR, Sterchever MA (eds) (1987) Comprehensive gynecology. CV Mosby, St. Louis, pp 479–482

    Google Scholar 

  20. Meigs JV (1954) Fibromas of the ovary with ascites and hydrothorax-Meig’s syndrome. Am J Obstet Gynecol 67:962–987

    PubMed  CAS  Google Scholar 

  21. Meigs JV, Cass JW (1937) Fibroma of the ovary with ascites and hydrothorax: with a report of seven cases. Am J Obstet Gynecol 33:249–267

    Google Scholar 

  22. Bierman SM, Reuter KL, Hunter RE (1990) Meigs syndrome and ovarian fibroma: CT findings. J Comput Assist Tomog 14:833–834

    Article  CAS  Google Scholar 

  23. Massoni F, Carbillon L, Azria E, Uzan M (2001) Demons-Meigs syndrome: a propos of one case. Gynecol Obstet Fertil 29:905–907

    Google Scholar 

  24. Laufer L, Barki Y, Mordechai Y, Maor E, Mares A (1996) Ovarian fibroma in a prepubertal girl. Pediatr Radiol 26:40–42

    Article  PubMed  CAS  Google Scholar 

  25. Tytle T, Rosin D (1984) Bilateral calcified ovarian fibromas. South Med J 77:1178–1180

    Article  PubMed  CAS  Google Scholar 

  26. Diakoumatis E, Vieux U, Seife B (1984) Sonographic demonstration of thecoma: report of two cases. Am J Obstet Gynecol 150:787–788

    Google Scholar 

  27. Yaghoobian J, Pinck RL (1983) Ultrasound findings in thecoma of the ovary. J Clin Ultrasound 11:91–93

    Article  PubMed  CAS  Google Scholar 

  28. Williams LL, Fleisher AC, Jones HW 3rd (1992) Transvaginal color Doppler sonography and CA-125 elevation in a patient with ovarian thecoma and ascites. Gynecol Oncol 46:115–118

    Article  PubMed  CAS  Google Scholar 

  29. Togashi K (1993) MRI of the female pelvis. Igaku-Shoin, Tokyo, pp 227–279

    Google Scholar 

  30. Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B (1998) Sex cord-stromal and steroid cell tumors of the ovary. Radiographics 18:1523–1546

    PubMed  CAS  Google Scholar 

  31. Takemori M, Nishimura R, Hasegawa K (2000) Ovarian thecoma with ascites and high serum levels of CA125. Arch Gynecol Obstet 264:42–44

    Article  PubMed  CAS  Google Scholar 

  32. Clement PB, Young RH, Hanna W, Scully RE (1994) Sclerosing peritonitis associated with luteinized thecomas of the ovary. A clinicopathological analysis of six cases. Am J Surg Pathol 18:1–13

    Article  PubMed  CAS  Google Scholar 

  33. Khan EM, Pandey R (1994) Sarcoma-like ovarian nodules associated with retractile mesenteritis and retroperitoneal fibrosis. Histopathology 24:276–278

    Article  PubMed  CAS  Google Scholar 

  34. Reginella RF, Sumkin JH (1996) Sclerosing peritonitis associated with luteinized thecomas. AJR 167:512–513

    Article  PubMed  CAS  Google Scholar 

  35. Chalvardjian A, Scully RE (1973) Sclerosing stromal tumors of the ovary. Cancer 31:664–670

    Article  PubMed  CAS  Google Scholar 

  36. Ihara N, Togashi K, Todo G et al (1999) Sclerosing stromal tumor of the ovary: MRI. J Comput Assist Tomogr 23:555–557

    Article  PubMed  CAS  Google Scholar 

  37. Joja I, Okuno K, Tsunoda M et al (2001) Sclerosing stromal tumor of the ovary: US, MR, and dynamic MR findings. J Comput Assist Tomogr 25:201–206

    Article  PubMed  CAS  Google Scholar 

  38. Kawauchi S, Tsuji T, Kaku T et al (1998) Sclerosing stromal tumor of the ovary: a clinicopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis with special reference to its vasculature. Am J Surg Pathol 22:83–92

    Article  PubMed  CAS  Google Scholar 

  39. Tang MY, Liu TH (1982) Ovarian sclerosing stromal tumors. Clinicopathologic study of 10 cases. Clin Med J 95:186–190

    CAS  Google Scholar 

  40. Lee MS, Cho HC, Lee YH, Hong SR (2001) Ovarian sclerosing stromal tumors: gray scale and color Doppler sonographic findings. J Ultrasound Med 20:413–417

    PubMed  CAS  Google Scholar 

  41. Torricelli P, Caruso Lombardi A, Boselli F, Rossi G (2002) Sclerosing stromal tumor of the ovary: US, CT, and MRI findings. Abdom Imaging 27:588–591

    Article  PubMed  CAS  Google Scholar 

  42. Matsubayashi R, Matsuo Y, Doi J, Kudo S, Matsuguchi K, Sugimori H (1999) Sclerosing stromal tumor of the ovary: radiologic findings. Eur Radiol 9:1335–1338

    Article  PubMed  CAS  Google Scholar 

  43. Prat J, Scully RE (1981) Cellular fibromas and fibrosarcomas of the ovary: a comparative clinico-pathologic analysis of seventeen cases. Cancer 47:2663–2670

    Article  PubMed  CAS  Google Scholar 

  44. Outwater EK, Seligman ES, Talerman A, Dunton C (1997) Ovarian fibromas and cystadenofibromas: MRI features of fibrous component. JMRI 7:465–471

    Article  PubMed  CAS  Google Scholar 

  45. Bjorkholm E (1980) Granulosa cell tumors: a comparison of survival in patients and matched controls. Am J Obstet Gynecol 138:329–331

    PubMed  CAS  Google Scholar 

  46. Stenwig JT, Hazekamp JT, Beecham JB (1979) Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term ­follow-up. Gynecol Oncol 7:135–152

    Article  Google Scholar 

  47. Nakashima N, Young RH, Scully RE (1984) Androgenic granulosa cell tumors of the ovary. A clinicopathological analysis of seventeen cases and review of the literature. Arch Path Lab Med 108:786–791

    PubMed  CAS  Google Scholar 

  48. Norris HJ, Taylor HB (1968) Prognosis of granulosa-theca tumors of the ovary. Cancer 21:255–263

    Article  PubMed  CAS  Google Scholar 

  49. Gusberg SB, Kardon P (1967) Proliferative endometrial response to ­theca-granulosa cell tumors. Am J Obstet Gynecol 111:633–643

    Google Scholar 

  50. Young RH, Dickersin GR, Scully RE (1984) Juvenile granulosa cell tumor of the ovary. A clinicopathologic analysis of 125 cases. Am J Surg Pathol 8:575–596

    Article  PubMed  CAS  Google Scholar 

  51. Zaloudek C, Norris HJ (1982) Granulosa tumors of the ovary in children. A clinical and pathological study of 32 cases. Am J Surg Pathol 6:503–512

    Article  PubMed  CAS  Google Scholar 

  52. Kim SH, Kim SH (2002) Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. J Comput Assist Tomogr 26:756–761

    Article  PubMed  Google Scholar 

  53. Sugimura K (1993) MRI diagnosis of the ovary (Japanese). In: Sugimura K (ed) MRI diagnosis of pelvis. Igaku-Shoin, Tokyo, pp 88–132

    Google Scholar 

  54. Jabra AA, Fishman EK, Taylor GA (1993) Primary ovarian tumors in the pediatric patient: CT evaluation. Clin Imaging 17:199–203

    Article  PubMed  CAS  Google Scholar 

  55. Ko SF, Wan YL, Ng SH, Lee TY, Lin JW, Chen WJ, Kung FT, Tsai CC (1999) Adult ovarian granulosa cell tumors: spectrum of sonographic and CT findings with pathologic correlation. AJR 172:1227–1233

    Article  PubMed  CAS  Google Scholar 

  56. Melemed A, Desouky S, Allen DB, Gilbert-Barness E (1993) Juvenile granulosa cell tumor. Am J Dis Child 147:209–210

    PubMed  CAS  Google Scholar 

  57. Bjorkholm E, Pettersson F (1980) Granulosa-cell and theca cell tumors. The clinical picture and long term outcome for the Radiumhemmet series. Acta Obstet Gynecol Scand 59:361–365

    Article  PubMed  CAS  Google Scholar 

  58. Bjorkholm E, Silversward C (1981) Prognostic factors in granulosa cell tumors. Gynecol Oncol 11:261–274

    Article  PubMed  CAS  Google Scholar 

  59. Thorvinger B, Samuelsson S, Skyaerris J (1987) CT of malignant ovarian disease. Acta Radiol 28:739–742

    Article  PubMed  CAS  Google Scholar 

  60. Margolin KA, Pak HY, Esensten ML, Doroshow JH (1985) Hepatic metastases in granulosa cell tumor of the ovary. Cancer 56:691–695

    Article  PubMed  CAS  Google Scholar 

  61. Chew DKW, Schutzer RW, Domer G, Jaloudi MA, Rogers AM (2003) Splenic rupture from metastatic granulosa cell tumor 29 years after curative resection: case report and review of the literature. Am Surg 69:106–108

    PubMed  Google Scholar 

  62. Scully RE, Young RH, Clement PB (1998) Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament, 3rd edn. Armed Force Institute of Pathology, Washington, DC, pp 227–238

    Google Scholar 

  63. Novak ER, Long JH (1965) Arrhenoblastoma of the ovary. A review of the ovarian tumor registry. Am J Obstet Gynecol 92:1082–1093

    PubMed  CAS  Google Scholar 

  64. Wong IL, Lobo RA (1996) Reproductive endocrinology, surgery, and technology, 1st edn. Lippincott-Raven, Philadelphia, pp 1571–1598

    Google Scholar 

  65. Young RH, Scully RE (1985) Ovarian sertoli-leydig cell tumors. A clinico-pathological analysis of 207 cases. Am J Surg Pathol 9:543–569

    Article  PubMed  CAS  Google Scholar 

  66. Gagnon S, Tetu B, Silva EG, McCaughey WT (1989) Frequency of alpha-fetoprotein production by Sertoli-Leydig cell tumors of the ovary: an immunohistochemical study of eight cases. Mod Pathol 2:63–67

    PubMed  CAS  Google Scholar 

  67. Young RH, Perez-Atayde AR, Scully RE (1984) Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Am J Surg Pathol 8:709–718

    Article  PubMed  CAS  Google Scholar 

  68. Young RH, Welch WR, Dickersin GR, Scully RE (1982) Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and 4 with adenoma malignum of the cervix. Cancer 50:1384–1402

    Article  PubMed  CAS  Google Scholar 

  69. Aguirre P, Scully RE, Delellis RA (1986) Ovarian heterologous Sertoli-Leydig cell tumors with gastrointestinal-type epithelium. An immunohistochemical analysis. Arch Pathol Lab Med 110:528–533

    PubMed  CAS  Google Scholar 

  70. Young RH, Prat J, Scully RE (1982) Ovarian Sertoli-Leydig cell tumors with heterologous elements. (i) Gastrointestinal epithelium and carcinoid: a clinicopathologic analysis of thirty-six cases. Cancer 50:2448–2456

    Article  PubMed  CAS  Google Scholar 

  71. Prat J, Young RH, Scully RE (1982) Ovarian Sertoli-Leydig cell tumors with heterologous elements. (ii) Cartilage and skeletal muscle: a clinicopathologic analysis of twelve cases. Cancer 50:2465–2475

    Article  PubMed  CAS  Google Scholar 

  72. Young RH, Scully RE (1983) Ovarian Sertoli-Leydig cell tumors with a retiform pattern: a problem in histopathologic diagnosis. A report of 25 cases. Am J Surg Pathol 77:755–771

    Google Scholar 

  73. Kim SH, Kim WH, Park KJ, Lee JK, Kim JS (1996) CT and MR findings of Krukenberg tumors: comparison with primary ovarian tumors. J Comput Assist Tomogr 20:393–398

    Article  PubMed  CAS  Google Scholar 

  74. Scully RE, Young RH, Clement PB (1998) Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament, 3rd edn. Armed Force Institute of Pathology, Washington, DC, pp 189–202

    Google Scholar 

  75. McGowan L, Young RH, Scully RE (1980) Peutz-Jeghers syndrome with “adenoma malignum” of the cervix. A report of two cases. Gynecol Oncol 10:125–133

    Article  PubMed  CAS  Google Scholar 

  76. Srivatsa PJ, Keeney GL, Podratz KC (1994) Disseminated cervical adenoma malignum and bilateral ovarian sex cord tumors with annular tubules associated with Peutz-Jeghers syndrome. Gynecol Oncol 53:256–264

    Article  PubMed  CAS  Google Scholar 

  77. Cserepes E, Szücs N, Patkos P et al (2002) Ovarian steroid cell tumor and a contralateral ovarian thecoma in a postmenopausal woman with severe hyperandrogenism. Gynecol Endocrinol 16:213–216

    PubMed  CAS  Google Scholar 

  78. Wang PH, Chao HT, Lee RC et al (1998) Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis—a case report. Eur J Radiol 26:269

    Article  PubMed  CAS  Google Scholar 

  79. Anderson MC, Rees DA (1975) Gynandroblastoma of the ovary. Br J Obstet Gynaecol 82:68–73

    Article  PubMed  CAS  Google Scholar 

  80. Chalvardjian A, Derzko C (1982) Gynandroblastoma: its ultrastructure. Cancer 50:710–721

    Article  PubMed  CAS  Google Scholar 

  81. Neubecker RD, Breen JL (1962) Gynandroblastoma. A report of five cases with a discussion of the histogenesis and classification of ovarian tumors. Am J Clin Pathol 38:60–69

    PubMed  CAS  Google Scholar 

  82. Scully RE, Young RH, Clement PB (1998) Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament, 3rd edn. Armed Force Institute of Pathology, Washington, DC, pp 203–226

    Google Scholar 

  83. Deval B, Raffi A, Darai E, Hugol D, Buy JN (2003) Slerosing stromal tumor of the ovary. Ultasound Obstet Gynecol 22:531–534

    Article  CAS  Google Scholar 

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  1. Service Radiologie, Hopital Hotel-Dieu, Paris, France

    Jean Noel Buy

  2. Department of Radiology, Hotel Dieu de France, Beirut, Lebanon

    Michel Ghossain

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Buy, J.N., Ghossain, M. (2013). Sex Cord-Stromal Tumors . In: Gynecological Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31012-6_11

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