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Obsessive–Compulsive Disorders in Animals

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Deep Brain Stimulation

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Abstract

An increasing body of evidence suggests deep brain stimulation (DBS) is a therapeutic alternative in the treatment of otherwise therapy-resistant obsessive–compulsive disorders (OCD). An inconsistency in the demonstration of beneficial effects, however, indicates that the optimal DBS parameters and brain sites for the treatment of OCD have not been found yet. This chapter summarizes animal experimental studies using DBS as an investigative tool to systematically map brain regions at which DBS affects symptoms specific to OCD and to draw conclusions on the (patho-)physiological activity of the brain areas investigated in the course of symptom manifestation and reduction. Furthermore, the chapter discusses the translational validity of such animal experimental approaches as well as their contribution to further promote the establishment of DBS in the treatment of patients with otherwise therapy-resistant psychiatric disorders, such as OCD.

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Authors and Affiliations

  1. Section Experimental Psychiatry, Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307, Dresden, Germany

    Christine Winter

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  1. Christine Winter
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Correspondence to Christine Winter .

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Editors and Affiliations

  1. , Department of Psychiatry, Academic Medical Center, University of A, PO Box 75867, Amsterdam, 1070 AW, Netherlands

    Damiaan Denys

  2. , Neuromodulation and Behaviour, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105 BA, Netherlands

    Matthijs Feenstra

  3. , Department of Neurosurger, Academic Medical Center, University of A, Meibergdreef 9, Amsterdam, 1070 AW, Netherlands

    Rick Schuurman

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© 2012 Springer-Verlag Berlin Heidelberg

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Winter, C. (2012). Obsessive–Compulsive Disorders in Animals. In: Denys, D., Feenstra, M., Schuurman, R. (eds) Deep Brain Stimulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30991-5_7

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