Neural Circuits Affected by Deep Brain Stimulation for the Treatment of Psychiatric Disorders

  • Suzanne N. HaberEmail author
  • Benjamin D. Greenberg


The neural network that underlies the pathophysiology of several diseases including obsessive–compulsive disorder (OCD) and major depression (MD) centers on the prefrontal–basal ganglia system. The structures most closely associated with these diseases are the anterior cingulate cortex, the orbitofrontal cortex, the ventral striatum, and parts of the thalamus. The most successful deep brain stimulation (DBS) targets for the treatment of OCD and MD are centered in white matter tracts and/or gray matter, chosen for their central location to capture specific prefrontal connections of the subgenual anterior cingulate and orbital cortex. As more knowledge is obtained concerning the details of these connections, more precise targets may be possible. This chapter reviews the connectivities likely to be involved at different DBS sites on the basis of non-human-primate circuitry studies of the ventral anterior cingulate gyrus and orbital cortex.


Deep Brain Stimulation Anterior Cingulate Cortex White Matter Tract Internal Capsule Ventral Striatum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Anterior commissure


Anterior cingulate cortex


Dorsal anterior cingulate cortex


Deep brain stimulation


Major depression


Obsessive–compulsive disorder


Orbitofrontal cortex


Prefrontal cortex


Subgenual cingulate gyrus white matter


Ventral anterior internal capsule


Ventromedial prefrontal cortex


Ventral prefrontal cortex


Ventral striatum



This work was supported by NIH grants MH086400 and MH73111.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Pharmacology and Physiology, School of Medicine and DentistryUniversity of RochesterRochesterUSA
  2. 2.Department of Psychiatry and Human Behavior, Alpert Medical School, Butler HospitalBrown UniversityProvidenceUSA

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