Surgical Treatments for Drug Addictions in Humans
Drug addiction is a difficult problem worldwide, causing severe social, medical, and criminal problems. Current therapies such as drug substitution are not satisfactory, especially in treating craving and psychological dependence. In recent years, surgical treatment for drug addiction has attracted worldwide attention, as the development of new techniques such as deep brain stimulation provided more possibilities to pursue new therapeutic strategies for this notorious disease. Stereotactic nucleus accumbens lesioning and deep brain stimulation are presently the main surgical procedures for treatment of drug addiction. These procedures are safe, minimally invasive, and effective with few side effects.
KeywordsDrug addiction Ablative surgery Deep brain stimulation Neuromodulation Substance abuse Stereotactic neurosurgery Nucleus accumbens Psychosurgery
- Halpern CH, Torres N, Hurtig HI, Wolf JA, Stephen J, Oh MY, Williams NN, Dichter MA, Jaggi JL, Caplan AL, Kampman KM, Wadden TA, Whiting DM, Baltuch GH (2011) Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. Acta Neurochir 153:2293–2306Google Scholar
- Heinze HJ, Heldmann M, Voges J, Hinrichs H, Marco-Pallares J, Hopf JM, Muller UJ, Galazky I, Sturm V, Bogerts B, Munte TF (2009) Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects. Front Hum Neurosci 3:22PubMedCrossRefGoogle Scholar
- Holtzheimer PE, Mayberg HS (2011) Deep brain stimulation for psychiatric disorders. Ann Rev Neurosci 34:289–307Google Scholar
- Kuhn J, Moller M, Muller U, Bogerts B, Mann K, Grundler TO (2011) Deep brain stimulation for the treatment of addiction. Addiction 106:1536–1537(1537–1538)Google Scholar
- Mantione M, van de Brink W, Schuurman PR, Denys D (2010) Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report. Neurosurgery 66:218–218Google Scholar