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Deep Brain Stimulation in Animal Models of Depression

  • Brian W. Scott
  • José N. Nobrega
  • Clement Hamani
Chapter

Abstract

Deep brain stimulation (DBS) involves the delivery of electrical current to a specific brain site through chronically implanted electrodes. The procedure has shown promising results in investigational clinical trials to treat depression. Studies in animal models have recently been conducted to explore potential mechanisms and the substrates involved in the antidepressant-like effects of DBS. In this chapter, we review such studies and highlight some of the basic concepts for conducting preclinical research using DBS.

Keywords

Deep brain stimulation Depression Animal models Preclinical studies 

Notes

Acknowledgments and Conflicts of Interest

Experimental work conducted by the authors has been supported in part by funds from the Brain & Behavior Research Foundation (NARSAD), the Ontario Mental Health Foundation, and the Canadian Institutes for Health Research. C.H. is a consultant to St. Jude Medical.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Brian W. Scott
    • 1
  • José N. Nobrega
    • 1
  • Clement Hamani
    • 1
    • 2
  1. 1.Neuroimaging Research SectionCentre for Addiction and Mental HealthTorontoCanada
  2. 2.Division of NeurosurgeryToronto Western HospitalTorontoCanada

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