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How Do Production Systems in Biological Cells Maintain Their Function in Changing Environments?

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Book cover Robust Manufacturing Control

Part of the book series: Lecture Notes in Production Engineering ((LNPE))

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Abstract

Metabolism is a fascinating natural production and distribution process. Metabolic systems can be represented as a layered network, where the input layer consists of all the nutrients in the environment (raw materials entering the production process in the cell), subsequently to be processed by a complex network of biochemical reactions (middle layer) and leading to a well-defined output pattern, optimizing, e.g., cell growth. Mathematical frameworks exploiting this layered-network representation of metabolism allow the prediction of metabolic fluxes (the cell’s ’material flow’) under diverse conditions. In combination with suitable minimal models it is possible to identify fundamental design principles and understand the efficiency and robustness of metabolic systems. Here, we summarize some design principles of metabolic systems from the perspective of production logistics and explore, how these principles can serve as templates for the design of robust manufacturing systems.

This contribution was previously published in Logistics Research (2012) pp. 79–87. DOI: 10.1007/s12159 012-0090-0.

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Acknowledgments

MEB is supported by a Deutsche Forschungsgemeinschaft grant to MTH (grant HU-937/6). We are indebted to Nikolaus Sonnenschein (San Diego, USA) for providing his expertise on flux-balance analysis. We gratefully acknowledge discussions and close collaboration with Katja Windt (Bremen, Germany) on the parallels of metabolism and manufacturing.

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Authors and Affiliations

  1. School of Engineering and Science, Jacobs University, Campus Ring 1, D-28759, Bremen, Germany

    Moritz Emanuel Beber & Marc-Thorsten Hütt

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  1. Moritz Emanuel Beber
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  2. Marc-Thorsten Hütt
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Correspondence to Moritz Emanuel Beber .

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  1. , Global Production Logistics - Internatio, Jacobs University Bremen, Campus Ring 1, Bremen, 28759, Germany

    Katja Windt

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Beber, M.E., Hütt, MT. (2013). How Do Production Systems in Biological Cells Maintain Their Function in Changing Environments?. In: Windt, K. (eds) Robust Manufacturing Control. Lecture Notes in Production Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30749-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-30749-2_1

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