Abstract
The phenomenon of intraovarian oocyte release (IOR) into the cortical stroma has been widely neglected and is described here in the different species studied. Preantral IOR and antral IOR occur in immature and in cyclic ovaries. Herniated granulosa cells show cytoplasmic shedding similar to interstitial gland cells. The IOR oocyte resembles a mature oocyte and can survive in a regressing CL as herniated granulosa cells also do. Many IORs from preovulatory follicles develop in superovulated ovaries. The preovulatory IORs are associated with CL formation, severe damage to the cortical stroma, and fibrin thrombi. They enclose granulosa cells and the cumulus–oocyte complex. The occurrence of IOR is increased or inhibited by pharmacological treatment with melatonin or arginine vasotocin, respectively. Repeatedly conducted superovulations inhibit IORs because of an insufficient microvascular bed. The occurrence of preantral IOR and antral IOR is the ultimate proof of a gonadotropin-independent follicle rupture. Intraovarian factors are finally responsible and probably belong to the network of innate immunity. The network activates the rupture cascade in many preovulatory follicles of superovulated ovaries. The subsequent severe tissue damage does not leave permanent harm in a once superovulated ovary.
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Spanel-Borowski, K. (2012). Intraovarian Oocyte Release (IOR) with Severe Tissue Damage. In: Atlas of the Mammalian Ovary. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30535-1_7
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DOI: https://doi.org/10.1007/978-3-642-30535-1_7
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