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Outer Membrane Vesicles: Physiological Medical Applications

  • S. N. ChatterjeeEmail author
  • Keya Chaudhuri
Chapter
Part of the SpringerBriefs in Microbiology book series (BRIEFSMICROBIOL)

Abstract

Outer membrane vesicles (OMVs) produced by Gram-negative bacteria exhibit enormous functional diversity depending on the bacterial species and environmental niche: these have enabled various physiological roles for these vesicles to play and at the same time OMVs have found important medical applications. The interaction of OMVs with the host can lead to varied innate immune responses such as direct interaction with immune cells, triggering of cell-mediated immunity, or activation of proinflammatory response leading to cytotoxicity. OMVs were found to carry antigenically active virulence factors and the potential of OMVs for nonreplicating vaccines has been explored in several Gram-negative organisms in animal models. OMVs are being licensed and used for vaccination in combating Neisseria meningitidis serogroup B infections.

Keywords

Innate immune response B cell Complement system Cell-mediated immunity Proinflammatory response Immunogen Vaccine Detergent-treated OMVs Native OMVs Combination vaccines Recombinant OMV vaccines  Reverse vaccinology Adjuvant 

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© The Author(s) 2012

Authors and Affiliations

  1. 1.BiophysicsFormerly of Saha Institute of Nuclear PhysicsKolkataIndia

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