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Cell Lineages, Growth and Repair of the Mouse Heart

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Mouse Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 55))

Abstract

The formation of the heart involves diversification of lineages which differentiate into distinct cardiac cell types or contribute to different regions such as the four cardiac chambers. The heart is the first organ to form in the embryo. However, in parallel with the growth of the organism, before or after birth, the heart has to adapt its size to maintain pumping efficiency. The adult heart has only a mild regeneration potential; thus, strategies to repair the heart after injury are based on the mobilisation of resident cardiac stem cells or the transplantation of external sources of stem cells. We discuss current knowledge on these aspects and raise questions for future research.

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Acknowledgements

We thank M. Buckingham and D. Montarras for insightful discussions. SMM is an INSERM research scientist and FL is supported by the CardioCell (FP7 - HEALTH-2007-2.4.2-5) EU project to M. Buckingham.

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  1. Department of Developmental Biology, Institut Pasteur, Unit of Molecular Genetics of Development, 75015, Paris, France

    Fabienne Lescroart & Sigolène M. Meilhac

  2. CNRS, URA2578, 75015, Paris, France

    Fabienne Lescroart & Sigolène M. Meilhac

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  1. Fabienne Lescroart
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  2. Sigolène M. Meilhac
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Correspondence to Sigolène M. Meilhac .

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  1. CNRS UMR 6061, Fac. Médecine, Université de Rennes 1, Rennes CX, 35043, France

    Jacek Z. Kubiak

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Lescroart, F., Meilhac, S.M. (2012). Cell Lineages, Growth and Repair of the Mouse Heart. In: Kubiak, J. (eds) Mouse Development. Results and Problems in Cell Differentiation, vol 55. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30406-4_15

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