Skip to main content
SpringerLink
Log in

Beurteilung und Therapie der Lutealphase

  • Chapter
Book cover Reproduktionsmedizin

  • 4284 Accesses

Zusammenfassung

Die Lutealphase beginnt nach der Ovulation, die durch den mittzyklischen Anstieg von luteinisierendem Hormon (LH) ausgelöst wird. Hierbei entsteht mit der Freisetzung der Eizelle aus dem dominanten Follikel das Corpus luteum, das neben Östrogenen sowie anderen Hormonen und Wachstumsfaktoren Progesteron als das Schlüsselhormon der zweiten Zyklushälfte sezerniert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Altmae S et al. (2010) Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 16 (3): 178–87

    Article  PubMed  CAS  Google Scholar 

  • Andersen AN et al. (2002) Progesterone supplementation during early gestations after IVF or ICSI has no effect on the delivery rates: a randomized controlled trial. Hum Reprod 17 (2): 357–361

    Article  CAS  Google Scholar 

  • Beckers NG et al. (2003) Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropinreleasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab 88 (9): 4186–4192

    Article  PubMed  CAS  Google Scholar 

  • Bishop CV, Hennebold JD, Stouffer RL (2009) The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum. Mol Hum Reprod 15 (3): 181–193

    Article  PubMed  CAS  Google Scholar 

  • Branch DW, Gibson M, Silver RM (2010) Clinical practice. Recurrent miscarriage. N Engl J Med 363 (18): 1740–1747

    CAS  Google Scholar 

  • Brown JB (2011) Types of ovarian activity in women and their significance: the continuum (a reinterpretation of early findings). Hum Reprod Update 17 (2): 141–58

    Article  PubMed  CAS  Google Scholar 

  • Carmichael SL et al. (2005) Maternal progestin intake and risk of hypospadias. Arch Pediatr Adolesc Med 159 (10): 957–962

    Article  PubMed  Google Scholar 

  • Coetsier T, Dhont M (1996) Complete and partial luteinized unruptured follicle syndrome after ovarian stimulation with clomiphene citrate/human menopausal gonadotrophin/human chorionic gonadotrophin. Hum Reprod 11 (3): 583–587

    Article  PubMed  CAS  Google Scholar 

  • Coutifaris C et al. (2004) Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril 82 (5): 1264–1272

    Article  PubMed  Google Scholar 

  • Crosignani PG, Rubin BL (2000) Optimal use of infertility diagnostic tests and treatments. The ESHRE Capri Workshop Group. Hum Reprod 15 (3): 723–732

    Article  PubMed  CAS  Google Scholar 

  • Csapo AI, Pulkkinen M (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy. Luteectomy evidence. Obstet Gynecol Surv 33 (2): 69–81

    Article  PubMed  CAS  Google Scholar 

  • Davis OK et al. (1989) The incidence of luteal phase defect in normal, fertile women, determined by serial endometrial biopsies. Fertil Steril 51 (4): 582–586

    PubMed  CAS  Google Scholar 

  • Daya S, Gunby J (2004) Luteal phase support in assisted reproduction cycles. Cochrane Database Syst Rev 3: CD004830

    Google Scholar 

  • Souza MJ et al. (2010) High prevalence of subtle and severe menstrual disturbances in exercising women: confirmation using daily hormone measures. Hum Reprod 25 (2): 491–503

    Article  PubMed  Google Scholar 

  • Devaseelan P, Fogarty PP, Regan L (2010) Human chorionic gonadotrophin for threatened miscarriage. Cochrane Database Syst Rev 5: CD007422

    Google Scholar 

  • Devoto L et al. (2002) Control of human luteal steroidogenesis. Mol Cell Endocrinol 186 (2): 137–141

    Article  PubMed  CAS  Google Scholar 

  • Devoto L et al. (2009) The human corpus luteum: life cycle and function in natural cycles. Fertil Steril 92 (3): 1067–79

    Article  PubMed  CAS  Google Scholar 

  • Edwards RG, Steptoe PC, Purdy JM (1908) Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol 87 (9): 737–756

    Google Scholar 

  • Ellinwood WE, Norman RL, Spies HG (1984) Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol Reprod 31 (4): 714–722

    Article  PubMed  CAS  Google Scholar 

  • Fan HY et al. (2009) MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science 324 (5929): 938–941

    Article  PubMed  CAS  Google Scholar 

  • Fatemi HM et al. (2007) An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update 13 (6): 581–590

    Article  PubMed  CAS  Google Scholar 

  • Fauser BC, Devroey P (2003) Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab 14 (5): 236–242

    Article  PubMed  CAS  Google Scholar 

  • Haas DM, Ramsey PS (2008) Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2: CD003511

    Google Scholar 

  • Jarvela IY, Ruokonen A, Tekay A (2008) Effect of rising hCG levels on the human corpus luteum during early pregnancy. Hum Reprod 23 (12): 2775–2781

    Article  PubMed  Google Scholar 

  • Jones GE (1949) Some newer aspects of the management of infertility. J Am Med Assoc 141 (16): 1123–1129, illust

    Article  PubMed  CAS  Google Scholar 

  • Jordan J et al. (1994) Luteal phase defect: the sensitivity and specificity of diagnostic methods in common clinical use. Fertil Steril 62 (1): 54–62

    PubMed  CAS  Google Scholar 

  • Kolibianakis EM et al. (2008) Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. Hum Reprod 23 (6): 1346–1354

    Article  PubMed  CAS  Google Scholar 

  • Krieg J, Hornung D, Kiesel L (2012) Regulation der Fortpflanzungsfunktion. In: Kaufmann M, Costa C, Scharl A (Hrsg) Die Gynäkologie, Kap 8. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Kyrou D et al. (2011) Does cessation of progesterone supplementation during early pregnancy in patients treated with recFSH/GnRH antagonist affect ongoing pregnancy rates? A randomized controlled trial. Hum Reprod 26 (5): 1020–1024

    Article  PubMed  CAS  Google Scholar 

  • Licciardi FL et al. (1999) Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study. Fertil Steril 71 (4): 614–618

    Article  PubMed  CAS  Google Scholar 

  • Ludwig M (2010) Gynäkologische Endokrinologie. Optimist-Fachbuchverlag, Hamburg

    Google Scholar 

  • Ludwig M, Sonntag B (2010) LUF-Syndrom: häufig, selten oder nicht existent? Gynäkol Endokrinol 8 (2): 112–116

    Article  Google Scholar 

  • Malcolm CE, Cumming DC (2003) Does anovulation exist in eumenorrheic women? Obstet Gynecol 102 (2): 317–318

    Article  PubMed  Google Scholar 

  • Murray MJ et al. (2004) A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 81 (5): 1333–1343

    Article  PubMed  Google Scholar 

  • Niswender GD et al. (2000) Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev 80 (1): 1–29

    PubMed  CAS  Google Scholar 

  • Noyes RW,Hertig AT, Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1: 3–9

    Google Scholar 

  • Pritts EA, Atwood AK (2002) Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod 17 (9): 2287–2299

    Article  PubMed  CAS  Google Scholar 

  • Proctor A et al. (2006) Effect of progesterone supplementation in early pregnancy on the pregnancy outcome after in vitro fertilization. Fertil Steril 85 (5): 1550–1552

    Article  PubMed  CAS  Google Scholar 

  • Qublan H et al. (2006) Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination. Hum Reprod 21 (8): 2110–2113

    Article  PubMed  CAS  Google Scholar 

  • Soules MR et al. (1989) Luteal phase deficiency: abnormal gonadotropin and progesterone secretion patterns. J Clin Endocrinol Metab 69 (4): 813–820

    Article  PubMed  CAS  Google Scholar 

  • Szekeres-Bartho J, Balasch J (2008) Progestagen therapy for recurrent miscarriage. Hum Reprod Update 14 (1): 27–35

    Article  PubMed  Google Scholar 

  • Toth B et al. (2010) Lutealphaseninsuffizienz. Schwächelt der Gelbkörper wirklich? Gynäkol Endokrinol 2010. 8: 105–111

    Google Scholar 

  • Usadi RS et al. (2008) Endometrial development and function in experimentally induced luteal phase deficiency. J Clin Endocrinol Metab 93 (10): 4058–4064

    Article  PubMed  CAS  Google Scholar 

  • Wilcox AJ, Baird DD, Weinberg CR (1999) Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 340 (23): 1796–9

    Article  PubMed  CAS  Google Scholar 

  • Yanushpolsky E et al. (2010) Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles: a prospective randomized study. Fertil Steril 94 (7): 2596–2599

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. amedes, Zentrum für Endokrinologie, Kinderwunsch und Pränatale Medizin im Barkhof, Mönckebergstraße 10, 20095, Hamburg

    Priv.-Doz. Dr. med. B. Sonntag

Authors
  1. Priv.-Doz. Dr. med. B. Sonntag
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinikum Schleswig-Holstein, Schleswig-Holstein, Campus Lübeck

    Klaus Diedrich  & Georg Griesinger  & 

  2. amedes, Zentrum für Endokrinologie, Kinderwunsch und Pränatale Medizin im Barkhof, Hamburg

    Michael Ludwig

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sonntag, B. (2013). Beurteilung und Therapie der Lutealphase. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30181-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-30181-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-30180-3

  • Online ISBN: 978-3-642-30181-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation